Endoplasmic reticulum stress and endothelial dysfunction.

Vascular biology of ageing-Implications in hypertension. J Mol Cell Cardiol (2015) 1.01

Reactive Oxygen Species, Endoplasmic Reticulum Stress and Mitochondrial Dysfunction: The Link with Cardiac Arrhythmogenesis. Front Physiol (2016) 0.93

Uric acid enhances PKC-dependent eNOS phosphorylation and mediates cellular ER stress: A mechanism for uric acid-induced endothelial dysfunction. Int J Mol Med (2016) 0.83

RhoA/mDia-1/profilin-1 signaling targets microvascular endothelial dysfunction in diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol (2015) 0.82

Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension. J Clin Invest (2016) 0.78

Causes and consequences of endoplasmic reticulum stress in rheumatic disease. Nat Rev Rheumatol (2016) 0.77

Intravenous Lipid Infusion Induces Endoplasmic Reticulum Stress in Endothelial Cells and Blood Mononuclear Cells of Healthy Adults. J Am Heart Assoc (2016) 0.76

Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus. Front Physiol (2016) 0.76

Attenuation of endoplasmic reticulum stress by caffeine ameliorates hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol (2017) 0.75

Plasma from pre-pubertal obese children impairs insulin stimulated Nitric Oxide (NO) bioavailability in endothelial cells: Role of ER stress. Mol Cell Endocrinol (2017) 0.75

ER stress and impaired autophagy flux in neuronal degeneration and brain injury. Ageing Res Rev (2016) 0.75

Protective Effect of Enalapril against Methionine-Enriched Diet-Induced Hypertension: Role of Endoplasmic Reticulum and Oxidative Stress. Biomed Res Int (2015) 0.75

β-aminoisobutyric acid attenuates hepatic endoplasmic reticulum stress and glucose/lipid metabolic disturbance in mice with type 2 diabetes. Sci Rep (2016) 0.75

Equol Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice by Inhibiting Endoplasmic Reticulum Stress via Activation of Nrf2 in Endothelial Cells. PLoS One (2016) 0.75

Adiporedoxin suppresses endothelial activation via inhibiting MAPK and NF-κB signaling. Sci Rep (2016) 0.75

Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum. Front Pharmacol (2017) 0.75

Role of PGC-1α in Vascular Regulation: Implications for Atherosclerosis. Arterioscler Thromb Vasc Biol (2016) 0.75

IL-1β Inhibition in Cardiovascular Complications Associated to Diabetes Mellitus. Front Pharmacol (2017) 0.75

The unfolded protein response: from stress pathway to homeostatic regulation. Science (2011) 15.71

The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol (2012) 8.52

The impact of the unfolded protein response on human disease. J Cell Biol (2012) 4.36

Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease. Cell Death Differ (2004) 2.59

The role of endoplasmic reticulum stress in the progression of atherosclerosis. Circ Res (2010) 2.44

Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. Blood (1999) 2.08

Role of endoplasmic reticulum stress in metabolic disease and other disorders. Annu Rev Med (2012) 1.98

Endothelial dysfunction as a target for prevention of cardiovascular disease. Diabetes Care (2009) 1.91

VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress. Mol Cell (2014) 1.83

A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus. Hypertension (2012) 1.78

Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy. FEBS Lett (2009) 1.65

Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response. J Biol Chem (2001) 1.61

TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia. J Biol Chem (2003) 1.61

Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo. Circulation (2010) 1.58

Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression. Circ Res (2008) 1.56

Transcriptional regulation of VEGF-A by the unfolded protein response pathway. PLoS One (2010) 1.52

ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension. J Clin Invest (2012) 1.51

The vascular endothelium and human diseases. Int J Biol Sci (2013) 1.49

Unfolded protein response signaling and metabolic diseases. J Biol Chem (2013) 1.48

ER stress-induced inflammation: does it aid or impede disease progression? Trends Mol Med (2012) 1.41

A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis. Cancer Res (2011) 1.40

Endoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice. Arterioscler Thromb Vasc Biol (2012) 1.37

Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo. Diabetes (2010) 1.36

The endoplasmic reticulum-mitochondria connection: one touch, multiple functions. Biochim Biophys Acta (2013) 1.32

Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases. A mechanistic clue to the 'response to injury' hypothesis. Circulation (1997) 1.31

The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo. Cardiovasc Res (2013) 1.30

When ER stress reaches a dead end. Biochim Biophys Acta (2013) 1.28

Reactive oxygen and nitrogen species in pulmonary hypertension. Free Radic Biol Med (2012) 1.19

