Published in Trends Immunol on July 01, 2004
The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci U S A (2005) 4.42
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J Exp Med (2005) 3.85
Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc Natl Acad Sci U S A (2004) 2.89
Recognition of Staphylococcus aureus by the innate immune system. Clin Microbiol Rev (2005) 2.50
Toll-like receptors in neurodegeneration. Brain Res Rev (2008) 2.15
Various members of the Toll-like receptor family contribute to the innate immune response of human epidermal keratinocytes. Immunology (2005) 1.83
Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9. Springer Semin Immunopathol (2004) 1.72
Transcriptional activation of alpha/beta interferon genes: interference by nonsegmented negative-strand RNA viruses. J Virol (2005) 1.64
Involvement of the Toll-like receptor 9 signaling pathway in the induction of innate immunity by baculovirus. J Virol (2005) 1.64
Toll or toll-free adjuvant path toward the optimal vaccine development. J Clin Immunol (2007) 1.58
NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med (2007) 1.57
Evolutionary basis of codon usage and nucleotide composition bias in vertebrate DNA viruses. J Mol Evol (2006) 1.56
Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors. Trends Immunol (2009) 1.49
Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation. J Immunol (2008) 1.45
Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk. J Exp Med (2007) 1.44
DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA. EMBO J (2005) 1.44
Toll-like receptor 9 affects severity of IgA nephropathy. J Am Soc Nephrol (2008) 1.31
Differential expression of Toll-like receptors on human alveolar macrophages and autologous peripheral monocytes. Respir Res (2010) 1.22
Expression-system-dependent modulation of HIV-1 envelope glycoprotein antigenicity and immunogenicity. J Mol Biol (2010) 1.22
Toll-like receptor 9 signaling is critical for early experimental deep vein thrombosis resolution. Arterioscler Thromb Vasc Biol (2010) 1.16
Toll-like receptor 9 regulates the lung macrophage phenotype and host immunity in murine pneumonia caused by Legionella pneumophila. Infect Immun (2008) 1.14
Live Borrelia burgdorferi spirochetes elicit inflammatory mediators from human monocytes via the Toll-like receptor signaling pathway. Infect Immun (2009) 1.11
Cellular mechanisms of the adjuvant activity of the flagellin component FljB of Salmonella enterica Serovar Typhimurium to potentiate mucosal and systemic responses. Infect Immun (2005) 1.07
TLR9 signaling is required for generation of the adaptive immune protection in Cryptococcus neoformans-infected lungs. Am J Pathol (2010) 1.06
Molecular mechanisms of autoimmunity triggered by microbial infection. Arthritis Res Ther (2005) 1.05
All is not Toll: new pathways in DNA recognition. J Exp Med (2006) 1.03
Toll-like receptors in antiviral innate immunity. J Mol Biol (2013) 1.03
Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. Immunol Rev (2010) 1.02
Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9. Mediators Inflamm (2010) 1.01
TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria. Am J Trop Med Hyg (2010) 1.00
Expression and distribution of Toll-like receptors 11-13 in the brain during murine neurocysticercosis. J Neuroinflammation (2008) 0.98
Absent Toll-like receptor-9 expression predicts poor prognosis in renal cell carcinoma. J Exp Clin Cancer Res (2011) 0.98
A pilot study of pNGVL4a-CRT/E7(detox) for the treatment of patients with HPV16+ cervical intraepithelial neoplasia 2/3 (CIN2/3). Gynecol Oncol (2015) 0.98
A CpG-loaded tumor cell vaccine induces antitumor CD4+ T cells that are effective in adoptive therapy for large and established tumors. Blood (2010) 0.96
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines. Viruses (2013) 0.95
The T antigen locus of Merkel cell polyomavirus downregulates human Toll-like receptor 9 expression. J Virol (2013) 0.94
TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients. BMC Cancer (2010) 0.93
Quantitative expression of C-type lectin receptors in humans and mice. Int J Mol Sci (2012) 0.91
