Published in Genes Dev on October 15, 2013
Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal (2014) 2.42
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Nat Commun (2014) 1.95
EMT, CTCs and CSCs in tumor relapse and drug-resistance. Oncotarget (2015) 1.92
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13. Breast Cancer Res (2014) 1.41
ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance. Cell Cycle (2015) 1.30
The long non-coding RNA HNF1A-AS1 regulates proliferation and metastasis in lung adenocarcinoma. Oncotarget (2015) 1.27
TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis. J Oncol (2015) 1.23
Cellular and metabolic functions for autophagy in cancer cells. Trends Cell Biol (2014) 1.16
Role of epithelial-mesenchymal transition in gastric cancer initiation and progression. World J Gastroenterol (2014) 1.06
Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer Cells. Front Oncol (2015) 1.05
Towards elucidating the connection between epithelial-mesenchymal transitions and stemness. J R Soc Interface (2014) 1.04
YB-1 expression promotes epithelial-to-mesenchymal transition in prostate cancer that is inhibited by a small molecule fisetin. Oncotarget (2014) 1.02
Epithelial-mesenchymal plasticity of breast cancer stem cells: implications for metastasis and therapeutic resistance. Curr Pharm Des (2015) 1.01
The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers. Oncogene (2015) 1.01
Cripto-1 as a novel therapeutic target for triple negative breast cancer. Oncotarget (2015) 1.01
Metastatic tumors to the jaws and mouth. Head Neck Pathol (2014) 1.00
Epithelial to Mesenchymal Transition in a Clinical Perspective. J Oncol (2015) 0.99
A role for partial endothelial-mesenchymal transitions in angiogenesis? Arterioscler Thromb Vasc Biol (2014) 0.97
SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma. Oncogene (2015) 0.95
MicroRNA-940 suppresses prostate cancer migration and invasion by regulating MIEN1. Mol Cancer (2014) 0.95
Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis. Genes Dev (2015) 0.95
The biological and clinical importance of epithelial-mesenchymal transition in circulating tumor cells. J Cancer Res Clin Oncol (2014) 0.94
Sweet and sour: the impact of differential glycosylation in cancer cells undergoing epithelial-mesenchymal transition. Front Oncol (2014) 0.92
ID1 promotes breast cancer metastasis by S100A9 regulation. Mol Cancer Res (2014) 0.92
Overexpression of Nodal induces a metastatic phenotype in pancreatic cancer cells via the Smad2/3 pathway. Oncotarget (2015) 0.92
Illuminating breast cancer invasion: diverse roles for cell-cell interactions. Curr Opin Cell Biol (2014) 0.91
Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway. Drug Des Devel Ther (2015) 0.90
The role of lymphangiogenesis and angiogenesis in tumor metastasis. Cell Oncol (Dordr) (2016) 0.89
The histone variant H2A.X is a regulator of the epithelial-mesenchymal transition. Nat Commun (2016) 0.89
An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors. Genes Dev (2015) 0.88
Fra-1/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1/2 and TGFβ expression. Cell Death Differ (2014) 0.88
Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma. Genome Biol (2016) 0.88
HER2 mediated de novo production of TGFβ leads to SNAIL driven epithelial-to-mesenchymal transition and metastasis of breast cancer. Mol Oncol (2014) 0.87
Cancer Invasion: Patterns and Mechanisms. Acta Naturae (2015) 0.87
Forcing through Tumor Metastasis: The Interplay between Tissue Rigidity and Epithelial-Mesenchymal Transition. Trends Cell Biol (2015) 0.87
Effect of Cigarette Smoking on Epithelial to Mesenchymal Transition (EMT) in Lung Cancer. J Clin Med (2016) 0.86
Research on the efficacy of Celastrus Orbiculatus in suppressing TGF-β1-induced epithelial-mesenchymal transition by inhibiting HSP27 and TNF-α-induced NF-κ B/Snail signaling pathway in human gastric adenocarcinoma. BMC Complement Altern Med (2014) 0.86
Cancer Stem Cell Plasticity Drives Therapeutic Resistance. Cancers (Basel) (2016) 0.86
Antrodin C inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via suppression of Smad2/3 and β-catenin signaling pathways. PLoS One (2015) 0.86
Regulation of cancer metastasis by microRNAs. J Biomed Sci (2015) 0.86
Pancreatic cancer metastasis: are we being pre-EMTed? Curr Pharm Des (2015) 0.85
The miR-200 family differentially regulates sensitivity to paclitaxel and carboplatin in human ovarian carcinoma OVCAR-3 and MES-OV cells. Mol Oncol (2015) 0.84
The role of EMT and MET in cancer dissemination. Connect Tissue Res (2015) 0.84
Insulin-like growth factor binding protein 5 (IGFBP5) functions as a tumor suppressor in human melanoma cells. Oncotarget (2015) 0.84
The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer. J Transl Med (2014) 0.84