New functions of mitochondria associated membranes in cellular signaling. Biochim Biophys Acta (2014) 1.17

A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis. J Exp Med (2012) 1.14

Cellular and molecular aspects of vascular dysfunction in systemic sclerosis. Nat Rev Rheumatol (2010) 1.08

Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway. Arterioscler Thromb Vasc Biol (2014) 1.07

Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension. Circulation (2012) 1.06

HDLs inhibit endoplasmic reticulum stress and autophagic response induced by oxidized LDLs. Cell Death Differ (2010) 1.06

Endoplasmic reticulum stress and Nox-mediated reactive oxygen species signaling in the peripheral vasculature: potential role in hypertension. Antioxid Redox Signal (2013) 1.04

Endothelial dysfunction in diabetes mellitus: possible involvement of endoplasmic reticulum stress? Exp Diabetes Res (2012) 1.02

Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy. Cell Mol Life Sci (2013) 0.96

Suppression of endoplasmic reticulum stress improves endothelium-dependent contractile responses in aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol (2013) 0.95

Phospholipolyzed LDL induces an inflammatory response in endothelial cells through endoplasmic reticulum stress signaling. FASEB J (2010) 0.92

Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes. Diabetologia (2012) 0.92

Reduction of endoplasmic reticulum stress by 4-phenylbutyric acid prevents the development of hypoxia-induced pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol (2014) 0.90

Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice. J Pathol (2012) 0.87

Glucose-induced endoplasmic reticulum stress is independent of oxidative stress: A mechanistic explanation for the failure of antioxidant therapy in diabetes. Free Radic Biol Med (2011) 0.86

Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension. Arthritis Rheum (2013) 0.85

Triglyceride-rich lipoprotein modulates endothelial vascular cell adhesion molecule (VCAM)-1 expression via differential regulation of endoplasmic reticulum stress. PLoS One (2013) 0.84

Endoplasmic reticulum stress and angiogenesis: is there an interaction between them? Liver Int (2014) 0.82

Induction of endoplasmic reticulum stress impairs insulin-stimulated vasomotor relaxation in rat aortic rings: role of endothelin-1. J Physiol Pharmacol (2013) 0.82

Endothelial GATA-6 deficiency promotes pulmonary arterial hypertension. Am J Pathol (2013) 0.81

HLA-B35 and dsRNA induce endothelin-1 via activation of ATF4 in human microvascular endothelial cells. PLoS One (2013) 0.80

Deficiency of TDAG51 protects against atherosclerosis by modulating apoptosis, cholesterol efflux, and peroxiredoxin-1 expression. J Am Heart Assoc (2013) 0.79

Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med (2013) 3.81

Ets proteins in biological control and cancer. J Cell Biochem (2004) 2.24

Blockade of the effects of TGF-beta1 on mesangial cells by overexpression of Smad7. J Am Soc Nephrol (2002) 2.22

Dedicated epithelial recipient cells determine pigmentation patterns. Cell (2007) 1.78

Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy (2008) 1.78

Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways. J Biol Chem (2007) 1.73

Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin. Am J Pathol (2003) 1.57

Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts. Arthritis Rheum (2006) 1.57

Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program. J Biol Chem (2006) 1.49

Opposing effects of protein kinase Calpha and protein kinase Cepsilon on collagen expression by human lung fibroblasts are mediated via MEK/ERK and caveolin-1 signaling. J Biol Chem (2005) 1.44

TGF-beta and CTGF have overlapping and distinct fibrogenic effects on human renal cells. Am J Physiol Renal Physiol (2002) 1.38

Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts. Am J Respir Cell Mol Biol (2003) 1.38

Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy. Am J Pathol (2010) 1.37

Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta. J Biol Chem (2002) 1.35

Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning. Autophagy (2012) 1.34

Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning. Autophagy (2010) 1.28

Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1. Oncogene (2004) 1.24

ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. J Biol Chem (2008) 1.21

Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate. Arthritis Rheum (2008) 1.20

Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway. J Biol Chem (2004) 1.19

Transforming growth factor-beta regulates DNA binding activity of transcription factor Fli1 by p300/CREB-binding protein-associated factor-dependent acetylation. J Biol Chem (2007) 1.19

Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. J Biol Chem (2004) 1.18

An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionarily conserved enhancer. Mol Cell Biol (2006) 1.13

Recent advances in fibroblast signaling and biology in scleroderma. Curr Opin Rheumatol (2004) 1.13

