Covariance of charged amino acids at positions 322 and 440 of HIV-1 Env contributes to coreceptor specificity of subtype B viruses, and can be used to improve the performance of V3 sequence-based coreceptor usage prediction algorithms.

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🔗 View Article (PMC 4196930)

Published in PLoS One on October 14, 2014

Authors

Kieran Cashin1, Jasminka Sterjovski2, Katherine L Harvey1, Paul A Ramsland3, Melissa J Churchill4, Paul R Gorry5

Author Affiliations

1: Center for Biomedical Research, Burnet Institute, Melbourne, Australia; Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia.
2: Center for Biomedical Research, Burnet Institute, Melbourne, Australia.
3: Center for Biomedical Research, Burnet Institute, Melbourne, Australia; Department of Surgery (Austin Health), University of Melbourne, Melbourne, Australia; Department of Immunology, Monash University, Melbourne, Australia; School of Biomedical Sciences, CHIRI Biosciences, Faculty of Health Sciences, Curtin University, Perth, Australia.
4: Center for Biomedical Research, Burnet Institute, Melbourne, Australia; Department of Microbiology, Monash University, Melbourne, Australia; Department of Medicine, Monash University, Melbourne, Australia.
5: Center for Biomedical Research, Burnet Institute, Melbourne, Australia; Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia; Department of Infectious Diseases, Monash University, Melbourne, Australia.

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