Molecular characterization of human plasmacytoid dendritic cells. J Clin Immunol (2009) 0.91
Toll-like receptors and skin cancer. Front Immunol (2014) 0.90
Classical versus alternative macrophage activation: the Ying and the Yang in host defense against pulmonary fungal infections. Mucosal Immunol (2014) 0.90
The linkage of innate and adaptive immune response during granulomatous development. Front Immunol (2013) 0.89
Spontaneous production of immunoglobulin M in human epithelial cancer cells. PLoS One (2012) 0.88
CpG-B oligodeoxynucleotides inhibit TLR-dependent and -independent induction of type I IFN in dendritic cells. J Immunol (2010) 0.88
Spinal interleukin-10 therapy to treat peripheral neuropathic pain. Neuromodulation (2012) 0.88
Co-ordinated regulation of plasmacytoid dendritic cell surface receptors upon stimulation with herpes simplex virus type 1. Immunology (2009) 0.87
Lymphadenopathy in a novel mouse model of Bartonella-induced cat scratch disease results from lymphocyte immigration and proliferation and is regulated by interferon-alpha/beta. Am J Pathol (2008) 0.87
Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections. J Innate Immun (2011) 0.86
TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN. Eur J Immunol (2015) 0.85
The cell biology of the innate immune response to Aspergillus fumigatus. Ann N Y Acad Sci (2012) 0.84
Innate immune responses to DNA viruses. Protein Cell (2013) 0.82
Activation of cord blood myeloid dendritic cells by Trypanosoma cruzi and parasite-specific antibodies, proliferation of CD8+ T cells, and production of IFN-γ. Med Microbiol Immunol (2011) 0.82
Expression and function of Toll-like receptor 9 in severely injured patients prone to sepsis. Clin Exp Immunol (2006) 0.81
CD36 contributes to malaria parasite-induced pro-inflammatory cytokine production and NK and T cell activation by dendritic cells. PLoS One (2013) 0.81
Controversial role of toll-like receptors in acute pancreatitis. World J Gastroenterol (2013) 0.81
TLR9-induced interferon β is associated with protection from gammaherpesvirus-induced exacerbation of lung fibrosis. Fibrogenesis Tissue Repair (2011) 0.81
DNA and its cationic lipid complexes induce CpG motif-dependent activation of murine dendritic cells. Immunology (2006) 0.80
Immunization with a MOMP-based vaccine protects mice against a pulmonary Chlamydia challenge and identifies a disconnection between infection and pathology. PLoS One (2013) 0.79
Hypoxia regulates Toll-like receptor-9 expression and invasive function in human brain cancer cells in vitro. Oncol Lett (2014) 0.79
Modulation of gene expression related to Toll-like receptor signaling in dendritic cells by poly(gamma-glutamic acid) nanoparticles. Clin Vaccine Immunol (2010) 0.79
Deciphering the function of nucleic acid sensing TLRs one regulatory step at a time. Front Biosci (Landmark Ed) (2011) 0.79
ApoE production in human monocytes and its regulation by inflammatory cytokines. PLoS One (2013) 0.79
Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice. PLoS One (2016) 0.78
Methylation Abnormalities in Mammary Carcinoma: The Methylation Suicide Hypothesis. J Cancer Ther (2014) 0.78
Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8. Proc Natl Acad Sci U S A (2016) 0.78
Correlation between TLR9 Expression and Cytokine Secretion in the Clinical Diagnosis of Systemic Lupus Erythematosus. Mediators Inflamm (2015) 0.77
Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants. BMC Immunol (2012) 0.76
Mucins and toll-like receptors: kith and kin in infection and cancer. Cancer Lett (2012) 0.76
Trypanosoma cruzi activates cord blood myeloid dendritic cells independently of cell infection. Med Microbiol Immunol (2012) 0.75
Bruton's tyrosine kinase and protein kinase C µ are required for TLR7/9-induced IKKα and IRF-1 activation and interferon-β production in conventional dendritic cells. PLoS One (2014) 0.75
DNA vaccines for prostate cancer. Pharmacol Ther (2017) 0.75
Higher Expression of Toll-like Receptors 3, 7, 8, and 9 in Pityriasis Rosea. J Pathol Transl Med (2017) 0.75