Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial.

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Published in Lancet Oncol on September 18, 2014

Authors

Jesús F San-Miguel1, Vânia T M Hungria2, Sung-Soo Yoon3, Meral Beksac4, Meletios Athanasios Dimopoulos5, Ashraf Elghandour6, Wieslaw Wiktor Jedrzejczak7, Andreas Günther8, Thanyaphong Na Nakorn9, Noppadol Siritanaratkul10, Paolo Corradini11, Suporn Chuncharunee12, Je-Jung Lee13, Robert L Schlossman14, Tatiana Shelekhova15, Kwee Yong16, Daryl Tan17, Tontanai Numbenjapon18, Jamie D Cavenagh19, Jian Hou20, Richard LeBlanc21, Hareth Nahi22, Lugui Qiu23, Hans Salwender24, Stefano Pulini25, Philippe Moreau26, Krzysztof Warzocha27, Darrell White28, Joan Bladé29, WenMing Chen30, Javier de la Rubia31, Peter Gimsing32, Sagar Lonial33, Jonathan L Kaufman33, Enrique M Ocio34, Ljupco Veskovski35, Sang Kyun Sohn36, Ming-Chung Wang37, Jae Hoon Lee38, Hermann Einsele39, Monika Sopala40, Claudia Corrado40, Bourras-Rezki Bengoudifa40, Florence Binlich41, Paul G Richardson14

Author Affiliations

1: Clínica Universidad de Navarra-CIMA, Pamplona, Spain. Electronic address: sanmiguel@unav.es.
2: Santa Casa de Misericordia de São Paulo Hospital, São Paulo, Brazil.
3: Seoul National University Hospital, Seoul, South Korea.
4: Ankara University School of Medicine, Ankara, Turkey.
5: University of Athens School of Medicine, Athens, Greece.
6: Alexandria University, Alexandria, Egypt.
7: Medical University of Warsaw, Warsaw, Poland.
8: University of Kiel, Kiel, Germany.
9: Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
10: Siriraj Hospital, Bangkok, Thailand.
11: Fondazione IRCCS Istituto Nazionale dei Tumori, University of Milan, Milan, Italy.
12: Ramathibodi Hospital, Bangkok, Thailand.
13: Chonnam National University Hwasun Hospital, Hwasun, South Korea.
14: Dana-Farber Cancer Institute, Boston, MA, USA.
15: Clinic of Professional Pathology and Haematology, Saratov State Medical University, Saratov, Russia.
16: UCL Cancer Institute, University College London, London, UK.
17: Singapore General Hospital, Singapore.
18: Phramongkutklao Hospital, Bangkok, Thailand.
19: St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
20: Chang Zheng Hospital, Shanghai, China.
21: Maisonneuve-Rosemont Hospital and University of Montreal, Montreal, QC, Canada.
22: Karolinska University Hospital, Stockholm, Sweden.
23: State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
24: Asklepios Clinic Altona, Hamburg, Germany.
25: Spirito Santo Hospital, Pescara, Italy.
26: Nantes University Hospital, Nantes, France.
27: Institute of Haematology and Transfusion Medicine, Warsaw, Poland.
28: Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada.
29: Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
30: Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
31: University Hospital La Fe and Universidad Católica San Vicente Mártir, Valencia, Spain.
32: Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.
33: Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
34: University Hospital and Cancer Research Center, University of Salamanca-Instituto de Investigación Biomédica de Salamanca, Instituto de Biología Molecular y Celular del Cáncer, Salamanca, Spain.
35: Sahlgrenska University Hospital, Göteborg, Sweden.
36: Kyungpook National University, Daegu, South Korea.
37: Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
38: Gachon University Gil Medical Center, Incheon, South Korea.
39: University Hospital Würzburg, Würzburg, Germany.
40: Novartis Pharma AG, Basel, Switzerland.
41: Novartis Pharma SAS, Rueil-Malmaison, France.

Associated clinical trials:

Panobinostat or Placebo With Bortezomib and Dexamethasone in Patients With Relapsed Multiple Myeloma (PANORAMA-1) | NCT01023308

Carfilzomib, Iberdomide (CC-220) and Dexamethasone (KID) in Transplant Eligible Multiple Myeloma | NCT05199311

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