Published in Bioarchitecture on August 06, 2014
Mutations in Genes Associated With Pentalogy of Cantrell | NCT00083499
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The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway. Blood (2007) 1.64
Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain. J Comp Neurol (2001) 1.63
Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice. J Thromb Haemost (2010) 1.57
Apical abscission alters cell polarity and dismantles the primary cilium during neurogenesis. Science (2014) 1.57
Myosin II is required for interkinetic nuclear migration of neural progenitors. Proc Natl Acad Sci U S A (2009) 1.53
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Mutations in human nonmuscle myosin IIA found in patients with May-Hegglin anomaly and Fechtner syndrome result in impaired enzymatic function. J Biol Chem (2002) 1.44
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Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis. Mol Biol Cell (2010) 1.36
Embryology, sternal clefts, ectopia cordis, and Cantrell's pentalogy. Semin Pediatr Surg (2008) 1.35
Morphogenetic movements driving neural tube closure in Xenopus require myosin IIB. Dev Biol (2008) 1.34
Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease. Hum Mutat (2008) 1.34
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Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells. Cell Stem Cell (2013) 1.30
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NMII forms a contractile transcellular sarcomeric network to regulate apical cell junctions and tissue geometry. Curr Biol (2013) 1.29
Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion. Blood (2007) 1.29
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Characterization of three full-length human nonmuscle myosin II paralogs. J Biol Chem (2013) 1.23
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A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors. Nat Neurosci (2012) 1.12
Leading tip drives soma translocation via forward F-actin flow during neuronal migration. J Neurosci (2010) 1.07
Conditional ablation of nonmuscle myosin II-B delineates heart defects in adult mice. Circ Res (2009) 1.03
Molecular mechanisms of cell shape changes that contribute to vertebrate neural tube closure. Dev Growth Differ (2012) 1.03
Function of the neuron-specific alternatively spliced isoforms of nonmuscle myosin II-B during mouse brain development. Mol Biol Cell (2006) 1.02
BRCA2 localization to the midbody by filamin A regulates cep55 signaling and completion of cytokinesis. Dev Cell (2012) 1.02
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MYH9-related disease: five novel mutations expanding the spectrum of causative mutations and confirming genotype/phenotype correlations. Eur J Med Genet (2012) 1.00
An alternatively spliced isoform of non-muscle myosin II-C is not regulated by myosin light chain phosphorylation. J Biol Chem (2009) 0.97
The heavy chain has its day: regulation of myosin-II assembly. Bioarchitecture (2014) 0.94
Molecular organization and alternative splicing in zipper, the gene that encodes the Drosophila non-muscle myosin II heavy chain. J Mol Biol (1996) 0.92
Comparative kinetic and functional characterization of the motor domains of human nonmuscle myosin-2C isoforms. J Biol Chem (2011) 0.92
Clinical, pathological, and genetic analysis of ten patients with MYH9-related disease. Acta Haematol (2012) 0.91
The B2 alternatively spliced isoform of nonmuscle myosin II-B lacks actin-activated MgATPase activity and in vitro motility. Biochem Biophys Res Commun (2007) 0.89
The tumor suppressor Lgl1 forms discrete complexes with NMII-A and Par6α-aPKCζ that are affected by Lgl1 phosphorylation. J Cell Sci (2013) 0.87
Nonmuscle myosin heavy chain IIA is a critical factor contributing to the efficiency of early infection of severe fever with thrombocytopenia syndrome virus. J Virol (2013) 0.87
BRCA2 phosphorylated by PLK1 moves to the midbody to regulate cytokinesis mediated by nonmuscle myosin IIC. Cancer Res (2014) 0.85
A complex phenotype of peripheral neuropathy, myopathy, hoarseness, and hearing loss is linked to an autosomal dominant mutation in MYH14. Hum Mutat (2011) 0.84
Alternative splice variants of MYH9. DNA Cell Biol (2008) 0.84
A human de novo mutation in MYH10 phenocopies the loss of function mutation in mice. Rare Dis (2013) 0.84
Spectrum of Cantrell's pentalogy: case series from a single tertiary care center and review of the literature. Pediatr Cardiol (2013) 0.84
The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition. J Thromb Haemost (2013) 0.83
Establishment of mouse model of MYH9 disorders: heterozygous R702C mutation provokes macrothrombocytopenia with leukocyte inclusion bodies, renal glomerulosclerosis and hearing disability. PLoS One (2013) 0.82
A point mutation in Myh10 causes major defects in heart development and body wall closure. Circ Cardiovasc Genet (2014) 0.82
MYH9 related disease: a novel missense Ala95Asp mutation of the MYH9 gene. Platelets (2009) 0.82
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Non-muscle myosin IIB is essential for cytokinesis during male meiotic cell divisions. Dev Biol (2012) 0.79
Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality. Dev Biol (2013) 0.77
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