Published in P R Health Sci J on December 01, 2005
Study of High Dose Intravenous (IV) Ascorbic Acid in Measurable Solid Tumor Disease | NCT01125449
Ascorbic acid: chemistry, biology and the treatment of cancer. Biochim Biophys Acta (2012) 1.89
Vitamin C and cancer revisited. Proc Natl Acad Sci U S A (2008) 1.24
Effect of high-dose intravenous vitamin C on inflammation in cancer patients. J Transl Med (2012) 1.09
Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer. Cancer Chemother Pharmacol (2013) 1.07
Parenteral ascorbate as a cancer therapeutic: a reassessment based on pharmacokinetics. Antioxid Redox Signal (2013) 0.97
Clinical experience with intravenous administration of ascorbic acid: achievable levels in blood for different states of inflammation and disease in cancer patients. J Transl Med (2013) 0.90
Is there a role for oral or intravenous ascorbate (vitamin C) in treating patients with cancer? A systematic review. Oncologist (2015) 0.90
Extracellular iron diminishes anticancer effects of vitamin C: an in vitro study. Sci Rep (2014) 0.88
Ascorbate inhibition of angiogenesis in aortic rings ex vivo and subcutaneous Matrigel plugs in vivo. J Angiogenes Res (2010) 0.88
Epigenetic impacts of ascorbate on human metastatic melanoma cells. Front Oncol (2014) 0.88
Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress. BMC Complement Altern Med (2012) 0.87
Molecular mechanisms of pharmacological doses of ascorbate on cancer cells. Wien Med Wochenschr (2015) 0.84
Ascorbate as a co-factor for fe- and 2-oxoglutarate dependent dioxygenases: physiological activity in tumor growth and progression. Front Oncol (2014) 0.81
Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice. Behav Brain Res (2014) 0.81
Preclinical demonstration of synergistic Active Nutrients/Drug (AND) combination as a potential treatment for malignant pleural mesothelioma. PLoS One (2013) 0.80
Treatment of Pancreatic Cancer with Pharmacological Ascorbate. Curr Pharm Biotechnol (2015) 0.78
High-dose intravenous vitamin C combined with cytotoxic chemotherapy in patients with advanced cancer: a phase I-II clinical trial. PLoS One (2015) 0.77
Modulation of Cytokines in Cancer Patients by Intravenous Ascorbate Therapy. Med Sci Monit (2016) 0.77
Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects. Sci Rep (2016) 0.77
Schedule Dependence in Cancer Therapy: Intravenous Vitamin C and the Systemic Saturation Hypothesis. J Orthomol Med (2012) 0.75
High-Dose Intravenous Vitamin C Treatment of a Child with Neurofibromatosis Type 1 and Optic Pathway Glioma: A Case Report. Am J Case Rep (2016) 0.75
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66
Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol (2007) 8.16
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol (2004) 3.45
Insights into antifolate resistance from malarial DHFR-TS structures. Nat Struct Biol (2003) 3.20
Single-center experience of encapsulating peritoneal sclerosis in patients on peritoneal dialysis for end-stage renal failure. Kidney Int (2005) 2.29
Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspring. Circulation (2004) 2.28
Endometrial regenerative cells: a novel stem cell population. J Transl Med (2007) 2.19
Use of a computerized guideline for glucose regulation in the intensive care unit improved both guideline adherence and glucose regulation. J Am Med Inform Assoc (2004) 1.85
Clinical Practice Guidelines and Recommendations on Peritoneal Dialysis Adequacy 2011. Perit Dial Int (2011) 1.76
Immunotherapy for melanoma: current status and perspectives. J Immunother (2010) 1.72
Computer-aided detection in the United Kingdom National Breast Screening Programme: prospective study. Radiology (2005) 1.63
Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design. Proc Natl Acad Sci U S A (2005) 1.57
Cutaneous sarcoidosis and malignancy: An association between sarcoidosis with skin manifestations and systemic neoplasia. Dermatol Online J (2011) 1.49
Mechanism of Mos1 transposition: insights from structural analysis. EMBO J (2006) 1.48
Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol (2006) 1.47
Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome". Cell (2011) 1.34
Exosomes as a tumor immune escape mechanism: possible therapeutic implications. J Transl Med (2008) 1.28
Allogeneic endometrial regenerative cells: an "Off the shelf solution" for critical limb ischemia? J Transl Med (2008) 1.27
Mesenchymal stem cells as anti-inflammatories: implications for treatment of Duchenne muscular dystrophy. Cell Immunol (2010) 1.19
Thymidylate synthase expression and outcome of patients receiving pemetrexed for advanced nonsquamous non-small-cell lung cancer in a prospective blinded assessment phase II clinical trial. J Thorac Oncol (2013) 1.17
S-nitrosylation of AtSABP3 antagonizes the expression of plant immunity. J Biol Chem (2008) 1.16
Orthomolecular oncology review: ascorbic acid and cancer 25 years later. Integr Cancer Ther (2005) 1.15
Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo. FASEB J (2005) 1.14
A structure-based mutational analysis of cyclophilin 40 identifies key residues in the core tetratricopeptide repeat domain that mediate binding to Hsp90. J Biol Chem (2002) 1.13
Visuomotor priming by pictures of hand postures: perspective matters. Neuropsychologia (2003) 1.12
Feasibility investigation of allogeneic endometrial regenerative cells. J Transl Med (2009) 1.10
Octaheme tetrathionate reductase is a respiratory enzyme with novel heme ligation. Nat Struct Mol Biol (2004) 1.10
Safety evaluation of allogeneic umbilical cord blood mononuclear cell therapy for degenerative conditions. J Transl Med (2010) 1.09
Effect of high-dose intravenous vitamin C on inflammation in cancer patients. J Transl Med (2012) 1.09
Feasibility of combination allogeneic stem cell therapy for spinal cord injury: a case report. Int Arch Med (2010) 1.09
Multi-intervention management of calciphylaxis: a report of 7 cases. Am J Kidney Dis (2011) 1.08
Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041. Mol Cell Proteomics (2009) 1.07
Homologues of human macrophage migration inhibitory factor from a parasitic nematode. Gene cloning, protein activity, and crystal structure. J Biol Chem (2002) 1.04
Expression, purification and preliminary crystallographic studies of a single-point mutant of Mos1 mariner transposase. Acta Crystallogr D Biol Crystallogr (2004) 1.03
A systematic review of computer-assisted diagnosis in diagnostic cancer imaging. Eur J Radiol (2011) 1.02
Tumor vaccines in 2010: need for integration. Cell Immunol (2010) 1.02
Selected Reaction Monitoring (SRM) Analysis of Epidermal Growth Factor Receptor (EGFR) in Formalin Fixed Tumor Tissue. Clin Proteomics (2012) 1.01
Making decisions about mammography. BMJ (2005) 0.99
Measurement of protein phosphorylation stoichiometry by selected reaction monitoring mass spectrometry. J Proteome Res (2010) 0.99
Structures of immunophilins and their ligand complexes. Curr Top Med Chem (2003) 0.98
Crystal structure of a thermostable lipase from Bacillus stearothermophilus P1. J Mol Biol (2002) 0.98
System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma. Clin Cancer Res (2010) 0.97
EDULISS: a small-molecule database with data-mining and pharmacophore searching capabilities. Nucleic Acids Res (2010) 0.96
Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop. Structure (2003) 0.96
Intravenous ascorbic acid: protocol for its application and use. P R Health Sci J (2003) 0.96
Multiple myeloma phosphotyrosine proteomic profile associated with FGFR3 expression, ligand activation, and drug inhibition. Proc Natl Acad Sci U S A (2009) 0.96
Intravenous vitamin C as a chemotherapy agent: a report on clinical cases. P R Health Sci J (2004) 0.95
Pharmacokinetics of vitamin C: insights into the oral and intravenous administration of ascorbate. P R Health Sci J (2008) 0.95
Effect of weight reduction on cardiovascular risk factors and CD34-positive cells in circulation. Int J Med Sci (2011) 0.95
Placental mesenchymal and cord blood stem cell therapy for dilated cardiomyopathy. Reprod Biomed Online (2008) 0.93
Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor. J Biol Chem (2013) 0.92
