Published in Biol Reprod on August 06, 2014
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99
Inflammation and metabolic disorders. Nature (2006) 33.33
AKT/PKB signaling: navigating downstream. Cell (2007) 31.26
Cellular survival: a play in three Akts. Genes Dev (1999) 17.05
Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst (2000) 16.92
Integrated genomic characterization of endometrial carcinoma. Nature (2013) 14.29
Pten is essential for embryonic development and tumour suppression. Nat Genet (1998) 13.41
Endometriosis. Lancet (2004) 8.41
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell (2011) 7.32
Endometriosis. N Engl J Med (2009) 6.82
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science (1998) 6.79
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol (1998) 6.38
The two TORCs and Akt. Dev Cell (2007) 6.17
Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J (1990) 5.05
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discov (2011) 4.78
Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell (2011) 4.43
Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. J Biol Chem (2001) 3.86
Molecular pathology of endometrial hyperplasia and carcinoma. Hum Pathol (2001) 3.80
Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors. Proc Natl Acad Sci U S A (2004) 3.49
Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J (2002) 3.27
Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion. Nat Clin Pract Urol (2009) 3.24
Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis. Endocrinology (2007) 2.95
Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol (1993) 2.89
Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility. Endocrinology (2003) 2.80
The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice. Genes Dev (2006) 2.76
Physiological action of progesterone in target tissues. Endocr Rev (1997) 2.73
Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches. Oncogene (2013) 2.64
Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform. Science (2000) 2.57
Role of stromal-epithelial interactions in hormonal responses. Arch Histol Cytol (2004) 2.55
Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium. Proc Natl Acad Sci U S A (1997) 2.54
The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2. Science (2011) 2.46
Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Proc Natl Acad Sci U S A (2001) 2.45
Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients. Br J Cancer (2002) 2.44
A general mechanism for transcriptional synergy by eukaryotic activators. Nature (1995) 2.29
Immunobiology of endometriosis. Fertil Steril (2001) 2.29
HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway. Cancer Res (2000) 2.25
A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas. Clin Cancer Res (2011) 2.24
AKT activation predicts outcome in breast cancer patients treated with tamoxifen. J Pathol (2005) 2.20
The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells. Mol Endocrinol (2005) 2.19
Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res (2008) 2.15
Forkhead box proteins: tuning forks for transcriptional harmony. Nat Rev Cancer (2013) 2.02
Physiological functions of protein kinase B/Akt. Biochem Soc Trans (2004) 2.00
The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Cancer Control (2009) 1.96
Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor. Proc Natl Acad Sci U S A (2006) 1.93
Progesterone receptor isoform A but not B is expressed in endometriosis. J Clin Endocrinol Metab (2000) 1.92
Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer. Endocr Rev (2013) 1.91
PIK3R1 (p85α) is somatically mutated at high frequency in primary endometrial cancer. Cancer Res (2011) 1.91
The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. Mol Cell Biol (2000) 1.83
Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors. Mol Endocrinol (1993) 1.78
Progesterone resistance in endometriosis: link to failure to metabolize estradiol. Mol Cell Endocrinol (2006) 1.77
Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells. J Clin Endocrinol Metab (1997) 1.73
The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas. Br J Cancer (2009) 1.70
Inflammation and endometrial cancer: a hypothesis. Cancer Epidemiol Biomarkers Prev (2005) 1.68
Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women. J Clin Oncol (2007) 1.66
Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: a dose-response study by the Gynecologic Oncology Group. J Clin Oncol (1999) 1.66
Hormonal therapy for the management of grade 1 endometrial adenocarcinoma: a literature review. Gynecol Oncol (2004) 1.63
The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor. Mol Cell Biol (1998) 1.61
Integration of the non-genomic and genomic actions of estrogen. Membrane-initiated signaling by steroid to transcription and cell biology. J Biol Chem (2002) 1.60
Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses. Proc Natl Acad Sci U S A (2010) 1.54
