The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation.

PubWeight™: 0.83‹?›

🔗 View Article (PMID 25330774)

Published in Proteomics on December 17, 2014

Authors

Stan Pasyk1, Steven Molinski, Saumel Ahmadi, Mohabir Ramjeesingh, Ling-Jun Huan, Stephanie Chin, Kai Du, Herman Yeger, Paul Taylor, Michael F Moran, Christine E Bear

Author Affiliations

1: Programme in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada; Department of Biochemistry, The University of Toronto, Toronto, ON, Canada.

Articles by these authors

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66

Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol (2007) 8.16

Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening. J Clin Invest (2005) 4.19

An Archaeopteryx-like theropod from China and the origin of Avialae. Nature (2011) 3.77

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol (2004) 3.45

Insights into antifolate resistance from malarial DHFR-TS structures. Nat Struct Biol (2003) 3.20

Peripheral protein quality control removes unfolded CFTR from the plasma membrane. Science (2010) 2.92

Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. J Cell Biol (2004) 2.74

Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell. Cancer Res (2007) 2.56

Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science (2004) 2.39

Single-center experience of encapsulating peritoneal sclerosis in patients on peritoneal dialysis for end-stage renal failure. Kidney Int (2005) 2.29

Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspring. Circulation (2004) 2.28

Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating. J Biol Chem (2003) 2.25

Use of a computerized guideline for glucose regulation in the intensive care unit improved both guideline adherence and glucose regulation. J Am Med Inform Assoc (2004) 1.85

Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner. J Biol Chem (2012) 1.80

Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction. Stem Cells (2008) 1.78

Clinical Practice Guidelines and Recommendations on Peritoneal Dialysis Adequacy 2011. Perit Dial Int (2011) 1.76

Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function. Cell (2012) 1.73

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nat Biotechnol (2012) 1.73

Reduction and return of infectious trachoma in severely affected communities in Ethiopia. PLoS Negl Trop Dis (2009) 1.68

Computer-aided detection in the United Kingdom National Breast Screening Programme: prospective study. Radiology (2005) 1.63

Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design. Proc Natl Acad Sci U S A (2005) 1.57

The cystic fibrosis-causing mutation deltaF508 affects multiple steps in cystic fibrosis transmembrane conductance regulator biogenesis. J Biol Chem (2010) 1.55

Mechanism of Mos1 transposition: insights from structural analysis. EMBO J (2006) 1.48

Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol (2006) 1.47

CFTR directly mediates nucleotide-regulated glutathione flux. EMBO J (2003) 1.45

A strategy for modulation of enzymes in the ubiquitin system. Science (2013) 1.43

CCN3 (NOV) is a negative regulator of CCN2 (CTGF) and a novel endogenous inhibitor of the fibrotic pathway in an in vitro model of renal disease. Am J Pathol (2009) 1.42

Plasticity of polyubiquitin recognition as lysosomal targeting signals by the endosomal sorting machinery. Mol Biol Cell (2007) 1.37

The expression of ccn3(nov) gene in musculoskeletal tumors. Am J Pathol (2002) 1.35

Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome". Cell (2011) 1.34

Community risk factors for ocular Chlamydia infection in Niger: pre-treatment results from a cluster-randomized trachoma trial. PLoS Negl Trop Dis (2012) 1.33

Myxoma virus M11L prevents apoptosis through constitutive interaction with Bak. J Virol (2004) 1.27

Probing structure-function relationships and gating mechanisms in the CorA Mg2+ transport system. J Biol Chem (2008) 1.25

CD271(+) bone marrow mesenchymal stem cells may provide a niche for dormant Mycobacterium tuberculosis. Sci Transl Med (2013) 1.22

A small-molecule modulator interacts directly with deltaPhe508-CFTR to modify its ATPase activity and conformational stability. Mol Pharmacol (2009) 1.21

Evidence for a superoxide permeability pathway in endosomal membranes. Mol Cell Biol (2008) 1.21

Pulmonary neuroendocrine cell system in pediatric lung disease-recent advances. Pediatr Dev Pathol (2007) 1.21

Automated 2D peptide separation on a 1D nano-LC-MS system. J Proteome Res (2009) 1.19

Thymidylate synthase expression and outcome of patients receiving pemetrexed for advanced nonsquamous non-small-cell lung cancer in a prospective blinded assessment phase II clinical trial. J Thorac Oncol (2013) 1.17

The chloride channel ClC-4 contributes to endosomal acidification and trafficking. J Biol Chem (2003) 1.17

Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma. Mol Cancer Ther (2005) 1.17

Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma. Anticancer Res (2004) 1.16

S-nitrosylation of AtSABP3 antagonizes the expression of plant immunity. J Biol Chem (2008) 1.16

The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia. J Biol Chem (2003) 1.16

Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clin Cancer Res (2011) 1.15

Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo. FASEB J (2005) 1.14

Potential cellular conformations of the CCN3(NOV) protein. Cell Commun Signal (2004) 1.14

A structure-based mutational analysis of cyclophilin 40 identifies key residues in the core tetratricopeptide repeat domain that mediate binding to Hsp90. J Biol Chem (2002) 1.13

Visuomotor priming by pictures of hand postures: perspective matters. Neuropsychologia (2003) 1.12

Structural basis for alginate secretion across the bacterial outer membrane. Proc Natl Acad Sci U S A (2011) 1.11

A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma. Cancer Res (2005) 1.11

Octaheme tetrathionate reductase is a respiratory enzyme with novel heme ligation. Nat Struct Mol Biol (2004) 1.10

A chemical corrector modifies the channel function of F508del-CFTR. Mol Pharmacol (2010) 1.10

Cystic fibrosis transmembrane conductance regulator in human muscle: Dysfunction causes abnormal metabolic recovery in exercise. Ann Neurol (2010) 1.10

Dominant and recessive distal renal tubular acidosis mutations of kidney anion exchanger 1 induce distinct trafficking defects in MDCK cells. Traffic (2006) 1.10

Epidermal growth factor receptor variant III-induced glioma invasion is mediated through myristoylated alanine-rich protein kinase C substrate overexpression. Cancer Res (2009) 1.10

In vivo antitumor and antimetastatic activity of sunitinib in preclinical neuroblastoma mouse model. Neoplasia (2009) 1.09

Effect of high-dose intravenous vitamin C on inflammation in cancer patients. J Transl Med (2012) 1.09

A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood (2010) 1.09

Derivation and characterization of a Wilms' tumour cell line, WiT 49. Int J Cancer (2003) 1.09

Dimeric cystic fibrosis transmembrane conductance regulator exists in the plasma membrane. Biochem J (2003) 1.08

Tissue microenvironment modulates CXCR4 expression and tumor metastasis in neuroblastoma. Neoplasia (2007) 1.08

A pilot clinical study of continuous intravenous ascorbate in terminal cancer patients. P R Health Sci J (2005) 1.08

Multi-intervention management of calciphylaxis: a report of 7 cases. Am J Kidney Dis (2011) 1.08

The human phosphotyrosine signaling network: evolution and hotspots of hijacking in cancer. Genome Res (2011) 1.07

A gene expression signature for relapse of primary wilms tumors. Cancer Res (2005) 1.07

Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041. Mol Cell Proteomics (2009) 1.07

GABAergic circuits control spike-timing-dependent plasticity. J Neurosci (2013) 1.05

Homologues of human macrophage migration inhibitory factor from a parasitic nematode. Gene cloning, protein activity, and crystal structure. J Biol Chem (2002) 1.04

Pulmonary neuroendocrine cells, airway innervation, and smooth muscle are altered in Cftr null mice. Am J Respir Cell Mol Biol (2006) 1.04

The Walker B motif of the second nucleotide-binding domain (NBD2) of CFTR plays a key role in ATPase activity by the NBD1-NBD2 heterodimer. Biochem J (2007) 1.03

Expression, purification and preliminary crystallographic studies of a single-point mutant of Mos1 mariner transposase. Acta Crystallogr D Biol Crystallogr (2004) 1.03

Squalene selectively protects mouse bone marrow progenitors against cisplatin and carboplatin-induced cytotoxicity in vivo without protecting tumor growth. Neoplasia (2008) 1.03

A heteromeric complex of the two nucleotide binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) mediates ATPase activity. J Biol Chem (2004) 1.02

Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease. Biochem J (2009) 1.02

A systematic review of computer-assisted diagnosis in diagnostic cancer imaging. Eur J Radiol (2011) 1.02

A mass spectrometry based method for distinguishing between symmetrically and asymmetrically dimethylated arginine residues. Rapid Commun Mass Spectrom (2004) 1.01

Selected Reaction Monitoring (SRM) Analysis of Epidermal Growth Factor Receptor (EGFR) in Formalin Fixed Tumor Tissue. Clin Proteomics (2012) 1.01

NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia. J Pathol (2003) 0.99

Making decisions about mammography. BMJ (2005) 0.99