Anti-angiogenic effect of high doses of ascorbic acid. J Transl Med (2008) 0.92
Stem cell therapy for autism. J Transl Med (2007) 0.91
nemy encodes a cytochrome b561 that is required for Drosophila learning and memory. Proc Natl Acad Sci U S A (2008) 0.91
Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor. J Proteome Res (2008) 0.91
Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb. Mol Cell Proteomics (2012) 0.91
Primary tumor xenografts of human lung adeno and squamous cell carcinoma express distinct proteomic signatures. J Proteome Res (2010) 0.91
Emerging applications for phospho-proteomics in cancer molecular therapeutics. Biochim Biophys Acta (2006) 0.91
Cancer is a functional repair tissue. Med Hypotheses (2005) 0.89
Maternal obesity programmes offspring development of non-alcoholic fatty pancreas disease. Biochem Biophys Res Commun (2010) 0.88
Omitting elective nodal irradiation during thoracic irradiation in limited-stage small cell lung cancer--evidence from a phase II trial. Lung Cancer (2011) 0.88
Distinct properties of murine alpha 5 gamma-aminobutyric acid type a receptors revealed by biochemical fractionation and mass spectroscopy. J Neurosci Res (2009) 0.88
Liquid chromatography-tandem mass spectrometry or automated immunoassays: what are the future trends in therapeutic drug monitoring? Clin Chem (2012) 0.87
L-ascorbic acid represses constitutive activation of NF-kappaB and COX-2 expression in human acute myeloid leukemia, HL-60. J Cell Biochem (2004) 0.87
Autologous stromal vascular fraction cells: a tool for facilitating tolerance in rheumatic disease. Cell Immunol (2010) 0.86
Identification of protein binding surfaces using surface triplet propensities. Bioinformatics (2010) 0.86
The effects of the odstock drop foot stimulator on perceived quality of life for people with stroke and multiple sclerosis. Neuromodulation (2010) 0.86
Dietary patterns and their association with sociodemographic characteristics and perceived academic stress of college students in Puerto Rico. P R Health Sci J (2013) 0.86
Odin (ANKS1A) modulates EGF receptor recycling and stability. PLoS One (2013) 0.86
The king is dead, long live the king: entering a new era of stem cell research and clinical development. J Transl Med (2011) 0.86
Inhibition of intracranial glioma growth by endometrial regenerative cells. Cell Cycle (2009) 0.85
Combination stem cell therapy for heart failure. Int Arch Med (2010) 0.85
Accelerometer-triggered electrical stimulation for reach and grasp in chronic stroke patients: a pilot study. Neurorehabil Neural Repair (2011) 0.85
Use of G-CSF during concurrent chemotherapy and thoracic radiotherapy in patients with limited-stage small-cell lung cancer safety data from a phase II trial. Lung Cancer (2011) 0.85
A phase I study of Vandetanib in combination with vinorelbine/cisplatin or gemcitabine/cisplatin as first-line treatment for advanced non-small cell lung cancer. J Thorac Oncol (2010) 0.85
Safety and Immunogenicity of MAGE-A3 Cancer Immunotherapeutic with or without Adjuvant Chemotherapy in Patients with Resected Stage IB to III MAGE-A3-Positive Non-Small-Cell Lung Cancer. J Thorac Oncol (2015) 0.84
Circulating endothelial progenitor cells: a new approach to anti-aging medicine? J Transl Med (2009) 0.84
Atypical (RIO) protein kinases from Haemonchus contortus--promise as new targets for nematocidal drugs. Biotechnol Adv (2011) 0.84
Antigen-specific therapy of rheumatoid arthritis. Expert Opin Biol Ther (2008) 0.83
The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation. Proteomics (2014) 0.83
Could metabolic syndrome, lipodystrophy, and aging be mesenchymal stem cell exhaustion syndromes? Stem Cells Int (2011) 0.83
The bio-energetic theory of carcinogenesis. Med Hypotheses (2012) 0.83
Collapsing glomerulopathy coexisting with membranous glomerulonephritis in native kidney biopsies: a report of 3 HIV-negative patients. Am J Kidney Dis (2003) 0.82
Vascular access planning in peritoneal dialysis patients. Perit Dial Int (2008) 0.82
Autologous stromal vascular fraction therapy for rheumatoid arthritis: rationale and clinical safety. Int Arch Med (2012) 0.82