Fibroblast expression of the coactivator p300 governs the intensity of profibrotic response to transforming growth factor beta. Arthritis Rheum (2005) 1.12

p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum. Autophagy (2009) 1.11

An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid. Autophagy (2007) 1.10

Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. FASEB J (2005) 1.09

Phosphorylation of Fli1 at threonine 312 by protein kinase C delta promotes its interaction with p300/CREB-binding protein-associated factor and subsequent acetylation in response to transforming growth factor beta. Mol Cell Biol (2009) 1.09

A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. J Clin Invest (2009) 1.09

CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network. PLoS One (2011) 1.09

Fibrosis in systemic sclerosis. Rheum Dis Clin North Am (2008) 1.08

Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts. J Invest Dermatol (2008) 1.08

An increased transforming growth factor beta receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor beta receptor type II in scleroderma. Arthritis Rheum (2004) 1.06

Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway. J Biol Chem (2008) 1.06

Reversal of activation of human myofibroblast-like cells by culture on a basement membrane-like substrate. J Hepatol (2002) 1.05

Transcription factor Fli1 regulates collagen fibrillogenesis in mouse skin. Mol Cell Biol (2008) 1.05

Role of p38 MAPK in transforming growth factor beta stimulation of collagen production by scleroderma and healthy dermal fibroblasts. J Invest Dermatol (2002) 1.04

Distinct effects of gonadectomy in male and female mice on collagen fibrillogenesis in the skin. J Dermatol Sci (2007) 1.04

p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7. J Biol Chem (2009) 1.04

Endoglin promotes TGF-β/Smad1 signaling in scleroderma fibroblasts. J Cell Physiol (2011) 1.03

The role of endoplasmic reticulum stress and the unfolded protein response in fibrosis. Curr Opin Rheumatol (2012) 1.03

Increased levels of transforming growth factor beta receptor type I and up-regulation of matrix gene program: A model of scleroderma. Arthritis Rheum (2006) 1.02

Down-regulation of Bcl-2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum. J Neurosci Res (2009) 1.02

Opiate and acetylcholine-independent analgesic actions of crotoxin isolated from crotalus durissus terrificus venom. Toxicon (2006) 1.00

Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway. J Ethnopharmacol (2010) 0.97

Different effects of valproate on methamphetamine- and cocaine-induced behavioral sensitization in mice. Behav Brain Res (2005) 0.97

Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts. Arthritis Rheum (2003) 0.95

Angiotensin II induces skin fibrosis: a novel mouse model of dermal fibrosis. Arthritis Res Ther (2012) 0.95

Helicobacter pylori-induced H,K-ATPase alpha-subunit gene repression is mediated by NF-kappaB p50 homodimer promoter binding. Am J Physiol Gastrointest Liver Physiol (2008) 0.94

Mechanisms of low-density lipoprotein-induced expression of connective tissue growth factor in human aortic endothelial cells. Am J Physiol Heart Circ Physiol (2005) 0.94

Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts. Exp Dermatol (2010) 0.94

NF-kappaB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53. Brain Res (2007) 0.93

The c-Abl tyrosine kinase controls protein kinase Cδ-induced Fli-1 phosphorylation in human dermal fibroblasts. Arthritis Rheum (2011) 0.93

A long-form alpha-neurotoxin from cobra venom produces potent opioid-independent analgesia. Acta Pharmacol Sin (2006) 0.93

Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators. J Biol Chem (2003) 0.93

Lysophosphatidic acid inhibits TGF-beta-mediated stimulation of type I collagen mRNA stability via an ERK-dependent pathway in dermal fibroblasts. Matrix Biol (2004) 0.93

Enhancement of neuroprotection and heat shock protein induction by combined prostaglandin A1 and lithium in rodent models of focal ischemia. Brain Res (2006) 0.93

Genetic variant in the promoter of connective tissue growth factor gene confers susceptibility to nephropathy in type 1 diabetes. J Med Genet (2010) 0.92

HLA-B35 upregulates endothelin-1 and downregulates endothelial nitric oxide synthase via endoplasmic reticulum stress response in endothelial cells. J Immunol (2010) 0.92

Suppression of complete Freund's adjuvant-induced adjuvant arthritis by cobratoxin. Acta Pharmacol Sin (2009) 0.91

Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells. Carcinogenesis (2008) 0.91

Endothelial cells recruit macrophages and contribute to a fibrotic milieu in bleomycin lung injury. Am J Respir Cell Mol Biol (2013) 0.90

Interferon-γ promotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) β2. J Cell Physiol (2013) 0.89

Platelet derived growth factor induced tenascin-C transcription is phosphoinositide 3-kinase/Akt-dependent and mediated by Ets family transcription factors. J Cell Physiol (2006) 0.88

