PubRank

M S Neuberger

Author PubWeight™ 128.43‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence. Cell 1985 4.38
2 Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature 1986 4.19
3 Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies. J Exp Med 1987 3.82
4 B cells acquire antigen from target cells after synapse formation. Nature 2001 3.31
5 Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate. Immunity 1998 3.27
6 Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity 1998 3.16
7 Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation. Nature 2001 3.09
8 Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell 1994 3.06
9 Hyperresponsive B cells in CD22-deficient mice. Science 1996 2.86
10 TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity 1998 2.76
11 A hapten-specific chimaeric IgE antibody with human physiological effector function. Nature 1985 2.63
12 Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation. EMBO J 1999 2.58
13 The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region. EMBO J 1989 2.48
14 Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice. Nucleic Acids Res 1997 2.44
15 Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc Natl Acad Sci U S A 1993 2.30
16 Activation of mouse complement by monoclonal mouse antibodies. Eur J Immunol 1981 2.11
17 Somatic hypermutation. Curr Opin Immunol 1995 2.08
18 The B-cell antigen receptor of the five immunoglobulin classes. Nature 1991 1.97
19 Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response. Proc Natl Acad Sci U S A 1998 1.94
20 Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol Today 1993 1.93
21 Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies. J Exp Med 1999 1.83
22 Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes. EMBO J 1991 1.83
23 Regulation of membrane IgM expression in secretory B cells: translational and post-translational events. EMBO J 1987 1.82
24 Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature 1995 1.80
25 Both DNA strands of antibody genes are hypermutation targets. Proc Natl Acad Sci U S A 1998 1.77
26 Recombinant antibodies possessing novel effector functions. Nature 1985 1.76
27 Somatic hypermutation of immunoglobulin genes. Annu Rev Immunol 1996 1.72
28 Codon bias targets mutation. Nature 1995 1.69
29 Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination. Proc Natl Acad Sci U S A 2001 1.69
30 A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus. Nature 1990 1.65
31 The importance of the 3'-enhancer region in immunoglobulin kappa gene expression. Nucleic Acids Res 1990 1.56
32 Disruption of mouse polymerase zeta (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro. Curr Biol 2000 1.54
33 The mouse IgH 3'-enhancer. Eur J Immunol 1991 1.50
34 Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgG autoantibodies. J Exp Med 2000 1.49
35 Switch from hapten-specific immunoglobulin M to immunoglobulin D secretion in a hybrid mouse cell line. Proc Natl Acad Sci U S A 1981 1.48
36 Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers. EMBO J 1997 1.46
37 Expression and targeting of intracellular antibodies in mammalian cells. EMBO J 1990 1.38
38 Purification and properties of Klebsiella aerogenes D-arabitol dehydrogenase. Biochem J 1979 1.38
39 Association of CD22 with the B cell antigen receptor. Eur J Immunol 1993 1.35
40 Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity. J Exp Med 2000 1.34
41 B cells extract and present immobilized antigen: implications for affinity discrimination. EMBO J 2000 1.31
42 The half-life of immunoglobulin mRNA increases during B-cell differentiation: a possible role for targeting to membrane-bound polysomes. Genes Dev 1988 1.31
43 Reciprocal chromosome translocation between c-myc and immunoglobulin gamma 2b genes. Nature 1983 1.31
44 Polymeric immunoglobulin M is secreted by transfectants of non-lymphoid cells in the absence of immunoglobulin J chain. EMBO J 1987 1.30
45 The targeting of somatic hypermutation. Semin Immunol 1996 1.29
46 The immunogenicity of chimeric antibodies. J Exp Med 1989 1.25
47 The sequence of the mu transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface. J Exp Med 1990 1.18
48 The alpha/beta sheath and its cytoplasmic tyrosines are required for signaling by the B-cell antigen receptor but not for capping or for serine/threonine-kinase recruitment. Proc Natl Acad Sci U S A 1994 1.18
49 Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions. Proc Natl Acad Sci U S A 1994 1.16
