Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1).

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Published in Drug Metab Dispos on August 25, 2014

Authors

Edwin J Squirewell1, Xiaoyan Qin1, Michael W Duffel2

Author Affiliations

1: Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa.
2: Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa michael-duffel@uiowa.edu.

Associated clinical trials:

Endoxifen in Adults With Hormone Receptor Positive Solid Tumors | NCT01273168

Z-Endoxifen Hydrochloride in Treating Patients With Metastatic or Locally Recurrent Estrogen Receptor-Positive Breast Cancer | NCT01327781

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