Published in Cell on June 01, 1985
Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily conserved repeated motif. Mol Cell Biol (1986) 4.59
Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer. EMBO J (1987) 4.58
Discrete elements within the SV40 enhancer region display different cell-specific enhancer activities. EMBO J (1987) 4.28
Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA). EMBO J (1988) 3.33
A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer. Proc Natl Acad Sci U S A (1987) 3.08
Regulation of rat insulin 1 gene expression: evidence for negative regulation in nonpancreatic cells. Proc Natl Acad Sci U S A (1986) 2.57
The immunoglobulin heavy-chain B-lymphocyte enhancer efficiently stimulates transcription in non-lymphoid cells. EMBO J (1986) 2.56
In vitro binding of cell-specific and ubiquitous nuclear proteins to the octamer motif of the SV40 enhancer and related motifs present in other promoters and enhancers. EMBO J (1987) 2.53
Determinants of rat albumin promoter tissue specificity analyzed by an improved transient expression system. Mol Cell Biol (1987) 2.52
The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region. EMBO J (1989) 2.48
Cell-type preference of immunoglobulin kappa and lambda gene promoters. EMBO J (1985) 2.22
The lysozyme enhancer: cell-specific activation of the chicken lysozyme gene by a far-upstream DNA element. EMBO J (1986) 2.19
Systematic binding analysis of the insulin gene transcription control region: insulin and immunoglobulin enhancers utilize similar transactivators. Mol Cell Biol (1988) 2.13
Negative control of liver-specific gene expression: cloned human retinol-binding protein gene is repressed in HeLa cells. EMBO J (1987) 2.08
Sequences closely related to an immunoglobulin gene promoter/enhancer element occur also upstream of other eukaryotic and of prokaryotic genes. Nucleic Acids Res (1986) 2.03
Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor. EMBO J (1987) 2.02
A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer. Proc Natl Acad Sci U S A (1988) 2.00
Elements required for transcription initiation of the human U2 snRNA gene coincide with elements required for snRNA 3' end formation. EMBO J (1988) 1.97
Functional analysis of the murine IgH enhancer: evidence for negative control of cell-type specificity. Nucleic Acids Res (1986) 1.94
Mutational analysis of the immunoglobulin heavy chain promoter region. Proc Natl Acad Sci U S A (1986) 1.89
Cell-type-specific transcription of an immunoglobulin kappa light chain gene in vitro. Proc Natl Acad Sci U S A (1986) 1.82
Multiple DNA sequence elements are necessary for the function of an immunoglobulin heavy chain promoter. Proc Natl Acad Sci U S A (1987) 1.80
Tissue-specific transcription of the mouse alpha-fetoprotein gene promoter is dependent on HNF-1. Mol Cell Biol (1989) 1.74
A conserved CATTCCT motif is required for skeletal muscle-specific activity of the cardiac troponin T gene promoter. Proc Natl Acad Sci U S A (1988) 1.74
Multiple positive and negative 5' regulatory elements control the cell-type-specific expression of the embryonic skeletal myosin heavy-chain gene. Mol Cell Biol (1987) 1.73
Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer. Mol Cell Biol (1987) 1.71
Cell type-specific negative regulatory element in the control region of the rat alpha-fetoprotein gene. Proc Natl Acad Sci U S A (1986) 1.70
Octamer transcription factors bind to two different sequence motifs of the immunoglobulin heavy chain promoter. EMBO J (1989) 1.70
Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus. Adv Immunol (2008) 1.70
Multiple Oct2 isoforms are generated by alternative splicing. Nucleic Acids Res (1991) 1.65
A conserved sequence in the T-cell receptor beta-chain promoter region. Proc Natl Acad Sci U S A (1988) 1.64
Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer. Mol Cell Biol (1994) 1.61
The intron requirement for immunoglobulin gene expression is dependent upon the promoter. Nucleic Acids Res (1988) 1.60