Colorectal Cancer Classification and Cell Heterogeneity: A Systems Oncology Approach. Int J Mol Sci (2015) 0.84
TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis. Genes Dev (2015) 0.83
Concise review: breast cancer stem cells: regulatory networks, stem cell niches, and disease relevance. Stem Cells Transl Med (2014) 0.83
Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient. Proc Natl Acad Sci U S A (2016) 0.83
TAZ promotes epithelial to mesenchymal transition via the upregulation of connective tissue growth factor expression in neuroblastoma cells. Mol Med Rep (2014) 0.83
Role of epithelial mesenchymal transition in prostate tumorigenesis. Curr Pharm Des (2015) 0.83
MicroRNA-17-5p induces drug resistance and invasion of ovarian carcinoma cells by targeting PTEN signaling. J Biol Res (Thessalon) (2015) 0.83
Causes and consequences of nuclear envelope alterations in tumour progression. Eur J Cell Biol (2016) 0.83
Inflammation increases NOTCH1 activity via MMP9 and is counteracted by Eicosapentaenoic Acid-free fatty acid in colon cancer cells. Sci Rep (2016) 0.83
STYK1 promotes epithelial-mesenchymal transition and tumor metastasis in human hepatocellular carcinoma through MEK/ERK and PI3K/AKT signaling. Sci Rep (2016) 0.82
Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival. Nat Commun (2016) 0.82
Claudin 1 in Breast Cancer: New Insights. J Clin Med (2015) 0.82
Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer. Physiol Genomics (2014) 0.82
Protein Kinase C-ε Promotes EMT in Breast Cancer. Breast Cancer (Auckl) (2014) 0.82
SHP2 positively regulates TGFβ1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1. J Biol Chem (2014) 0.82
STARD13-correlated ceRNA network inhibits EMT and metastasis of breast cancer. Oncotarget (2016) 0.82
Intratumoral heterogeneity: Clonal cooperation in epithelial-to-mesenchymal transition and metastasis. Cell Adh Migr (2014) 0.82
Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy. Semin Cancer Biol (2015) 0.82
Interleukin-17 promotes prostate cancer via MMP7-induced epithelial-to-mesenchymal transition. Oncogene (2016) 0.82
Aspirin inhibits epithelial-to-mesenchymal transition and migration of oncogenic K-ras-expressing non-small cell lung carcinoma cells by down-regulating E-cadherin repressor Slug. BMC Cancer (2016) 0.82
NK Cells, Tumor Cell Transition, and Tumor Progression in Solid Malignancies: New Hints for NK-Based Immunotherapy? J Immunol Res (2016) 0.81
Tumor-secreted Hsp90 subverts polycomb function to drive prostate tumor growth and invasion. J Biol Chem (2015) 0.81
Stromal-dependent tumor promotion by MIF family members. Cell Signal (2014) 0.81
Drastic morphological and molecular differences between lymph node micrometastatic tumors and macrometastatic tumors of lung adenocarcinoma. J Cancer Res Clin Oncol (2015) 0.81
The Multifunctional Protein Kinase C-ε in Cancer Development and Progression. Cancers (Basel) (2014) 0.81
Plasticity underlies tumor progression: role of Nodal signaling. Cancer Metastasis Rev (2016) 0.81
Activin B induces human endometrial cancer cell adhesion, migration and invasion by up-regulating integrin β3 via SMAD2/3 signaling. Oncotarget (2015) 0.81
Lineage factors and differentiation states in lung cancer progression. Oncogene (2015) 0.81
Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1αinduced IL-10. Oncoimmunology (2016) 0.81
Tumor treating fields inhibit glioblastoma cell migration, invasion and angiogenesis. Oncotarget (2016) 0.80
Gamma-smooth muscle actin expression is associated with epithelial-mesenchymal transition and stem-like properties in hepatocellular carcinoma. PLoS One (2015) 0.80
p53 controls colorectal cancer cell invasion by inhibiting the NF-κB-mediated activation of Fascin. Oncotarget (2015) 0.80
The emerging molecular machinery and therapeutic targets of metastasis. Trends Pharmacol Sci (2015) 0.80
Novel Molecular Markers for Breast Cancer. Biomark Cancer (2016) 0.80
RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1. Sci Rep (2015) 0.80
Epithelial-to-mesenchymal transition and cancer stem cells: emerging targets for novel cancer therapy. Cancer Gene Ther (2014) 0.80
Effect of IL-17A on the migration and invasion of NPC cells and related mechanisms. PLoS One (2014) 0.80
Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3β-Snail pathway. Cell Death Dis (2015) 0.80
Chronic TGFβ stimulation promotes the metastatic potential of lung cancer cells by Snail protein stabilization through integrin β3-Akt-GSK3β signaling. Oncotarget (2016) 0.80
Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity. BMC Cancer (2016) 0.80
Small cell lung cancer: Circulating tumor cells of extended stage patients express a mesenchymal-epithelial transition phenotype. Cell Adh Migr (2016) 0.80