50 Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D). Int Immunol 1996 1.14
51 Acceleration of intracellular targeting of antigen by the B-cell antigen receptor: importance depends on the nature of the antigen-antibody interaction. EMBO J 1997 1.12
52 The c-MYC allele that is translocated into the IgH locus undergoes constitutive hypermutation in a Burkitt's lymphoma line. Oncogene 2000 1.11
53 The immunoglobulin (Ig)alpha and Igbeta cytoplasmic domains are independently sufficient to signal B cell maturation and activation in transgenic mice. J Exp Med 1997 1.10
54 A repertoire of monoclonal antibodies with human heavy chains from transgenic mice. Proc Natl Acad Sci U S A 1989 1.08
55 Antigen presentation by the B cell antigen receptor is driven by the alpha/beta sheath and occurs independently of its cytoplasmic tyrosines. Cell 1993 1.08
56 Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice. J Immunol 2000 1.06
57 Mice carrying a CD20 gene disruption. Immunogenetics 1998 1.06
58 Chromosome translocation activates heterogeneously initiated, bipolar transcription of a mouse c-myc gene. EMBO J 1985 1.02
59 Multiple sequences from downstream of the J kappa cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain. Eur J Immunol 1998 1.02
60 Investigations into the Klebsiella aerogenes pentitol operons using specialised transducing phages lambdaprbt and lambdaprbt dal. J Mol Biol 1979 0.98
61 The contribution of somatic hypermutation to the diversity of serum immunoglobulin: dramatic increase with age. Immunity 2000 0.97
62 Production of antibody-tagged enzymes by myeloma cells: application to DNA polymerase I Klenow fragment. Gene 1986 0.93
63 Purification and properties of D-ribulokinase and D-xylulokinase from Klebsiella aerogenes. Biochem J 1981 0.93
64 Antibody repertoires of four- and five-feature translocus mice carrying human immunoglobulin heavy chain and kappa and lambda light chain yeast artificial chromosomes. J Immunol 1999 0.92
65 Strategies for expressing human antibody repertoires in transgenic mice. Immunol Today 1996 0.90
66 Cellular selection leads to age-dependent and reversible down-regulation of transgenic immunoglobulin light chain genes. Int Immunol 1989 0.90
67 Membrane immunoglobulin without sheath or anchor. Mol Immunol 1993 0.88
68 Sequence of a secondary phage lambda attachment site located between the pentitol operons of Klebsiella aerogenes. Biochem J 1981 0.87
69 The diversity of antigen-specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci. Eur J Immunol 1994 0.86
70 Epstein-Barr virus and the somatic hypermutation of immunoglobulin genes in Burkitt's lymphoma cells. J Virol 2001 0.86
71 Maturation of the immune response. Adv Protein Chem 1996 0.85
72 Antibodies generated from human immunoglobulin miniloci in transgenic mice. Nucleic Acids Res 1994 0.84
73 Somatic hypermutation of immunoglobulin kappa transgenes: association of mutability with demethylation. Immunol Cell Biol 2001 0.84
74 Antibody expression from the core region of the human IgH locus reconstructed in transgenic mice using bacteriophage P1 clones. Genomics 1996 0.83
75 In vivo and in vitro studies of immunoglobulin gene somatic hypermutation. Philos Trans R Soc Lond B Biol Sci 2001 0.83
76 The Ig kappa 3'-enhancer triggers gene expression in early B lymphocytes but its activity is enhanced on B cell activation. Int Immunol 1996 0.81
77 Creation of mice expressing human antibody light chains by introduction of a yeast artificial chromosome containing the core region of the human immunoglobulin kappa locus. Biotechnology (N Y) 1993 0.81
78 Regulated activity of the IgH intron enhancer (E mu) in the T lymphocyte lineage. Int Immunol 1995 0.80
79 Production of antigen-specific human monoclonal antibodies: comparison of mice carrying IgH/kappa or IgH/kappa/lambda transloci. Biotechniques 2002 0.79
80 Lymphoid-specific transcriptional activation by components of the IgH enhancer: studies on the E2/E3 and octanucleotide elements. Nucleic Acids Res 1990 0.77
81 Novel antibodies by DNA manipulation. Prog Allergy 1988 0.76
82 Construction, function and immunogenicity of recombinant monoclonal antibodies. Behring Inst Mitt 1990 0.76
83 The expression of immunoglobulin genes. Immunol Today 1988 0.75
84 Minicircular ColE1-related DNA in strains of Klebsiella aerogenes selected for fast growth on xylitol. J Gen Microbiol 1980 0.75
85 Structure of an experimentally evolved gene duplication encoding ribitol dehydrogenase in a mutant of Klebsiella aerogenes. J Gen Microbiol 1981 0.75