Bruton's tyrosine kinase and protein kinase C µ are required for TLR7/9-induced IKKα and IRF-1 activation and interferon-β production in conventional dendritic cells.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 4149510)

Published in PLoS One on August 29, 2014

Authors

Yan-Feng Li1, Koon-Guan Lee1, Xijun Ou1, Kong-Peng Lam2

Author Affiliations

1: Immunology Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore.
2: Immunology Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Articles cited by this

Pathogen recognition and innate immunity. Cell (2006) 44.14

A Toll-like receptor recognizes bacterial DNA. Nature (2000) 26.34

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med (1992) 22.13

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 17.57

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 16.26

IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature (2005) 13.23

Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A (2004) 9.00

IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol (2006) 7.98

Toll-like receptor signaling pathways. Science (2003) 5.86

The extended protein kinase C superfamily. Biochem J (1998) 5.84

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol (2001) 5.27

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol (2011) 3.12

Regulation of the type I IFN induction: a current view. Int Immunol (2005) 2.82

Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells. Eur J Immunol (2007) 2.62

Genetic analysis of resistance to viral infection. Nat Rev Immunol (2007) 2.47

Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement. J Exp Med (2000) 2.25

Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation. Int Immunol (2002) 2.23

Anchoring proteins for protein kinase C: a means for isozyme selectivity. FASEB J (1998) 2.20

IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature (2006) 2.16

The immunobiology of the TLR9 subfamily. Trends Immunol (2004) 2.11

Protein kinase D: a family affair. FEBS Lett (2003) 2.09

The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective. Immunol Rev (2000) 1.71

Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. Proc Natl Acad Sci U S A (2006) 1.68

Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation. J Exp Med (2000) 1.60

Role of zeta PKC in B-cell signaling and function. EMBO J (2002) 1.45

Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production. J Immunol (2006) 1.43

Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines. Blood (1995) 1.42

Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide. J Biol Chem (2005) 1.39

Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells. J Biol Chem (2009) 1.38

IkappaBalpha degradation and nuclear factor-kappaB DNA binding are insufficient for interleukin-1beta and tumor necrosis factor-alpha-induced kappaB-dependent transcription. Requirement for an additional activation pathway. J Biol Chem (1998) 1.37

Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha. J Exp Med (2002) 1.34

Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling. Proc Natl Acad Sci U S A (2006) 1.33

Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem (2007) 1.32

IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases. J Exp Med (1994) 1.30

Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3. Proc Natl Acad Sci U S A (2005) 1.28

Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response. Proc Natl Acad Sci U S A (2012) 1.22

Phorbol ester-stimulated NF-kappaB-dependent transcription: roles for isoforms of novel protein kinase C. Cell Signal (2008) 1.07

Bruton's tyrosine kinase is required for TLR-induced IL-10 production. J Immunol (2006) 1.04

Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia. Clin Immunol (2008) 1.02

Bruton's tyrosine kinase separately regulates NFkappaB p65RelA activation and cytokine interleukin (IL)-10/IL-12 production in TLR9-stimulated B Cells. J Biol Chem (2008) 1.02

Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling? Immunol Lett (2004) 0.98

PKC-alpha controls MYD88-dependent TLR/IL-1R signaling and cytokine production in mouse and human dendritic cells. Eur J Immunol (2010) 0.98

Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway. J Immunol (2009) 0.97

Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells. J Immunol (2010) 0.97

Bruton's tyrosine kinase (Btk) associates with protein kinase C mu. FEBS Lett (1999) 0.92

Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis. J Biol Chem (2007) 0.91

Protein kinase D1: a new component in TLR9 signaling. J Immunol (2008) 0.89

Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice. Immunology (2007) 0.89

Signalling of Bruton's tyrosine kinase, Btk. Scand J Immunol (1999) 0.89

Differential effects of suramin on protein kinase C isoenzymes. A novel tool for discriminating protein kinase C activities. FEBS Lett (1998) 0.87