Inflammation and metabolic disorders.

Macrophage plasticity and polarization: in vivo veritas. J Clin Invest (2012) 13.44

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature (2007) 11.59

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med (2009) 11.28

Autophagy in immunity and inflammation. Nature (2011) 11.16

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell (2010) 10.96

Complement: a key system for immune surveillance and homeostasis. Nat Immunol (2010) 10.37

Adipokines in inflammation and metabolic disease. Nat Rev Immunol (2011) 8.92

Macrophage biology in development, homeostasis and disease. Nature (2013) 8.28

Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med (2009) 8.15

Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell (2010) 8.04

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med (2011) 8.00

Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell (2008) 7.37

From endoplasmic-reticulum stress to the inflammatory response. Nature (2008) 7.17

Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science (2011) 6.83

Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell (2008) 6.83

Inflammatory links between obesity and metabolic disease. J Clin Invest (2011) 6.73

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol (2011) 6.53

Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab (2008) 5.83

Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab (2010) 5.82

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov (2008) 5.78

The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol (2011) 5.73

Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol (2008) 5.61

Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab (2008) 5.53

Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology (2010) 5.35

The role of exercise and PGC1alpha in inflammation and chronic disease. Nature (2008) 5.31

Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A (2008) 5.21

Transcriptional control of the inflammatory response. Nat Rev Immunol (2009) 5.20

Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest (2007) 4.86

Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation (2009) 4.71

Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol (2011) 4.68

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature (2007) 4.59

Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. Psychol Bull (2011) 4.27

Sweetened beverage consumption, incident coronary heart disease, and biomarkers of risk in men. Circulation (2012) 4.24

Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science (2010) 4.15

Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature (2010) 4.12

Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell (2010) 4.01

The protein kinase IKKepsilon regulates energy balance in obese mice. Cell (2009) 3.93

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell (2008) 3.91

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev (2008) 3.90

Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet (2010) 3.63

Alternative macrophage activation and metabolism. Annu Rev Pathol (2011) 3.59

The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial. Ann Intern Med (2010) 3.56

Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes (2008) 3.47

Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res (2008) 3.47

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell (2014) 3.44

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat Med (2009) 3.43

Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. Arch Pediatr Adolesc Med (2009) 3.41

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling. Proc Natl Acad Sci U S A (2011) 3.35

Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes (2009) 3.27

Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes. Proc Natl Acad Sci U S A (2012) 3.27

Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assembly. Nat Med (2013) 3.24

Primary prevention of colorectal cancer. Gastroenterology (2010) 3.20

Emerging role of adipose tissue hypoxia in obesity and insulin resistance. Int J Obes (Lond) (2008) 3.17

Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB. Nat Med (2011) 3.15

The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab (2010) 3.11

Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol (2009) 3.09

Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women. Gut (2012) 3.09

Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles (2015) 3.02

Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies. Lancet (2008) 2.96

Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab (2012) 2.96

Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis (2008) 2.89

Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages. J Biol Chem (2008) 2.87

Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. Am J Physiol Gastrointest Liver Physiol (2010) 2.84

Diacylglycerol-mediated insulin resistance. Nat Med (2010) 2.82

Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity (2012) 2.80

In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. J Clin Invest (2008) 2.78

The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol (2011) 2.77

Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest (2007) 2.73

Inflammatory mechanisms in the regulation of insulin resistance. Mol Med (2008) 2.71

Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta (2008) 2.67

Self-reported sleep duration is associated with the metabolic syndrome in midlife adults. Sleep (2008) 2.60

A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation? Nat Immunol (2012) 2.59

Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest (2008) 2.55

Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin Transl Sci (2008) 2.54

HSP72 protects against obesity-induced insulin resistance. Proc Natl Acad Sci U S A (2008) 2.52

Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell (2010) 2.50

"Control" laboratory rodents are metabolically morbid: why it matters. Proc Natl Acad Sci U S A (2010) 2.50

Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota. Gut (2011) 2.50

Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes. Pflugers Arch (2007) 2.39

Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii. Int J Obes (Lond) (2011) 2.39

IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Proc Natl Acad Sci U S A (2010) 2.37

TNF-alpha and adipocyte biology. FEBS Lett (2007) 2.37

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36

Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes (2009) 2.36

Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell (2007) 2.35

Control of macrophage activation and function by PPARs. Circ Res (2010) 2.34

Uric acid transport and disease. J Clin Invest (2010) 2.33

Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes. Science (2013) 2.32

Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol (2010) 2.28

A role of miR-27 in the regulation of adipogenesis. FEBS J (2009) 2.27

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab (2009) 2.25

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol Med (2011) 2.25

Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res (2007) 2.25

Mechanisms of macrophage activation in obesity-induced insulin resistance. Nat Clin Pract Endocrinol Metab (2008) 2.24

Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol (2008) 2.22

GAPDH mediates nitrosylation of nuclear proteins. Nat Cell Biol (2010) 2.22

Sphingolipid metabolites in inflammatory disease. Nature (2014) 2.19

Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J Biol Chem (2010) 2.19

Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm (2010) 2.18

Metabonomic, transcriptomic, and genomic variation of a population cohort. Mol Syst Biol (2010) 2.17