Published in J Med Chem on August 05, 2014
NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke. Stroke (2007) 2.13
Mechanism of lipid-body formation in prokaryotes: how bacteria fatten up. Mol Microbiol (2005) 1.83
Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain. Eur J Pain (2010) 1.77
(-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): a novel mu-opioid receptor agonist/norepinephrine reuptake inhibitor with broad-spectrum analgesic properties. J Pharmacol Exp Ther (2007) 1.72
Broad analgesic profile of buprenorphine in rodent models of acute and chronic pain. Eur J Pharmacol (2004) 1.48
Urodynamic effects of the K+ channel (KCNQ) opener retigabine in freely moving, conscious rats. J Urol (2004) 1.41
Bioelectrical impedance assay to monitor changes in cell shape during apoptosis. Biosens Bioelectron (2004) 1.24
Murine brain capillary endothelial cells exhibit improved barrier properties under the influence of hydrocortisone. Brain Res (2005) 1.17
Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood-brain barrier. Brain Res (2003) 1.17
Nanoparticle interaction with model lung surfactant monolayers. J R Soc Interface (2009) 1.13
Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nat Med (2013) 1.10
The effect of compatible solute ectoines on the structural organization of lipid monolayer and bilayer membranes. Biophys Chem (2010) 1.09
Control of the blood-brain barrier by glucocorticoids and the cells of the neurovascular unit. Ann N Y Acad Sci (2009) 1.07
The impact of glia-derived extracellular matrices on the barrier function of cerebral endothelial cells: an in vitro study. Exp Cell Res (2007) 1.07
Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma. Nat Commun (2013) 1.06
The impact of pericytes on the blood-brain barrier integrity depends critically on the pericyte differentiation stage. Int J Biochem Cell Biol (2011) 1.06
Polar bacterial invasion and translocation of Streptococcus suis across the blood-cerebrospinal fluid barrier in vitro. Cell Microbiol (2008) 1.06
2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: structure activity relationships of the 2-oxy pyridine C-region. Eur J Med Chem (2013) 1.05
Mechanistic and functional differentiation of tapentadol and tramadol. Expert Opin Pharmacother (2012) 1.04
Automated multi-well device to measure transepithelial electrical resistances under physiological conditions. Biotechniques (2004) 1.03
Tapentadol hydrochloride: a next-generation, centrally acting analgesic with two mechanisms of action in a single molecule. Drugs Today (Barc) (2009) 1.03
Permeabilization in a cerebral endothelial barrier model by pertussis toxin involves the PKC effector pathway and is abolished by elevated levels of cAMP. J Cell Sci (2003) 1.03
Metalloproteinase mediated occludin cleavage in the cerebral microcapillary endothelium under pathological conditions. Brain Res (2010) 1.02
Expression and adhesive properties of basement membrane proteins in cerebral capillary endothelial cell cultures. Cell Tissue Res (2002) 1.01
Impedance-based cell monitoring: barrier properties and beyond. Fluids Barriers CNS (2013) 1.00
Regulation of major efflux transporters under inflammatory conditions at the blood-brain barrier in vitro. J Neurochem (2009) 0.99
Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice. Mol Cell Neurosci (2007) 0.99
Cebranopadol: a novel potent analgesic nociceptin/orphanin FQ peptide and opioid receptor agonist. J Pharmacol Exp Ther (2014) 0.99
Interaction of mu-opioid receptor agonists and antagonists with the analgesic effect of buprenorphine in mice. Eur J Pain (2005) 0.98
Localization of the Na+-D-glucose cotransporter SGLT1 in the blood-brain barrier. Histochem Cell Biol (2004) 0.98
Serum-derived factors weaken the barrier properties of cultured porcine brain capillary endothelial cells in vitro. Brain Res (2003) 0.98
Lipid segregation and membrane budding induced by the peripheral membrane binding protein annexin A2. J Biol Chem (2013) 0.97
Two-component in situ forming supramolecular hydrogels as advanced biomaterials in vitreous body surgery. Macromol Biosci (2012) 0.97
Transport of Poly(n-butylcyano-acrylate) nanoparticles across the blood-brain barrier in vitro and their influence on barrier integrity. Biochem Biophys Res Commun (2011) 0.96
Fe-catalyzed oxidative coupling of heteroarenes and methylamines. Chem Asian J (2009) 0.96
Actions of tramadol on micturition in awake, freely moving rats. Br J Pharmacol (2003) 0.96
Strain-dependent disruption of blood-cerebrospinal fluid barrier by Streptoccocus suis in vitro. FEMS Immunol Med Microbiol (2005) 0.96
In vitro studies indicate that miquelianin (quercetin 3-O-beta-D-glucuronopyranoside) is able to reach the CNS from the small intestine. Planta Med (2003) 0.94
Neutrophils cross the BBB primarily on transcellular pathways: an in vitro study. Brain Res (2010) 0.94
MMPs contribute to TNF-alpha-induced alteration of the blood-cerebrospinal fluid barrier in vitro. Am J Physiol Cell Physiol (2007) 0.94
Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study. Nanoscale (2010) 0.94
