Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries.

PubWeight™: 0.85‹?›

🔗 View Article (PMC 4161349)

Published in PLoS One on September 11, 2014

Authors

Olivier Barré1, Antoine Dufour1, Ulrich Eckhard1, Reinhild Kappelhoff1, François Béliveau2, Richard Leduc2, Christopher M Overall3

Author Affiliations

1: Centre for Blood Research, Department of Oral Biological & Medical Sciences, University of British Columbia, Vancouver, BC, Canada.
2: Department of Pharmacology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
3: Centre for Blood Research, Department of Oral Biological & Medical Sciences, University of British Columbia, Vancouver, BC, Canada; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.

Articles cited by this

Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis (1999) 45.01

Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. Anal Chem (2002) 35.30

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Bioinformatics (2005) 34.83

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Mol Syst Biol (2011) 28.61

TANDEM: matching proteins with tandem mass spectra. Bioinformatics (2004) 17.41

Delineation of prognostic biomarkers in prostate cancer. Nature (2001) 12.25

UniProt Knowledgebase: a hub of integrated protein data. Database (Oxford) (2011) 11.43

ESPript/ENDscript: Extracting and rendering sequence and 3D information from atomic structures of proteins. Nucleic Acids Res (2003) 8.66

Protein structure homology modeling using SWISS-MODEL workspace. Nat Protoc (2009) 5.42

A guided tour of the Trans-Proteomic Pipeline. Proteomics (2010) 5.09

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment. EMBO J (1989) 4.49

The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab (2008) 3.78

The serine protease TMPRSS6 is required to sense iron deficiency. Science (2008) 3.70

Improved visualization of protein consensus sequences by iceLogo. Nat Methods (2009) 3.64

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Res (2013) 3.28

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. II. Crystallographic refinement at 1.9 A resolution. J Mol Biol (1974) 3.17

Protease degradomics: a new challenge for proteomics. Nat Rev Mol Cell Biol (2002) 3.17

Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites. Nat Biotechnol (2008) 3.07

iProphet: multi-level integrative analysis of shotgun proteomic data improves peptide and protein identification rates and error estimates. Mol Cell Proteomics (2011) 2.88

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis. Blood (2008) 2.75

Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis. Oncogene (2002) 2.74

Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes. J Biol Chem (2001) 2.56

The case for open-source software in drug discovery. Drug Discov Today (2005) 2.49

Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease. J Biol Chem (2000) 2.47

Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites. Mol Biotechnol (2002) 2.40

Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer. Cancer Metastasis Rev (2003) 2.39

In search of partners: linking extracellular proteases to substrates. Nat Rev Mol Cell Biol (2007) 2.37

Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins. J Biol Chem (2002) 2.31

TopDraw: a sketchpad for protein structure topology cartoons. Bioinformatics (2003) 2.27

Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation. J Biol Chem (2006) 2.07

Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics. Biochim Biophys Acta (2009) 2.04

Sub-angstrom modeling of complexes between flexible peptides and globular proteins. Proteins (2010) 1.89

A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells. Biochemistry (1988) 1.89

Rosetta FlexPepDock web server--high resolution modeling of peptide-protein interactions. Nucleic Acids Res (2011) 1.85

Hypertension in mice lacking the proatrial natriuretic peptide convertase corin. Proc Natl Acad Sci U S A (2005) 1.84

Adhesion signaling by a novel mitotic substrate of src kinases. Oncogene (2005) 1.68

FFAS server: novel features and applications. Nucleic Acids Res (2011) 1.52

Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers. Biochem J (2005) 1.51

Type II transmembrane serine proteases in development and disease. Int J Biochem Cell Biol (2007) 1.45

Matriptase and its putative role in cancer. Cell Mol Life Sci (2006) 1.44

Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains. Proc Natl Acad Sci U S A (1994) 1.31

A role for membrane-type serine protease (MT-SP1) in intestinal epithelial turnover. Biochem Biophys Res Commun (2001) 1.28

Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis. Haematologica (2009) 1.27

Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase. J Biol Chem (2001) 1.27

Ectodomain shedding and autocleavage of the cardiac membrane protease corin. J Biol Chem (2011) 1.27

Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes. J Biol Chem (2002) 1.21

Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. Mol Cell Proteomics (2011) 1.20

Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides. FEBS J (2009) 1.17

Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression. J Biol Chem (2008) 1.14

Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity. Biochem J (2005) 1.13

Localization of the mosaic transmembrane serine protease corin to heart myocytes. Eur J Biochem (2000) 1.13

Cloning and characterization of the cDNA for human airway trypsin-like protease. J Biol Chem (1998) 1.12

Purification, characterization, and localization of a novel trypsin-like protease found in the human airway. Am J Respir Cell Mol Biol (1997) 1.12

Matriptase-dependent cell surface proteolysis in epithelial development and pathogenesis. Front Biosci (2007) 1.10

Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation. J Biol Chem (1995) 1.09

Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression. J Biol Chem (2010) 1.08

Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry. Nat Protoc (2011) 1.04

Biochemical characterization and N-terminomics analysis of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine and vimentin cleavages enhance cell migration and macrophage phagocytic activities. J Biol Chem (2012) 1.04

Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. Proc Natl Acad Sci U S A (2003) 1.04

Pro-urokinase-type plasminogen activator is a substrate for hepsin. J Biol Chem (2006) 1.03

Matriptase activates stromelysin (MMP-3) and promotes tumor growth and angiogenesis. Cancer Sci (2006) 1.03

Proteolytic processing of the serine protease matriptase-2: identification of the cleavage sites required for its autocatalytic release from the cell surface. Biochem J (2010) 0.99

Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites. Biol Chem (2011) 0.96

Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT. PLoS One (2011) 0.96

MT-SP1 proteolysis and regulation of cell-microenvironment interactions. Front Biosci (2008) 0.96

Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes. J Biol Chem (2004) 0.96

The human airway trypsin-like protease modulates the urokinase receptor (uPAR, CD87) structure and functions. Am J Physiol Lung Cell Mol Physiol (2007) 0.95

FFAS-3D: improving fold recognition by including optimized structural features and template re-ranking. Bioinformatics (2013) 0.92

Analysis of the degradome with the CLIP-CHIP microarray. Methods Mol Biol (2010) 0.92

Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen. J Proteomics (2013) 0.92

Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25). FEBS J (2006) 0.88

Family-wide characterization of matrix metalloproteinases from Arabidopsis thaliana reveals their distinct proteolytic activity and cleavage site specificity. Biochem J (2014) 0.87

Differential expression of a novel serine protease homologue in squamous cell carcinoma of the head and neck. Br J Cancer (2001) 0.86

Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1. BMC Struct Biol (2011) 0.84

Substrate specificity and inhibitory study of human airway trypsin-like protease. Bioorg Med Chem (2010) 0.83

Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family. FEBS J (2007) 0.80

Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA). J Mol Biol (2004) 0.79

The CLIP-CHIP oligonucleotide microarray: dedicated array for analysis of all protease, nonproteolytic homolog, and inhibitor gene transcripts in human and mouse. Curr Protoc Protein Sci (2009) 0.76