Published in Pain on September 06, 2014
Orthopedic surgery and bone fracture pain are both significantly attenuated by sustained blockade of nerve growth factor. Pain (2015) 0.87
Sclerostin Immunoreactivity Increases in Cortical Bone Osteocytes and Decreases in Articular Cartilage Chondrocytes in Aging Mice. J Histochem Cytochem (2015) 0.78
Ethical guidelines for investigations of experimental pain in conscious animals. Pain (1983) 17.70
Burden of major musculoskeletal conditions. Bull World Health Organ (2003) 10.89
Astroglia induce neurogenesis from adult neural stem cells. Nature (2002) 6.41
Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects. CMAJ (2006) 6.12
Systematic review: opioid treatment for chronic back pain: prevalence, efficacy, and association with addiction. Ann Intern Med (2007) 5.68
Opioids in chronic non-cancer pain: systematic review of efficacy and safety. Pain (2004) 5.51
Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem (2003) 4.34
Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron (2005) 3.54
Peak bone mass. Osteoporos Int (2000) 3.49
The incidence of complex regional pain syndrome: a population-based study. Pain (2006) 3.20
Pathologic alterations of cutaneous innervation and vasculature in affected limbs from patients with complex regional pain syndrome. Pain (2006) 3.20
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol Pain (2007) 2.91
The impact of post-operative pain on outcomes following hip fracture. Pain (2003) 2.66
The burden of musculoskeletal disease--a global perspective. Clin Rheumatol (2006) 2.59
Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur. Neuroscience (2002) 2.57
Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord. Nat Med (2000) 2.54
Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet (1997) 2.52
Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature (1988) 2.47
Complex regional pain syndrome type I: incidence and prevalence in Olmsted county, a population-based study. Pain (2003) 2.44
Efficacy of opioids for chronic pain: a review of the evidence. Clin J Pain (2008) 2.38
The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain. Rheumatology (Oxford) (2008) 2.28
5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. J Neurosci (2009) 2.21
Musculoskeletal pain in the obese: a comparison with a general population and long-term changes after conventional and surgical obesity treatment. Pain (2003) 2.03
TRP channels: targets for the relief of pain. Biochim Biophys Acta (2007) 1.99
Mast cells synthesize, store, and release nerve growth factor. Proc Natl Acad Sci U S A (1994) 1.97
Variability in the assessment of fracture-healing in orthopaedic trauma studies. J Bone Joint Surg Am (2008) 1.97
Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species. J Neurosci (1984) 1.88
Gabapentin normalizes spinal neuronal responses that correlate with behavior in a rat model of cancer-induced bone pain. Anesthesiology (2005) 1.80
Complex regional pain syndrome: mystery explained? Lancet Neurol (2003) 1.75
Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis. Ann Rheum Dis (2007) 1.73
Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages. Proc Natl Acad Sci U S A (1987) 1.70
Opioid therapy for chronic pain in the United States: promises and perils. Pain (2013) 1.69
Innervation of "painful" lumbar discs. Spine (Phila Pa 1976) (1997) 1.58
Peptides and the primary afferent nociceptor. J Neurosci (1993) 1.58
A lack of consensus in the assessment of fracture healing among orthopaedic surgeons. J Orthop Trauma (2002) 1.56
Gabapentin for acute and chronic pain. Cochrane Database Syst Rev (2005) 1.55
Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain. Exp Neurol (2005) 1.51
Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells. Spine (Phila Pa 1976) (2007) 1.39
The early fracture hematoma and its potential role in fracture healing. Tissue Eng Part B Rev (2010) 1.38
Hyperphosphorylated neurofilament NF-H is a serum biomarker of axonal injury. Biochem Biophys Res Commun (2005) 1.36
A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain. Bone (2009) 1.31
Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain. Neuroscience (2010) 1.31
Adverse effects of chronic opioid therapy for chronic musculoskeletal pain. Nat Rev Rheumatol (2010) 1.29
Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism. Mol Ther (2008) 1.28
A systematic review of randomized trials of long-term opioid management for chronic non-cancer pain. Pain Physician (2011) 1.26
Characterization of a closed femur fracture model in mice. J Orthop Trauma (2004) 1.25
Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain. J Neurosci (2010) 1.24
Mechanisms of chronic pain in osteoarthritis. Curr Rheumatol Rep (2012) 1.22
Outcome assessment in clinical trials of fracture-healing. J Bone Joint Surg Am (2008) 1.19
A role for Piezo2 in EPAC1-dependent mechanical allodynia. Nat Commun (2013) 1.19
Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors. Physiol Rev (2012) 1.17
The majority of myelinated and unmyelinated sensory nerve fibers that innervate bone express the tropomyosin receptor kinase A. Neuroscience (2011) 1.16
Different tumors in bone each give rise to a distinct pattern of skeletal destruction, bone cancer-related pain behaviors and neurochemical changes in the central nervous system. Int J Cancer (2003) 1.15
Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus. Dev Biol (2010) 1.11
Site-specific CGRP innervation coincides with bone formation during fracture healing and modeling: A study in rat angulated tibia. J Orthop Res (2007) 1.10