Autocrine transforming growth factor β signaling regulates extracellular signal-regulated kinase 1/2 phosphorylation via modulation of protein phosphatase 2A expression in scleroderma fibroblasts. Fibrogenesis Tissue Repair (2010) 0.88

The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning. Acta Pharmacol Sin (2013) 0.88

Adenosine A(2A) receptors promote collagen production by a Fli1- and CTGF-mediated mechanism. Arthritis Res Ther (2013) 0.88

The Role of TGF-β Receptors in Fibrosis. Open Rheumatol J (2012) 0.87

p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms. Eur J Neurosci (2009) 0.87

Endophyte-mediated effects on the growth and physiology of Achnatherum sibiricum are conditional on both N and P availability. PLoS One (2012) 0.87

The pro-survival role of autophagy depends on Bcl-2 under nutrition stress conditions. PLoS One (2013) 0.87

Genetic factors in systemic sclerosis. Arthritis Res Ther (2007) 0.86

The impact of Fli1 deficiency on the pathogenesis of systemic sclerosis. J Dermatol Sci (2010) 0.86

Fibrosis, vascular activation, and immune abnormalities resembling systemic sclerosis in bleomycin-treated Fli-1-haploinsufficient mice. Arthritis Rheumatol (2015) 0.85

GATA-6 is a novel transcriptional repressor of the human Tenascin-C gene expression in fibroblasts. Biochim Biophys Acta (2007) 0.85

Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension. Arthritis Rheum (2013) 0.85

Anti-tumor activity of CrTX in human lung adenocarcinoma cell line A549. Acta Pharmacol Sin (2011) 0.85

Greater stress protein expression enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia. Acta Pharmacol Sin (2007) 0.85

Caveolin-1 is a negative regulator of MMP-1 gene expression in human dermal fibroblasts via inhibition of Erk1/2/Ets1 signaling pathway. J Dermatol Sci (2011) 0.84

The Protective Effects of Cobra Venom from Naja naja atra on Acute and Chronic Nephropathy. Evid Based Complement Alternat Med (2013) 0.84

Upregulation of tenascin-C expression by IL-13 in human dermal fibroblasts via the phosphoinositide 3-kinase/Akt and the protein kinase C signaling pathways. J Invest Dermatol (2006) 0.83

Crotoxin enhances the antitumor activity of gefinitib (Iressa) in SK-MES-1 human lung squamous carcinoma cells. Oncol Rep (2012) 0.83

Embelin suppresses dendritic cell functions and limits autoimmune encephalomyelitis through the TGF-β/β-catenin and STAT3 signaling pathways. Mol Neurobiol (2013) 0.83

Collagen binding alpha2beta1 and alpha1beta1 integrins play contrasting roles in regulation of Ets-1 expression in human liver myofibroblasts. Mol Cell Biochem (2006) 0.83

Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels. Arthritis Rheum (2010) 0.82

Expression of oncostatin M and its receptors in normal and cirrhotic human liver. J Hepatol (2005) 0.82

Expression of mutant N-terminal huntingtin fragment (htt552-100Q) in astrocytes suppresses the secretion of BDNF. Brain Res (2012) 0.81

Role of endoglin in fibrosis and scleroderma. Int Rev Cell Mol Biol (2012) 0.81

Combined prostaglandin E1 and lithium exert potent neuroprotection in a rat model of cerebral ischemia. Acta Pharmacol Sin (2011) 0.81

Therapeutic potential of Naja naja atra venom in a rat model of diabetic nephropathy. Biomed Environ Sci (2012) 0.81

Endothelial GATA-6 deficiency promotes pulmonary arterial hypertension. Am J Pathol (2013) 0.81

HLA-B35 and dsRNA induce endothelin-1 via activation of ATF4 in human microvascular endothelial cells. PLoS One (2013) 0.80

Fli1 is a negative regulator of estrogen receptor α in dermal fibroblasts. J Invest Dermatol (2011) 0.80

A role for estrogen receptor-α and estrogen receptor-β in collagen biosynthesis in mouse skin. J Invest Dermatol (2012) 0.80

Hypomanic symptoms assessed by the HCL-32 in patients with major depressive disorder: a multicenter trial across China. J Affect Disord (2012) 0.80

Endogenous HMGB1 is required in endotoxin tolerance. J Surg Res (2013) 0.80

Lysosomal enzyme cathepsin B is involved in kainic acid-induced excitotoxicity in rat striatum. Brain Res (2006) 0.80