Activation of octamer-containing promoters by either octamer-binding transcription factor 1 (OTF-1) or OTF-2 and requirement of an additional B-cell-specific component for optimal transcription of immunoglobulin promoters. Mol Cell Biol (1990) 1.58
NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss. Mol Cell Biol (1993) 1.57
The importance of the 3'-enhancer region in immunoglobulin kappa gene expression. Nucleic Acids Res (1990) 1.56
Structural and functional analysis of chicken U4 small nuclear RNA genes. Mol Cell Biol (1986) 1.54
Repression mediates cell-type-specific expression of the rat growth hormone gene. Proc Natl Acad Sci U S A (1986) 1.53
Structure and transcription of the Drosophila mulleri alcohol dehydrogenase genes. Nucleic Acids Res (1985) 1.50
Random activation of a transgene under the control of a hybrid hCD2 locus control region/Ig enhancer regulatory element. EMBO J (1995) 1.49
Promoters with the octamer DNA motif (ATGCAAAT) can be ubiquitous or cell type-specific depending on binding affinity of the octamer site and Oct-factor concentration. Nucleic Acids Res (1991) 1.46
Octamer transcription factors 1 and 2 each bind to two different functional elements in the immunoglobulin heavy-chain promoter. Mol Cell Biol (1989) 1.46
Nuclear factors binding specific sequences within the immunoglobulin enhancer interact differentially with other enhancer elements. EMBO J (1986) 1.45
Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements. Proc Natl Acad Sci U S A (1988) 1.44
Analysis of the upstream regions governing expression of the chicken cardiac troponin T gene in embryonic cardiac and skeletal muscle cells. J Cell Biol (1988) 1.43
Purification of an octamer sequence (ATGCAAAT)-binding protein from human B cells. Nucleic Acids Res (1987) 1.42
Nuclear activity from F9 embryonal carcinoma cells binding specifically to the enhancers of wild-type polyoma virus and PyEC mutant DNAs. Nucleic Acids Res (1986) 1.42
B-cell control region at the 5' end of a major histocompatibility complex class II gene: sequences and factors. Mol Cell Biol (1988) 1.41
Evidence that immunoglobulin VH-DJ recombination does not require germ line transcription of the recombining variable gene segment. Mol Cell Biol (1998) 1.38
A novel upstream element compensates for an ineffectual octamer motif in an immunoglobulin V kappa promoter. EMBO J (1990) 1.36
Complex regulation of the immunoglobulin mu heavy-chain gene enhancer: microB, a new determinant of enhancer function. Mol Cell Biol (1990) 1.31
Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice. Mol Cell Biol (2004) 1.30
trans Activation of the simian virus 40 enhancer. Mol Cell Biol (1986) 1.29
Protein-nucleotide contacts in the immunoglobulin heavy-chain promoter region. Proc Natl Acad Sci U S A (1987) 1.29
A cell type specific factor recognizes the rat thyroglobulin promoter. Nucleic Acids Res (1987) 1.27
Upstream regulatory sequences of immunoglobulin genes are recognized by nuclear proteins which also bind to other gene regions. Nucleic Acids Res (1986) 1.26
The immunoglobulin heavy-chain enhancer functions as the promoter for I mu sterile transcription. Mol Cell Biol (1990) 1.21
Functional redundancy in the tissue-specific enhancer of the Drosophila Sgs-4 gene. EMBO J (1988) 1.21
Expression of T-cell receptor alpha-chain genes in transgenic mice. Mol Cell Biol (1988) 1.20
Involvement of a second lymphoid-specific enhancer element in the regulation of immunoglobulin heavy-chain gene expression. Mol Cell Biol (1990) 1.19
Interaction of a hepatoma-specific nuclear factor with transcription-regulatory sequences of the human alpha-fetoprotein and albumin genes. Mol Cell Biol (1988) 1.19
A cis-acting element and associated binding factor required for CNS expression of the Drosophila melanogaster dopa decarboxylase gene. EMBO J (1988) 1.18
The sequence of the mu transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface. J Exp Med (1990) 1.18
Identification of Ets-like lymphoid specific elements within the immunoglobulin heavy chain 3' enhancer. Nucleic Acids Res (1992) 1.17