Receptor-mediated delivery of magnetic nanoparticles across the blood-brain barrier. ACS Nano (2012) 0.93
Interaction of polyelectrolytes and their composites with living cells. Nano Lett (2005) 0.93
Sila-haloperidol, a silicon analogue of the dopamine (D2) receptor antagonist haloperidol: synthesis, pharmacological properties, and metabolic fate. ChemMedChem (2008) 0.93
Characterization of the synthetic compatible solute homoectoine as a potent PCR enhancer. Biochem Biophys Res Commun (2004) 0.92
Monolayer-multilayer transitions in a lung surfactant model: IR reflection-absorption spectroscopy and atomic force microscopy. Eur Biophys J (2005) 0.92
Multilayer structures in lipid monolayer films containing surfactant protein C: effects of cholesterol and POPE. Biophys J (2005) 0.92
A new multidrug resistance protein at the blood-brain barrier. Biochem Biophys Res Commun (2002) 0.91
Transcellular migration of neutrophil granulocytes through the blood-cerebrospinal fluid barrier after infection with Streptococcus suis. J Neuroinflammation (2011) 0.91
Kinetics of phospholipid insertion into monolayers containing the lung surfactant proteins SP-B or SP-C. Eur Biophys J (2002) 0.91
Comparison of five peptide vectors for improved brain delivery of the lysosomal enzyme arylsulfatase A. J Neurosci (2014) 0.90
Features of idebenone and related short-chain quinones that rescue ATP levels under conditions of impaired mitochondrial complex I. PLoS One (2012) 0.90
Pericyte-endothelial cell interaction increases MMP-9 secretion at the blood-brain barrier in vitro. Brain Res (2007) 0.90
Dexamethasone prevents alteration of tight junction-associated proteins and barrier function in porcine choroid plexus epithelial cells after infection with Streptococcus suis in vitro. Brain Res (2008) 0.90
Cell death, caspase activation, and HMGB1 release of porcine choroid plexus epithelial cells during Streptococcus suis infection in vitro. Brain Res (2006) 0.89
Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem (2010) 0.88
Molecular imaging of σ receptors: synthesis and evaluation of the potent σ1 selective radioligand [18F]fluspidine. Eur J Nucl Med Mol Imaging (2010) 0.88
The antiallodynic effect of NMDA antagonists in neuropathic pain outlasts the duration of the in vivo NMDA antagonism. Neuropharmacology (2006) 0.88
High-resolution investigation of nanoparticle interaction with a model pulmonary surfactant monolayer. ACS Nano (2012) 0.88
Biostable aptamers with antagonistic properties to the neuropeptide nociceptin/orphanin FQ. RNA (2004) 0.88
Compatible solutes: ectoine and hydroxyectoine improve functional nanostructures in artificial lung surfactants. Biochim Biophys Acta (2011) 0.87
Reverse Sanger sequencing of RNA by MALDI-TOF mass spectrometry after solid phase purification. Nucleic Acids Res (2004) 0.87
Impact of manganese on and transfer across blood-brain and blood-cerebrospinal fluid barrier in vitro. J Biol Chem (2012) 0.87
Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. Biochemistry (2009) 0.86
Influence of T-2 and HT-2 toxin on the blood-brain barrier in vitro: new experimental hints for neurotoxic effects. PLoS One (2013) 0.86
Surface view of the lateral organization of lipids and proteins in lung surfactant model systems-a ToF-SIMS approach. Biochim Biophys Acta (2009) 0.86
Transport of arylsulfatase A across the blood-brain barrier in vitro. J Biol Chem (2011) 0.86
Regulation of the blood-brain barrier integrity by pericytes via matrix metalloproteinases mediated activation of vascular endothelial growth factor in vitro. Brain Res (2010) 0.86
Properties of compatible solutes in aqueous solution. Biophys Chem (2011) 0.86
Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1. J Med Chem (2002) 0.84
Functional characterisation of the active ascorbic acid transport into cerebrospinal fluid using primary cultured choroid plexus cells. Brain Res (2003) 0.84
Phorbol ester induced short- and long-term permeabilization of the blood-CSF barrier in vitro. Brain Res (2005) 0.84
Platelet-derived growth factor receptor expression and activation in choroid plexus tumors. Am J Pathol (2009) 0.84
The antinociceptive and antihyperalgesic effect of tapentadol is partially retained in OPRM1 (μ-opioid receptor) knockout mice. Neurosci Lett (2011) 0.84
Aromatic C-H bond hydroxylation by P450 peroxygenases: a facile colorimetric assay for monooxygenation activities of enzymes based on Russig's blue formation. J Biol Inorg Chem (2010) 0.83
Metabolism studies of ifenprodil, a potent GluN2B receptor antagonist. J Pharm Biomed Anal (2013) 0.83
Expression of Shiga toxin 2e glycosphingolipid receptors of primary porcine brain endothelial cells and toxin-mediated breakdown of the blood-brain barrier. Glycobiology (2013) 0.83
Quality and functionality of saffron: quality control, species assortment and affinity of extract and isolated saffron compounds to NMDA and sigma1 (sigma-1) receptors. Planta Med (2008) 0.83
Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols. Bioorg Med Chem (2010) 0.83
Permeability of ergot alkaloids across the blood-brain barrier in vitro and influence on the barrier integrity. Mol Nutr Food Res (2011) 0.83