DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.

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Published in J Biol Chem on September 05, 2014

Authors

Sanjay Kumar Bharti1, Joshua A Sommers1, Jun Zhou2, Daniel L Kaplan3, Johannes N Spelbrink4, Jean-Louis Mergny2, Robert M Brosh5

Author Affiliations

1: From the Laboratory of Molecular Gerontology, NIA, National Institutes of Health, NIH Biomedical Research Center, Baltimore, Maryland 21224.
2: the ARNA Laboratory, University of Bordeaux, F-33000 Bordeaux, France, INSERM U869, Institut Européen de Chimie et Biologie (IECB), F-33600 Pessac, France.
3: the Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida 32312.
4: the FinMIT Centre of Excellence, BioMediTech and Tampere University Hospital, Pirkanmaa Hospital District, University of Tampere, FI-33014 Tampere, Finland, and the Department of Pediatrics, Nijmegan Centre for Mitochondrial Disorders, Radboud University Medical Centre, Geert Grooteplein 10, P. O. Box 9101, 6500 HB Nijmegen, The Netherlands.
5: From the Laboratory of Molecular Gerontology, NIA, National Institutes of Health, NIH Biomedical Research Center, Baltimore, Maryland 21224, broshr@mail.nih.gov.

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