Published in EMBO J on September 08, 2014
SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes. J Cell Biol (2016) 0.89
Cellular processes associated with LRRK2 function and dysfunction. FEBS J (2015) 0.86
Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression. Hum Mol Genet (2015) 0.82
Editorial: Golgi Pathology in Neurodegenerative Diseases. Front Neurosci (2016) 0.81
Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease. Front Neurosci (2015) 0.80
LRRK2 Regulates Voltage-Gated Calcium Channel Function. Front Mol Neurosci (2016) 0.79
Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease. FEBS Lett (2015) 0.78
LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand? Curr Neuropharmacol (2016) 0.76
LRRK2 at the interface of autophagosomes, endosomes and lysosomes. Mol Neurodegener (2016) 0.76
Sec16 alternative splicing dynamically controls COPII transport efficiency. Nat Commun (2016) 0.76
LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways. Hum Mol Genet (2016) 0.75
Sec16A is critical for both conventional and unconventional secretion of CFTR. Sci Rep (2017) 0.75
mGluR long-term depression regulates GluA2 association with COPII vesicles and exit from the endoplasmic reticulum. EMBO J (2016) 0.75
Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways. Cell Syst (2017) 0.75
LRRK2 directing ER-to-Golgi transport? (ER)yES! EMBO J (2014) 0.75
DGKδ triggers endoplasmic reticulum release of IFT88-containing vesicles destined for the assembly of primary cilia. Sci Rep (2017) 0.75
Golgi ribbon disassembly during mitosis, differentiation and disease progression. Curr Opin Cell Biol (2017) 0.75
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron (2004) 14.35
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron (2004) 13.99
Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet (2009) 10.34
ER-to-Golgi transport visualized in living cells. Nature (1997) 10.24
Genomewide association study of leprosy. N Engl J Med (2009) 8.17
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat Genet (2009) 8.11
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science (2006) 7.72
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci U S A (2005) 6.98
Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nat Neurosci (2006) 5.32
Visualization of ER-to-Golgi transport in living cells reveals a sequential mode of action for COPII and COPI. Cell (1997) 5.13
RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. Neuron (2013) 4.67
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci (2001) 4.54
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. Biochem J (2007) 3.89
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J Neurochem (2008) 3.86
Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann Neurol (2006) 3.72
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol (2010) 3.68
Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. Neuron (2009) 3.54
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J (2008) 3.51
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci U S A (2007) 3.39
Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron (2009) 3.15
Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins. Oncogene (1990) 2.89
Organelles and trafficking machinery for postsynaptic plasticity. Annu Rev Neurosci (2006) 2.82
NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms. Trends Neurosci (1993) 2.76
Syntaxin 6 functions in trans-Golgi network vesicle trafficking. Mol Biol Cell (1997) 2.70
Dynamics of transitional endoplasmic reticulum sites in vertebrate cells. Mol Biol Cell (2000) 2.64
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science (2013) 2.61
Activity regulates the synaptic localization of the NMDA receptor in hippocampal neurons. Neuron (1997) 2.59
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum Mol Genet (2009) 2.55
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Neuron (2012) 2.49
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat Immunol (2011) 2.42
Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. J Neurochem (2007) 2.40
Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. J Neurosci (2009) 2.36
COPII and the regulation of protein sorting in mammals. Nat Cell Biol (2011) 2.33
R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. Proc Natl Acad Sci U S A (2009) 2.28
The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity. Exp Cell Res (2007) 2.27
The ER-Golgi intermediate compartment (ERGIC): in search of its identity and function. J Cell Sci (2006) 2.21
Activity-dependent mRNA splicing controls ER export and synaptic delivery of NMDA receptors. Neuron (2003) 2.09
Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p. J Cell Biol (1995) 1.95
Interplay of LRRK2 with chaperone-mediated autophagy. Nat Neurosci (2013) 1.88
Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization. Mol Biol Cell (2006) 1.77
Coupling of ER exit to microtubules through direct interaction of COPII with dynactin. Nat Cell Biol (2004) 1.76
Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells. Traffic (2006) 1.65
Leucine-rich repeat kinase 2 associates with lipid rafts. Hum Mol Genet (2007) 1.65
Sec16 is a determinant of transitional ER organization. Curr Biol (2005) 1.64
Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER. J Cell Sci (2009) 1.56
The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules. J Neurosci Res (2008) 1.54
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. Proc Natl Acad Sci U S A (2014) 1.53
Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning. Hum Mol Genet (2011) 1.49
Clinical and pathologic features of families with LRRK2-associated Parkinson's disease. J Neural Transm Suppl (2006) 1.46
Subcellular dynamics of type II PKA in neurons. Neuron (2009) 1.43
SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway. Nat Neurosci (2009) 1.40
Regulation of coat assembly--sorting things out at the ER. Curr Opin Cell Biol (2010) 1.33
Secretory trafficking in neuronal dendrites. Nat Cell Biol (2004) 1.32
Endoplasmic reticulum export site formation and function in dendrites. J Neurosci (2004) 1.28
cAMP-dependent protein kinase mediates activity-regulated synaptic targeting of NMDA receptors. J Neurosci (2001) 1.26
LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity. Nat Neurosci (2014) 1.24
Structure of the Sec13-Sec16 edge element, a template for assembly of the COPII vesicle coat. J Cell Biol (2010) 1.20
ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association. EMBO J (2011) 1.13
The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation. Biochem J (2012) 1.11
MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein. Hum Mol Genet (2012) 1.11
Insights into structural and regulatory roles of Sec16 in COPII vesicle formation at ER exit sites. Mol Biol Cell (2012) 1.09
The endoplasmic reticulum and protein trafficking in dendrites and axons. Trends Cell Biol (2011) 1.08
A possible role for stable microtubules in intracellular transport from the endoplasmic reticulum to the Golgi apparatus. J Cell Sci (1994) 1.07
LRRK2 function on actin and microtubule dynamics in Parkinson disease. Commun Integr Biol (2010) 1.04
Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5. Exp Neurobiol (2010) 0.98
A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation. J Biol Chem (2013) 0.97
LRRK2 mutations are a common cause of Parkinson's disease in Spain. Eur J Neurol (2006) 0.92
LRRK2 expression is enriched in the striosomal compartment of mouse striatum. Neurobiol Dis (2012) 0.90
Impaired neurotransmitter release in Alzheimer's and Parkinson's diseases. Neurodegener Dis (2010) 0.90
Characterization of human Sec16B: indications of specialized, non-redundant functions. Sci Rep (2011) 0.81
The pleomorphic pathology of inherited Parkinson's disease: lessons from LRRK2. Curr Neurol Neurosci Rep (2006) 0.78