Transcription from a murine T-cell receptor V beta promoter depends on a conserved decamer motif similar to the cyclic AMP response element. Mol Cell Biol (1989) 1.16
Immunoglobulin J chain gene from the mouse. Proc Natl Acad Sci U S A (1986) 1.16
Diversity in the germline antibody repertoire. Molecular evolution of the T15 VN gene family. J Exp Med (1985) 1.15
Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator OBF-1. Nucleic Acids Res (1996) 1.13
Multiple nuclear proteins bind upstream sequences in the promotor region of a T-cell receptor beta-chain variable-region gene: evidence for tissue specificity. Proc Natl Acad Sci U S A (1987) 1.13
Conformational alteration of Oct-1 upon DNA binding dictates selectivity in differential interactions with related transcriptional coactivators. Mol Cell Biol (1996) 1.12
Functional elements of the steroid hormone-responsive promoter of mouse mammary tumor virus. J Virol (1990) 1.12
Purified mu EBP-E binds to immunoglobulin enhancers and promoters. Mol Cell Biol (1988) 1.09
Tissue-specific activity of the pro-opiomelanocortin gene promoter. Mol Cell Biol (1987) 1.08
Regulation and a possible stage-specific function of Oct-2 during pre-B-cell differentiation. Mol Cell Biol (1991) 1.07
Muscle-specific activity of the skeletal troponin I promoter requires interaction between upstream regulatory sequences and elements contained within the first transcribed exon. Mol Cell Biol (1990) 1.07
Characterization of immunoglobulin enhancer deletions in murine plasmacytomas. EMBO J (1985) 1.07
Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation. EMBO J (1993) 1.07
The HLA-DQ beta gene upstream region contains an immunoglobulin-like octamer motif that binds cell-type specific nuclear factors. Nucleic Acids Res (1987) 1.06
Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma cell line. Mol Cell Biol (1988) 1.06
Differential regulation of octamer-containing cellular genes by the herpes simplex virus virion protein Vmw65 is mediated by sequence differences in the octamer element. EMBO J (1988) 1.05
Genetic basis for expression of the idiotypic network. One unique Ig VH germline gene accounts for the major family of Ab1 and Ab3 (Ab1') antibodies of the GAT system. J Exp Med (1986) 1.04
Functional analysis of elements affecting expression of the beta-actin gene of carp. Mol Cell Biol (1990) 1.03
B cell development and immunoglobulin transcription in Oct-1-deficient mice. Proc Natl Acad Sci U S A (2004) 1.03
IgM receptor-mediated transactivation of the IgH 3' enhancer couples a novel Elf-1-AP-1 protein complex to the developmental control of enhancer function. EMBO J (1995) 1.03
Multiple functional motifs in the chicken U1 RNA gene enhancer. Mol Cell Biol (1987) 1.02
The B-cell and neuronal forms of the octamer-binding protein Oct-2 differ in DNA-binding specificity and functional activity. Mol Cell Biol (1991) 1.02
Nuclear factors binding to the human immunoglobulin heavy-chain gene enhancer. Nucleic Acids Res (1987) 1.01
Immunoglobulin heavy chain locus of the rat: striking homology to mouse antibody genes. Proc Natl Acad Sci U S A (1986) 1.00
New B-lymphocyte-specific enhancer-binding protein. Mol Cell Biol (1989) 1.00
Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription. EMBO J (1997) 0.98
Cell cycle regulation of H2b histone octamer DNA-binding activity in Chinese hamster lung fibroblasts. Mol Cell Biol (1989) 0.98
Lineage-specific expression of a T cell receptor variable gene promoter controlled by upstream sequences. J Exp Med (1989) 0.98
In vitro transcription of immunoglobulin genes in a B-cell extract: effects of enhancer and promoter sequences. Mol Cell Biol (1987) 0.96
Cell lineage specificity of chromatin configuration around the immunoglobulin heavy chain enhancer. EMBO J (1988) 0.95
The Ets factor Spi-B is a direct critical target of the coactivator OBF-1. Proc Natl Acad Sci U S A (2006) 0.94
Transcription of HLA class II genes in the absence of B-cell-specific octamer-binding factor. Mol Cell Biol (1988) 0.92
Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature (1989) 6.70
Mechanism of antigen-driven selection in germinal centres. Nature (1990) 5.26
Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature (1986) 4.19
Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies. J Exp Med (1987) 3.82
GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer. Oncogene (2008) 3.79
Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis. Nature (1991) 3.61
B cells acquire antigen from target cells after synapse formation. Nature (2001) 3.31
Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate. Immunity (1998) 3.27
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity (1998) 3.16
Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation. Nature (2001) 3.09
Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell (1994) 3.06
Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative. J Clin Pathol (1997) 2.98
Transdermal nicotine for active ulcerative colitis. N Engl J Med (1994) 2.90
Hyperresponsive B cells in CD22-deficient mice. Science (1996) 2.86
TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity (1998) 2.76
Gastrointestinal manifestations of type 1 neurofibromatosis (von Recklinghausen's disease). Histopathology (1991) 2.75
A hapten-specific chimaeric IgE antibody with human physiological effector function. Nature (1985) 2.63
Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation. EMBO J (1999) 2.58
The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region. EMBO J (1989) 2.48
Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice. Nucleic Acids Res (1997) 2.44
Colorectal cancer pathology reporting: a regional audit. J Clin Pathol (1997) 2.41
Preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imaging. Br J Surg (2003) 2.40
Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc Natl Acad Sci U S A (1993) 2.30
Apoptosis: molecular regulation of cell death. Eur J Biochem (1996) 2.29
Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis. Gut (1994) 2.28
Demonstration of somatic mutation and colonic crypt clonality by X-linked enzyme histochemistry. Nature (1988) 2.28
Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter. Mol Cell Biol (1987) 2.17
Granulomatous inflammation--a review. J Clin Pathol (1983) 2.15
Activation of mouse complement by monoclonal mouse antibodies. Eur J Immunol (1981) 2.11
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Squamous carcinoma of the colorectum and its genesis. J Pathol (1979) 2.07
The B-cell antigen receptor of the five immunoglobulin classes. Nature (1991) 1.97
Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response. Proc Natl Acad Sci U S A (1998) 1.94
Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol Today (1993) 1.93
The implementation of guidelines and computerised forms improves the completeness of cancer pathology reporting. The CROPS project: a randomised controlled trial in pathology. Eur J Cancer (2002) 1.88
Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies. J Exp Med (1999) 1.83
Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes. EMBO J (1991) 1.83
Regulation of membrane IgM expression in secretory B cells: translational and post-translational events. EMBO J (1987) 1.82
Rectal carcinoma: thin-section MR imaging for staging in 28 patients. Radiology (1999) 1.82
Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature (1995) 1.80
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Recombinant antibodies possessing novel effector functions. Nature (1985) 1.76
Somatic hypermutation of immunoglobulin genes. Annu Rev Immunol (1996) 1.72
Codon bias targets mutation. Nature (1995) 1.69
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Detection of three protein binding sites in the serum-regulated promoter of the human gene encoding the 70-kDa heat shock protein. Proc Natl Acad Sci U S A (1987) 1.60
Antigen-induced apoptosis in developing T cells: a mechanism for negative selection of the T cell receptor repertoire. Eur J Immunol (1989) 1.58
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Purification and properties of Klebsiella aerogenes D-arabitol dehydrogenase. Biochem J (1979) 1.38
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