Role of progesterone in endometrial cancer. Semin Reprod Med (2010) 1.53
Progesterone: the ultimate endometrial tumor suppressor. Trends Endocrinol Metab (2011) 1.46
Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells. Mol Endocrinol (2007) 1.45
Progestin treatment of atypical hyperplasia and well-differentiated carcinoma of the endometrium in women under age 40. Obstet Gynecol (1997) 1.42
Akt kinases in breast cancer and the results of adjuvant therapy. Breast Cancer Res (2003) 1.41
Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis. J Clin Endocrinol Metab (2008) 1.41
Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity. Hum Mol Genet (2007) 1.40
Mechanism and functional consequences of loss of FOXO1 expression in endometrioid endometrial cancer cells. Oncogene (2007) 1.40
Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity. Fertil Steril (2006) 1.40
FOXO1A differentially regulates genes of decidualization. Endocrinology (2006) 1.39
Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization. Mol Endocrinol (2006) 1.37
Promoter hypermethylation of progesterone receptor isoform B (PR-B) in endometriosis. Epigenetics (2006) 1.36
Endometrial stromal cells regulate epithelial cell growth in vitro: a new co-culture model. Hum Reprod (2001) 1.34
The management of endometrial hyperplasia: an evaluation of current practice. Eur J Obstet Gynecol Reprod Biol (2005) 1.29
The biologic significance of cytologic atypia in progestogen-treated endometrial hyperplasia. Am J Obstet Gynecol (1989) 1.26
Hormone therapy in advanced and recurrent endometrial cancer: a systematic review. Int J Gynecol Cancer (2007) 1.25
Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo. Mol Endocrinol (1999) 1.23
Progestin alone as primary treatment of endometrial carcinoma in premenopausal women. Report of seven cases and review of the literature. Cancer (1997) 1.23
Steroidogenic enzyme and key decidualization marker dysregulation in endometrial stromal cells from women with versus without endometriosis. Biol Reprod (2008) 1.22
Role of FOXO1A in the regulation of insulin-like growth factor-binding protein-1 in human endometrial cells: interaction with progesterone receptor. Biol Reprod (2005) 1.22
Regulation of insulin-like growth factor binding protein-1 promoter activity by FKHR and HOXA10 in primate endometrial cells. Biol Reprod (2003) 1.22
AKT alters genome-wide estrogen receptor alpha binding and impacts estrogen signaling in breast cancer. Mol Cell Biol (2008) 1.21
Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-B. Mol Endocrinol (2006) 1.17
The association between Akt activation and resistance to hormone therapy in metastatic breast cancer. Eur J Cancer (2006) 1.16
The effectiveness of a levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of endometrial hyperplasia--a long-term follow-up study. Eur J Obstet Gynecol Reprod Biol (2008) 1.16
Use of immunocytochemistry of progesterone and estrogen receptors for endometrial dating. J Clin Endocrinol Metab (1988) 1.16
The regulation and function of the forkhead transcription factor, Forkhead box O1, is dependent on the progesterone receptor in endometrial carcinoma. Endocrinology (2007) 1.14
Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium. Proc Natl Acad Sci U S A (2010) 1.13
Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins. Am J Surg Pathol (2007) 1.13
Reduced progesterone action during endometrial maturation: a potential risk factor for the development of endometriosis. Fertil Steril (2005) 1.13
Synergistic targeting of PI3K/AKT pathway and androgen receptor axis significantly delays castration-resistant prostate cancer progression in vivo. Mol Cancer Ther (2013) 1.12
The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity. J Steroid Biochem Mol Biol (1994) 1.12
Progesterone receptor B gene inactivation and CpG hypermethylation in human uterine endometrial cancer. Cancer Res (2001) 1.11
Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice. Cancer Res (2006) 1.07
Increased mitogen-activated protein kinase kinase/extracellularly regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis reduces 3',5'-cyclic adenosine 5'-monophosphate inhibition of cyclin D1. Endocrinology (2009) 1.07
Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells. Cell Cycle (2013) 1.07
Interleukin-8 concentrations are elevated in peritoneal fluid of women with endometriosis. Fertil Steril (1995) 1.04
Effect of normal endometrial stroma on growth and differentiation in Ishikawa endometrial adenocarcinoma cells. Cancer Res (2002) 1.03
Inhibition of AKT with the orally active allosteric AKT inhibitor, MK-2206, sensitizes endometrial cancer cells to progestin. PLoS One (2012) 1.03
The subunit structure of human breast cancer progesterone receptors: characterization by chromatography and photoaffinity labeling. Endocrinology (1983) 1.03