Stimulation of innate immune cells by light-activated TLR7/8 agonists.

PubWeight™: 0.89‹?›

🔗 View Article (PMC 4132957)

Published in J Am Chem Soc on July 28, 2014

Authors

Keun Ah Ryu1, Lalisa Stutts, Janine K Tom, Rock J Mancini, Aaron P Esser-Kahn

Author Affiliations

1: Department of Chemistry, University of California , Irvine, California 92697, United States.

Articles cited by this

Innate immune recognition. Annu Rev Immunol (2001) 26.65

Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15

Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol (2001) 18.80

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol (2002) 13.10

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A (2000) 9.67

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell (2006) 6.01

Innate immune sensing and its roots: the story of endotoxin. Nat Rev Immunol (2003) 5.46

Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic Res Commun (1992) 4.45

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol (2002) 4.21

Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling. Science (2004) 3.08

Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A (2003) 2.91

Antibody-dependent killing of erythrocyte and tumor targets by macrophage-related cell lines: enhancement by PPD and LPS. J Immunol (1977) 2.67

Illuminating the chemistry of life: design, synthesis, and applications of "caged" and related photoresponsive compounds. ACS Chem Biol (2009) 2.67

Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands. Science (2013) 1.47

Photolysis of caged calcium in femtoliter volumes using two-photon excitation. Biophys J (1999) 1.42

Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7. Bioorg Med Chem Lett (2010) 1.08

Inhibition of murine tumor growth by an interferon-inducing imidazoquinolinamine. Cancer Res (1992) 1.04

Potent adjuvanticity of a pure TLR7-agonistic imidazoquinoline dendrimer. PLoS One (2012) 1.04

The imidazoquinolines, imiquimod and R-848, induce functional, but not phenotypic, maturation of human epidermal Langerhans' cells. Clin Immunol (2000) 1.02

Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines. J Med Chem (2012) 1.02

Optically selective two-photon uncaging of glutamate at 900 nm. J Am Chem Soc (2013) 1.02

Preliminary evaluation of a 3H imidazoquinoline library as dual TLR7/TLR8 antagonists. Bioorg Med Chem (2011) 0.93

Discovering NF-kappaB. Cold Spring Harb Perspect Biol (2009) 0.89

5-substituted 2-amino-6-phenyl-4(3H)-pyrimidinones. Antiviral- and interferon-inducing agents. J Med Chem (1980) 0.88

Intramolecular sensitization of photocleavage of the photolabile 2-(2-nitrophenyl)propoxycarbonyl (NPPOC) protecting group: photoproducts and photokinetics of the release of nucleosides. Chemistry (2008) 0.85

Structure-activity relationships in Toll-like receptor 7 agonistic 1H-imidazo[4,5-c]pyridines. Org Biomol Chem (2013) 0.85

Grand challenge commentary: Synthetic immunology to engineer human immunity. Nat Chem Biol (2010) 0.84

Pattern recognition theory and the launch of modern innate immunity. J Immunol (2013) 0.82

Antitumor activity of pyrimidinones, a class of small-molecule biological response modifiers. J Biol Response Mod (1987) 0.81

Articles by these authors

N-terminal protein modification through a biomimetic transamination reaction. Angew Chem Int Ed Engl (2006) 1.77

Identification of highly reactive sequences for PLP-mediated bioconjugation using a combinatorial peptide library. J Am Chem Soc (2010) 1.07

Modification of aniline containing proteins using an oxidative coupling strategy. J Am Chem Soc (2006) 1.04

Chemical treatment of poly(lactic acid) fibers to enhance the rate of thermal depolymerization. ACS Appl Mater Interfaces (2011) 0.92

A three-dimensional microvascular gas exchange unit for carbon dioxide capture. Lab Chip (2012) 0.87

Directing the immune system with chemical compounds. ACS Chem Biol (2014) 0.83

Covalently coupled immunostimulant heterodimers. Angew Chem Int Ed Engl (2013) 0.83

Controlling the origins of inflammation with a photoactive lipopeptide immunopotentiator. Angew Chem Int Ed Engl (2015) 0.81

Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation. Chem Commun (Camb) (2013) 0.78

Process of making three-dimensional microstructures using vaporization of a sacrificial component. J Vis Exp (2013) 0.75

Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as Vaccine Adjuvant. Bioconjug Chem (2017) 0.75

Three-dimensional conformal coatings through the entrapment of polymer membrane precursors. ACS Appl Mater Interfaces (2014) 0.75

Correction to "Programmable Microcapsules from Self-Immolative Polymers. J Am Chem Soc (2016) 0.75

Photothermal Nanoparticle Initiation Enables Radical Polymerization and Yields Unique, Uniform Microfibers with Broad Spectrum Light. ACS Appl Mater Interfaces (2017) 0.75

A microvascular system for chemical reactions using surface waste heat. Angew Chem Int Ed Engl (2013) 0.75