Epigenetic Therapeutics: A New Weapon in the War Against Cancer.

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🔗 View Article (PMID 26768237)

Published in Annu Rev Med on January 14, 2016

Authors

Nita Ahuja1, Anup R Sharma1, Stephen B Baylin1

Author Affiliations

1: Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287; email: sbaylin@jhmi.edu.

Associated clinical trials:

Panobinostat or Placebo With Bortezomib and Dexamethasone in Patients With Relapsed Multiple Myeloma (PANORAMA-1) | NCT01023308

A Survival Study in Patients With High Risk Myelodysplastic Syndromes Comparing Azacitidine Versus Conventional Care | NCT00071799

Azacitidine and Entinostat in Treating Patients With Advanced Breast Cancer | NCT01349959

First-Line Gemcitabine, Cisplatin + Ipilimumab for Metastatic Urothelial Carcinoma | NCT01524991

Depsipeptide to Treat Patients With Cutaneous T-Cell Lymphoma and Peripheral T-Cell Lymphoma | NCT00007345

A Phase 2 Multi-Center Study of Entinostat (SNDX-275) in Patient With Relapsed or Refractory Hodgkin's Lymphoma | NCT00866333

A Phase III Randomized, Double Blind, Placebo Controlled Multi-center Study of Panobinostat for Maintenance of Response in Patients With Hodgkin's Lymphoma (HL) (PATH) | NCT01034163

Study of MDX-010 in Patients With Metastatic Hormone-Refractory Prostate Cancer | NCT00323882

A Study of SB939 in Patients With Translocation-Associated Recurrent/Metastatic Sarcomas (IND200) | NCT01112384

Azacitidine and Entinostat in Treating Patients With Recurrent Advanced Non-Small Cell Lung Cancer | NCT00387465

Phase II Study for Previously Untreated Subjects With Non Small Cell Lung Cancer (NSCLC) or Small Cell Lung Cancer (SCLC) | NCT00527735

Exemestane With or Without Entinostat in Treating Patients With Recurrent Hormone Receptor-Positive Breast Cancer That is Locally Advanced or Metastatic | NCT02115282

Oral SAHA (Suberoylanilide Hydroxamic Acid) in Advanced Cutaneous T-cell Lymphoma (0683-001) | NCT00091559

A Phase II Clinical Trial of PXD101 in Patients With Recurrent or Refractory Cutaneous and Peripheral T-Cell Lymphomas (PXD101-CLN-6) | NCT00274651

Azacitidine and Entinostat in Treating Patients With Metastatic Colorectal Cancer | NCT01105377

Entinostat in Combination With Aldesleukin in Treating Patients With Metastatic Kidney Cancer | NCT01038778

Safety and Efficacy Study of Pracinostat With Azacitadine in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia (AML) | NCT01912274

Trial of Decitabine as a Sensitizer to Carboplatin in Platinum Resistant Recurrent Ovarian Cancer | NCT00477386

Study of Oral LBH589 in Adult Patients With Refractory Cutaneous T-Cell Lymphoma | NCT00425555

Long-term Study Evaluating the Effect of Givinostat in Patients With Chronic Myeloproliferative Neoplasms | NCT01761968

SGI-110 in Adults With Untreated Acute Myeloid Leukemia (AML), Not Considered Candidates for Intensive Remission Induction | NCT02348489

Maximum Tolerated Dose Study of Belinostat (PXD-101)in Combination With Paclitaxel Plus Carboplatin in Chemotherapy-Naive Patients With Stage IV Non-Small-Cell Lung Cancer (NSCLC) | NCT01310244

Phase 2 Study of Pracinostat With Azacitidine in Patients With Previously Untreated Myelodysplastic Syndrome | NCT01873703

PXD101 in Treating Patients With Acute Myeloid Leukemia | NCT00357032

Vorinostat and Decitabine in Treating Patients With Advanced Solid Tumors or Relapsed or Refractory Non-Hodgkin's Lymphoma, Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, or Chronic Myelogenous Leukemia | NCT00275080

Study of Valproic Acid (VPA) vs Placebo to Shorten Time of Indwelling Pleural Catheter | NCT01900730

Belinostat in Treating Patients With Advanced Ovarian Epithelial Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer or Ovarian Low Malignant Potential Tumors | NCT00301756

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