Store-operated Ca(2+) entry regulates glioma cell migration and invasion via modulation of Pyk2 phosphorylation. J Exp Clin Cancer Res (2014) 0.80
Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth. Oncogene (2016) 0.80
TM4SF3 and AR: A Nuclear Complex that Stabilizes Both Proteins. Mol Endocrinol (2015) 0.79
Proteome profiling outperforms transcriptome profiling for co-expression based gene function prediction. Mol Cell Proteomics (2016) 0.79
Epithelial-mesenchymal transition in tissue repair and fibrosis. Cell Tissue Res (2016) 0.79
Activin B promotes endometrial cancer cell migration by down-regulating E-cadherin via SMAD-independent MEK-ERK1/2-SNAIL signaling. Oncotarget (2016) 0.79
Autonomous stimulation of cancer cell plasticity by the human NKG2D lymphocyte receptor coexpressed with its ligands on cancer cells. PLoS One (2014) 0.79
SIX1 coordinates with TGFβ signals to induce epithelial-mesenchymal transition in cervical cancer. Oncol Lett (2016) 0.79
Keloid-derived keratinocytes acquire a fibroblast-like appearance and an enhanced invasive capacity in a hypoxic microenvironment in vitro. Int J Mol Med (2015) 0.79
ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance. Oncogenesis (2016) 0.79
Tumour progression and metastasis. Ecancermedicalscience (2016) 0.79
In Vivo Visualization and Characterization of Epithelial-Mesenchymal Transition in Breast Tumors. Cancer Res (2016) 0.79
EMT-induced metabolite signature identifies poor clinical outcome. Oncotarget (2015) 0.79
Hallmarks of cancer: the next generation. Cell (2011) 140.01
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A (2001) 71.82
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17
Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer (2002) 34.99
The basics of epithelial-mesenchymal transition. J Clin Invest (2009) 32.82
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell (2004) 31.38
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol (2008) 24.27
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer (2003) 22.78
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol (2000) 21.15
The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol (2000) 15.78
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev (2008) 15.01
let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell (2007) 13.69
Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell (2009) 12.96
Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst (2008) 11.93
Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res (2010) 10.90
Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science (2013) 10.87
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep (2008) 10.71
The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem (2008) 10.08
The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst (2006) 10.06
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell (2001) 10.02
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol (2004) 9.80
EMT and dissemination precede pancreatic tumor formation. Cell (2012) 9.27
An overview of epithelio-mesenchymal transformation. Acta Anat (Basel) (1995) 9.18
Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One (2008) 8.97
Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol (2008) 8.72
A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature (1998) 8.48
Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci U S A (2001) 7.99
Systemic spread is an early step in breast cancer. Cancer Cell (2008) 7.91
A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res (2008) 7.45
Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol (2008) 7.37
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24
Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype. Cancer Res (2008) 6.95
Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma. Mod Pathol (2006) 6.86
Circulating tumor cells: approaches to isolation and characterization. J Cell Biol (2011) 6.54
The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res (2002) 6.47
Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell (2011) 6.21
Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer (2013) 6.13
Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell (2008) 5.88
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene (2005) 5.74
TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev (1996) 5.71
Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell (2012) 5.53
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A (2011) 5.53
Snail blocks the cell cycle and confers resistance to cell death. Genes Dev (2004) 5.34
Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition. Cancer Res (2005) 5.33
E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res (1995) 5.11
Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77
Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell (2009) 4.73
Cancer stem cells: an evolving concept. Nat Rev Cancer (2012) 4.57
E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO J (1995) 4.55
Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat Rev Mol Cell Biol (2003) 4.53
Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell (2012) 4.51
E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res (1994) 4.51
TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis. Curr Biol (1998) 4.44
Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol (1998) 4.43
Circulating tumor cells (CTC) detection: clinical impact and future directions. Cancer Lett (2007) 4.35
The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nat Rev Mol Cell Biol (2011) 4.24
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell (2006) 4.15
Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med (2011) 3.82
Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients. Breast Cancer Res (2009) 3.76
A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer. Gastroenterology (2006) 3.68
Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines. Clin Cancer Res (2006) 3.65
The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res (2005) 3.65
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res (2007) 3.53
Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J Clin Invest (2012) 3.45
SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions. Nucleic Acids Res (2005) 3.41
Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells. Cancer Res (2009) 3.30
ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell (2010) 3.25
miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle (2011) 3.15
Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. Cells Tissues Organs (2005) 3.10
A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions. J Biol Chem (2001) 3.03
p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J Exp Med (2011) 2.93
Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J Cell Biol (2005) 2.88
Mutations of the human E-cadherin (CDH1) gene. Hum Mutat (1998) 2.84
SNAI1 is required for tumor growth and lymph node metastasis of human breast carcinoma MDA-MB-231 cells. Cancer Res (2007) 2.80
TGF-β signaling and epithelial-mesenchymal transition in cancer progression. Curr Opin Oncol (2013) 2.80
Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. Mol Cell Biol (2004) 2.80
A cancer cell metalloprotease triad regulates the basement membrane transmigration program. Genes Dev (2006) 2.78
Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell (2011) 2.77
Epithelial-mesenchymal transition and cell cooperativity in metastasis. Cancer Res (2009) 2.68
miR-200b mediates post-transcriptional repression of ZFHX1B. RNA (2007) 2.67
Transforming growth factor-beta signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis. Cells Tissues Organs (2005) 2.64
The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation. J Cell Sci (2004) 2.63
Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest (2005) 2.61
Re-expression of E-cadherin, alpha-catenin and beta-catenin, but not of gamma-catenin, in metastatic tissue from breast cancer patients [seecomments]. J Pathol (2000) 2.61
Temporal progression of metastasis in lung: cell survival, dormancy, and location dependence of metastatic inefficiency. Cancer Res (2000) 2.58
Epithelial-mesenchymal transitions: insights from development. Development (2012) 2.58
The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis. RNA Biol (2009) 2.56
Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell (2002) 2.48
E-cadherin gene mutations in human gastric carcinoma cell lines. Proc Natl Acad Sci U S A (1994) 2.35
Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition. Mol Cancer (2010) 2.31
Host microenvironment in breast cancer development: epithelial-mesenchymal transition in breast cancer development. Breast Cancer Res (2003) 2.30
Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis. Cancer Res (2011) 2.29
Snail silencing effectively suppresses tumour growth and invasiveness. Oncogene (2006) 2.27
Epithelial-mesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth. Cancer Res (2008) 2.19
Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis. Dev Biol (1995) 2.19
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J Cell Biol (2011) 2.19
Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis. Oncogene (2007) 2.12
uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells. J Cell Biol (2007) 2.11
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res (2008) 7.91
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A (2010) 6.15
Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A (2007) 5.24
Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell (2012) 4.51
