Stromal-dependent tumor promotion by MIF family members.

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Published in Cell Signal on September 30, 2014

Authors

Robert A Mitchell1, Kavitha Yaddanapudi2

Author Affiliations

1: JG Brown Cancer Center, Department of Medicine, University of Louisville, Louisville, KY 40202, United States. Electronic address: robert.mitchell@louisville.edu.
2: JG Brown Cancer Center, Department of Medicine, University of Louisville, Louisville, KY 40202, United States.

Associated clinical trials:

NCT00618891

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NK cell recognition. Annu Rev Immunol (2005) 14.40

Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell (2006) 13.79

Macrophage diversity enhances tumor progression and metastasis. Cell (2010) 13.41

Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science (1966) 13.12

Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. Proc Natl Acad Sci U S A (1966) 12.29

In search of the 'missing self': MHC molecules and NK cell recognition. Immunol Today (1990) 10.84

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature (1996) 10.14

Functions of natural killer cells. Nat Immunol (2008) 9.88

Distinct role of macrophages in different tumor microenvironments. Cancer Res (2006) 9.29

Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J Immunol (2008) 9.25

Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol (2007) 8.31

The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J Pathol (2002) 8.27

Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med (1985) 8.21

Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J Immunol (2001) 7.43

Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol (2001) 7.07

Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc Natl Acad Sci U S A (2002) 6.98

Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. Cancer Res (2005) 6.66

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest (2006) 6.61

Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol Immunother (2008) 6.55

Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest (2007) 6.31

Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nat Med (2007) 5.65

Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer (2006) 5.60

MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med (2007) 5.28

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Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A (2010) 4.97

MIF signal transduction initiated by binding to CD74. J Exp Med (2003) 4.79

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The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem (2007) 4.22

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Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. J Immunol (1998) 3.98

Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin Cancer Res (2000) 3.86

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An essential regulatory role for macrophage migration inhibitory factor in T-cell activation. Proc Natl Acad Sci U S A (1996) 3.79

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Identification of four subsets of human CD3-CD16+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition. J Exp Med (1990) 3.63

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The macrophage colony-stimulating factor 1 response signature in breast carcinoma. Clin Cancer Res (2009) 2.00

Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor. Proc Natl Acad Sci U S A (1996) 1.95

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Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer. Cancer Res (2002) 1.68

2011: the immune hallmarks of cancer. Cancer Immunol Immunother (2011) 1.66