Rapid proliferation of calcitonin gene-related peptide-immunoreactive nerves during healing of rat tibial fracture suggests neural involvement in bone growth and remodelling. Neuroscience (1993) 1.09
Musculoskeletal pain in obese children and adolescents. Acta Paediatr (2008) 1.09
Existence of a neuropathic pain component in patients with osteoarthritis of the knee. Yonsei Med J (2012) 1.08
Human intervertebral disc aggrecan inhibits nerve growth in vitro. Arthritis Rheum (2002) 1.07
Organization of a unique net-like meshwork of CGRP+ sensory fibers in the mouse periosteum: implications for the generation and maintenance of bone fracture pain. Neurosci Lett (2007) 1.07
Breast cancer-induced bone remodeling, skeletal pain, and sprouting of sensory nerve fibers. J Pain (2011) 1.06
Peripheral patterns of calcitonin-gene-related peptide general somatic sensory innervation: cutaneous and deep terminations. J Comp Neurol (1989) 1.06
An improved behavioural assay demonstrates that ultrasound vocalizations constitute a reliable indicator of chronic cancer pain and neuropathic pain. Mol Pain (2010) 1.05
Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain. Mol Pain (2010) 1.03
Delayed reinnervation by nonpeptidergic nociceptive afferents of the glabrous skin of the rat hindpaw in a neuropathic pain model. J Comp Neurol (2011) 1.01
Capsaicin-sensitive sensory nerve fibers contribute to the generation and maintenance of skeletal fracture pain. Neuroscience (2009) 1.00
Influence of diclofenac (group of nonsteroidal anti-inflammatory drugs) on fracture healing. Arch Orthop Trauma Surg (2003) 0.98
An immunocytochemical study of cutaneous innervation and the distribution of neuropeptides and protein gene product 9.5 in man and commonly employed laboratory animals. Am J Anat (1991) 0.98
Expression of semaphorin 3A and its receptors in the human intervertebral disc: potential role in regulating neural ingrowth in the degenerate intervertebral disc. Arthritis Res Ther (2010) 0.97
Heterogeneity of antigen expression explains controversy over glomerular macrophage accumulation in mouse glomerulonephritis. Nephrol Dial Transplant (2003) 0.96
Risk factors for continued opioid use one to two months after surgery for musculoskeletal trauma. J Bone Joint Surg Am (2014) 0.96
Human intervertebral disc cells promote nerve growth over substrata of human intervertebral disc aggrecan. Spine (Phila Pa 1976) (2006) 0.95
Painful, degenerating intervertebral discs up-regulate neurite sprouting and CGRP through nociceptive factors. J Cell Mol Med (2014) 0.95
Calcitonin gene-related peptide, substance P and GAP-43/B-50 immunoreactivity in the normal and arthrotic knee joint of the mouse. Histochemistry (1992) 0.95
Gabapentin in postamputation phantom limb pain: a randomized, double-blind, placebo-controlled, cross-over study. Reg Anesth Pain Med (2002) 0.94
The effect of aging on the density of the sensory nerve fiber innervation of bone and acute skeletal pain. Neurobiol Aging (2010) 0.93
Involvement of sensory nerves and immune cells in osteophyte formation in the ankle joint of adjuvant arthritic rats. Histochem Cell Biol (2002) 0.92
Nonsteroidal anti-inflammatory drug-associated toxicity of the liver, lower gastrointestinal tract, and esophagus. Am J Med (1998) 0.91
Immunohistochemical detection of human skin nerve fibers. Acta Histochem (1997) 0.91
Distribution of P2X(3)-immunoreactive fibers in hairy and glabrous skin of the rat. J Comp Neurol (2009) 0.91
Type of sensory nerve fibre sprouting to form a neuroma. Nature (1976) 0.90
Osteoporosis and the global competition for health care resources. J Bone Miner Res (2004) 0.89
Norepinephrine-induced nerve growth factor depletion causes cardiac sympathetic denervation in severe heart failure. Auton Neurosci (2010) 0.89
Changes resembling complex regional pain syndrome following surgery and immobilization. J Pain (2013) 0.89
Pathophysiology of bone pain: a review. Acta Orthop Scand (2001) 0.88
Sensory and sympathetic nerve fibers undergo sprouting and neuroma formation in the painful arthritic joint of geriatric mice. Arthritis Res Ther (2012) 0.87
The physiology of pain mechanisms: from the periphery to the brain. Rheum Dis Clin North Am (2008) 0.87
Nerve growth factor and associated nerve sprouting contribute to local mechanical hyperalgesia in a rat model of bone injury. Eur J Pain (2011) 0.86
Distribution of nerve endings and sensory neuropeptides in rat synovium, meniscus and bone. Int J Tissue React (1992) 0.86
Outcomes assessment in fracture healing trials: a primer. J Orthop Trauma (2010) 0.86
Orthopedic aspects of familial insensitivity to pain due to a novel nerve growth factor beta mutation. Acta Orthop (2006) 0.86
Bone reinnervation after fracture: a study in the rat. J Bone Miner Res (2001) 0.85
Characteristics of sensory DRG neurons innervating the wrist joint in rats. Eur J Pain (2006) 0.84
Aberrant peripheral nerves and microneuromas in otherwise normal medullas. J Neuropathol Exp Neurol (1983) 0.84
Role of bradykinin in the vascular permeability response induced by carrageenin in rats. Br J Pharmacol (1988) 0.82
Co-existence of tyrosine hydroxylase and dopamine beta-hydroxylase immunoreactivity in glomus cells of the cat carotid body. J Auton Nerv Syst (1991) 0.82
Nociceptive phenotype of dorsal root ganglia neurons innervating the subchondral bone in rat knee joints. Eur J Pain (2013) 0.80
Measurement of prostaglandin E2 in an inflammatory exudate: effects of nonsteroidal anti-inflammatory agents. J Pharmacol Exp Ther (1977) 0.80
Norrbottnian congenital insensitivity to pain. Acta Orthop Suppl (2006) 0.80
Rethinking the role of opioids in the outpatient management of chronic nonmalignant pain. Curr Med Res Opin (2014) 0.79