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science (2012) 3.72
Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells. Nat Mater (2010) 3.11
CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. J Clin Invest (2011) 2.90
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol (2010) 2.78
Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell (2011) 2.77
Expression divergence between duplicate genes. Trends Genet (2005) 2.69
Monitoring avian influenza A(H7N9) virus through national influenza-like illness surveillance, China. Emerg Infect Dis (2013) 2.61
Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis. Cancer Res (2011) 2.29
Insulin signaling meets vesicle traffic of GLUT4 at a plasma-membrane-activated fusion step. Cell Metab (2005) 2.20
Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality. Clin Nutr (2012) 2.17
Activation of STAT6 by STING is critical for antiviral innate immunity. Cell (2011) 2.08
Geometric strategies for neuroanatomic analysis from MRI. Neuroimage (2004) 2.07
Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proc Natl Acad Sci U S A (2007) 2.04
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet (2012) 2.02
Crop diversity for yield increase. PLoS One (2009) 2.02
Triptolide inhibits the growth and metastasis of solid tumors. Mol Cancer Ther (2003) 1.95
DUX4, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53-dependent myopathy in vivo. Ann Neurol (2010) 1.89
Processing pathway dependence of amorphous silica nanoparticle toxicity: colloidal vs pyrolytic. J Am Chem Soc (2012) 1.86
Th9 cells promote antitumor immune responses in vivo. J Clin Invest (2012) 1.80
Patterns of segmental duplication in the human genome. Mol Biol Evol (2004) 1.76
A novel role for TRPM8 in visceral afferent function. Pain (2011) 1.74
Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma. Cancer Res (2007) 1.69
Mer receptor tyrosine kinase signaling participates in platelet function. Arterioscler Thromb Vasc Biol (2004) 1.67
Visualizing extravasation dynamics of metastatic tumor cells. J Cell Sci (2010) 1.67
Syndrome differentiation in modern research of traditional Chinese medicine. J Ethnopharmacol (2012) 1.62
Myeloma cell line-derived, pooled heat shock proteins as a universal vaccine for immunotherapy of multiple myeloma. Blood (2009) 1.61
Enhancement of radiation cytotoxicity in breast-cancer cells by localized attachment of gold nanoparticles. Small (2008) 1.60
Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery. Mol Biosyst (2011) 1.58
Epidemiology of hand, foot, and mouth disease and genotype characterization of Enterovirus 71 in Jiangsu, China. J Clin Virol (2010) 1.58
Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis. Blood (2009) 1.58
A caspase cascade regulating developmental axon degeneration. J Neurosci (2012) 1.57
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. Proc Natl Acad Sci U S A (2013) 1.54
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proc Natl Acad Sci U S A (2013) 1.53
Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows. BMC Genomics (2011) 1.52
In vivo reduction of amyloid-beta by a mutant copper transporter. Proc Natl Acad Sci U S A (2003) 1.52
Measuring data abstraction quality in multiresolution visualizations. IEEE Trans Vis Comput Graph (2006) 1.51
The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections. EMBO J (2007) 1.49
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Am J Hum Genet (2012) 1.49
The human glomerular podocyte is a novel target for insulin action. Diabetes (2005) 1.49
Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter. Mol Cell Biol (2008) 1.48
Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus. Blood (2010) 1.47
Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5. Dev Biol (2009) 1.46
Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome. PLoS One (2011) 1.46
5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes (2003) 1.45
Clinicopathological features of gastric glomus tumor. World J Gastroenterol (2010) 1.44
Dual sgRNAs facilitate CRISPR/Cas9-mediated mouse genome targeting. FEBS J (2014) 1.43
Structure of Arabidopsis HYPONASTIC LEAVES1 and its molecular implications for miRNA processing. Structure (2010) 1.41
Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data. BMC Med Genet (2010) 1.41
Remission of rheumatoid arthritis and potential determinants: a national multi-center cross-sectional survey. Clin Rheumatol (2014) 1.41
A systematic review assessing the effectiveness of alendronate in reducing periprosthetic bone loss after cementless primary THA. Orthopedics (2011) 1.41
Intravenous Therapies for Complex Regional Pain Syndrome: A Systematic Review. Anesth Analg (2016) 1.39
GlcNAcylation plays an essential role in breast cancer metastasis. Cancer Res (2010) 1.39
Activation of Rap1B by G(i) family members in platelets. J Biol Chem (2002) 1.39
Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Mol Syst Biol (2011) 1.38
A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia. Mol Cancer Ther (2007) 1.36
Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization. Proc Natl Acad Sci U S A (2010) 1.36
Overexpression of SATB1 in laryngeal squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec (2010) 1.29
Epithelial-to-mesenchymal transition promotes tubulin detyrosination and microtentacles that enhance endothelial engagement. Cancer Res (2010) 1.29
A severe combined immunodeficient-hu in vivo mouse model of human primary mantle cell lymphoma. Clin Cancer Res (2008) 1.29
Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment. Neoplasia (2009) 1.27
Dickkopf-1 (DKK1) is a widely expressed and potent tumor-associated antigen in multiple myeloma. Blood (2007) 1.26
Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions. Proc Natl Acad Sci U S A (2011) 1.25
Murine Sall1 represses transcription by recruiting a histone deacetylase complex. J Biol Chem (2002) 1.25
Expression of a truncated Sall1 transcriptional repressor is responsible for Townes-Brocks syndrome birth defects. Hum Mol Genet (2003) 1.25
Twist1 induces CCL2 and recruits macrophages to promote angiogenesis. Cancer Res (2013) 1.24
Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma. Neurobiol Dis (2006) 1.23
Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region. J Biol Chem (2004) 1.23
Transcriptome profiling of resistant and susceptible Cavendish banana roots following inoculation with Fusarium oxysporum f. sp. cubense tropical race 4. BMC Genomics (2012) 1.23
Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells. Blood (2010) 1.23
Visible fluorescent detection of proteins in polyacrylamide gels without staining. Anal Biochem (2004) 1.21
Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. Am J Physiol Endocrinol Metab (2009) 1.21
Tumor evasion of the immune system: inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma. Blood (2005) 1.21
Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex. Mol Cell (2013) 1.21
Spinal cord injury-induced attenuation of GABAergic inhibition in spinal dorsal horn circuits is associated with down-regulation of the chloride transporter KCC2 in rat. J Physiol (2008) 1.20
Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton. Dev Biol (2007) 1.19
Increased population of CD4(+)CD25(high), regulatory T cells with their higher apoptotic and proliferating status in peripheral blood of acute myeloid leukemia patients. Eur J Haematol (2005) 1.18
Engineering retinal progenitor cell and scrollable poly(glycerol-sebacate) composites for expansion and subretinal transplantation. Biomaterials (2009) 1.18
Endocytosis of the seven-transmembrane RGS1 protein activates G-protein-coupled signalling in Arabidopsis. Nat Cell Biol (2012) 1.18
The carbonic anhydrase isoforms of Chlamydomonas reinhardtii: intracellular location, expression, and physiological roles. Photosynth Res (2011) 1.17
Toxicity screening by electrochemical detection of DNA damage by metabolites generated in situ in ultrathin DNA-enzyme films. J Am Chem Soc (2003) 1.15
Synthetic two-piece and three-piece split inteins for protein trans-splicing. J Biol Chem (2004) 1.14
IDH1 and IDH2 mutation analysis in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome. Ann Hematol (2011) 1.14
Structural basis for RNA-silencing suppression by Tomato aspermy virus protein 2b. EMBO Rep (2008) 1.13
Infrared and infrared emission spectroscopic study of typical Chinese kaolinite and halloysite. Spectrochim Acta A Mol Biomol Spectrosc (2010) 1.12
Leukemic cell intracellular responses to nanosecond electric fields. Biochem Biophys Res Commun (2004) 1.12
Traditional chinese medicine zheng in the era of evidence-based medicine: a literature analysis. Evid Based Complement Alternat Med (2012) 1.12
Critical roles of Raf/MEK/ERK and PI3K/AKT signaling and inactivation of p38 MAP kinase in the differentiation and survival of monocyte-derived immature dendritic cells. Exp Hematol (2005) 1.12
CYP2E1 mediated isoniazid-induced hepatotoxicity in rats. Acta Pharmacol Sin (2004) 1.11
Cocirculation of two transmission lineages of echovirus 6 in jinan, china, as revealed by environmental surveillance and sequence analysis. Appl Environ Microbiol (2011) 1.11
Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrP(C)-deficiency. Proc Natl Acad Sci U S A (2012) 1.11
Marine N-3 polyunsaturated fatty acids are inversely associated with risk of type 2 diabetes in Asians: a systematic review and meta-analysis. PLoS One (2012) 1.10
PP2A:B56epsilon is required for eye induction and eye field separation. Dev Biol (2006) 1.10