Design and synthesis of potent hydroxamate inhibitors with increased selectivity within the gelatinase family.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 25348733)

Published in Org Biomol Chem on January 07, 2015

Authors

José María Zapico1, Anna Puckowska, Kamila Filipiak, Claire Coderch, Beatriz de Pascual-Teresa, Ana Ramos

Author Affiliations

1: Departamento de Química y Bioquímica, Facultad de Farmacia, Universidad CEU San Pablo, Urbanización Monteprincipe, 28668 Madrid, Spain. bpaster@ceu.es aramgon@ceu.es.

Articles by these authors

Cerebral microarteriovenous malformations: a series of 28 cases. J Neurosurg (2013) 2.13

Is the glycolytic flux in Lactococcus lactis primarily controlled by the redox charge? Kinetics of NAD(+) and NADH pools determined in vivo by 13C NMR. J Biol Chem (2002) 1.62

Comparative study of the thermostabilizing properties of mannosylglycerate and other compatible solutes on model enzymes. Extremophiles (2002) 1.44

Effect of different NADH oxidase levels on glucose metabolism by Lactococcus lactis: kinetics of intracellular metabolite pools determined by in vivo nuclear magnetic resonance. Appl Environ Microbiol (2002) 1.21

OXA-23-producing Acinetobacter baumannii: a new hotspot of diversity in Rio de Janeiro? J Antimicrob Chemother (2010) 1.17

Engineering Lactococcus lactis for production of mannitol: high yields from food-grade strains deficient in lactate dehydrogenase and the mannitol transport system. Appl Environ Microbiol (2004) 1.12

Spontaneous hemorrhage into a lumbar synovial cyst. Eur Spine J (2010) 1.04

Emphysematous pyelonephritis in dialysis patient after embolization of failed allograft. Urology (2007) 1.03

Catabolism of mannitol in Lactococcus lactis MG1363 and a mutant defective in lactate dehydrogenase. Microbiology (2002) 1.02

The expanding spectrum of biological actions of vitamin D. Nephrol Dial Transplant (2010) 1.00

Silent cerebral white matter lesions and their relationship with vascular risk factors in middle-aged predialysis patients with CKD. Am J Kidney Dis (2006) 0.99

Pannus resolution after occipitocervical fusion in a non-rheumatoid atlanto-axial instability. Eur Spine J (2005) 0.99

Association of low serum 25-hydroxyvitamin D levels in pregnancy with glucose homeostasis and obstetric and newborn outcomes. Endocr Pract (2012) 0.99

Brown-Sequard syndrome after blunt cervical spine trauma: clinical and radiological correlations. Eur Spine J (2007) 0.98

The role of MR imaging in assessing prognosis after severe and moderate head injury. Acta Neurochir (Wien) (2009) 0.98

Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel. Chem Biol (2008) 0.95

Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases. J Med Chem (2005) 0.95

Leuconostoc ficulneum sp. nov., a novel lactic acid bacterium isolated from a ripe fig, and reclassification of Lactobacillus fructosus as Leuconostoc fructosum comb. nov. Int J Syst Evol Microbiol (2002) 0.91

Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach. ACS Chem Biol (2011) 0.90

Enhancement of trehalose production in dairy propionibacteria through manipulation of environmental conditions. Int J Food Microbiol (2004) 0.90

Acute perfusion changes after spontaneous SAH: a perfusion CT study. Acta Neurochir (Wien) (2012) 0.89

Botulinum toxin-responsive oromandibular dystonia in cerebrotendinous xanthomatosis. Parkinsonism Relat Disord (2011) 0.88

Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A(1): implications for antitumoral activity. Cancer Res (2011) 0.87

High-level production of the low-calorie sugar sorbitol by Lactobacillus plantarum through metabolic engineering. Appl Environ Microbiol (2007) 0.87

Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities. Eur J Med Chem (2005) 0.86

Lateral medullary infarction secondary to vertebral artery dissection presenting as a trigeminal autonomic cephalalgia. Headache (2004) 0.86

Structure of micelle-bound adrenomedullin: a first step toward the analysis of its interactions with receptors and small molecules. Biopolymers (2011) 0.85

Potential anti-inflammatory, anti-adhesive, anti/estrogenic, and angiotensin-converting enzyme inhibitory activities of anthocyanins and their gut metabolites. Genes Nutr (2012) 0.85

Synthesis and biological evaluation of analogues of butyrolactone I and molecular model of its interaction with CDK2. Org Biomol Chem (2004) 0.84

Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code. Nucleic Acids Res (2013) 0.84

Ofloxacin-like antibiotics inhibit pneumococcal cell wall-degrading virulence factors. J Biol Chem (2005) 0.84

Community-partnered research conference model: the experience of Community Partners in Care study. Prog Community Health Partnersh (2014) 0.83

Targeting matrix metalloproteinases: exploring the dynamics of the s1' pocket in the design of selective, small molecule inhibitors. J Med Chem (2014) 0.82

A severe case of Hirayama disease successfully treated by anterior cervical fusion. J Neurosurg Spine (2013) 0.81

Molecular recognition of epothilones by microtubules and tubulin dimers revealed by biochemical and NMR approaches. ACS Chem Biol (2014) 0.80

An integrated computational and experimental approach to gaining selectivity for MMP-2 within the gelatinase subfamily. Chembiochem (2014) 0.80

Perfusion computed tomography in a dural arteriovenous fistula presenting with focal signs: vascular congestion as a cause of reversible neurologic dysfunction. Neurosurgery (2010) 0.80

The development of eating disorders after bariatric surgery. Eat Disord (2013) 0.80

Dietary gallic acid and anthocyanin cytotoxicity on human fibrosarcoma HT1080 cells. A study on the mode of action. Food Funct (2014) 0.80

New analogues of amonafide and elinafide, containing aromatic heterocycles: synthesis, antitumor activity, molecular modeling, and DNA binding properties. J Med Chem (2004) 0.80

Adrenomedullin: a new and promising target for drug discovery. Expert Opin Ther Targets (2006) 0.80

Synthesis and biological evaluation of a new series of highly functionalized 7'-homo-anhydrovinblastine derivatives. J Med Chem (2013) 0.79

Typical trigeminal neuralgia associated with brainstem white matter lesions on MRI in patients without criteria of multiple sclerosis. Acta Neurochir (Wien) (2008) 0.78

A role for the membrane proteome in human chronic kidney disease erythrocytes. Transl Res (2012) 0.78

Chromophore-modified bisnaphthalimides: DNA recognition, topoisomerase inhibition, and cytotoxic properties of two mono- and bisfuronaphthalimides. Biochemistry (2003) 0.78

Volumetric analysis of subarachnoid hemorrhage: assessment of the reliability of two computerized methods and their comparison with other radiographic scales. J Neurosurg (2012) 0.77

Mechanistic insight into the catalytic activity of ββα-metallonucleases from computer simulations: Vibrio vulnificus periplasmic nuclease as a test case. Chembiochem (2011) 0.77

Higher glutamate to glutamine ratios in occipital regions in women with migraine during the interictal state. Headache (2012) 0.77

Symmetric dithiodigalactoside: strategic combination of binding studies and detection of selectivity between a plant toxin and human lectins. Org Biomol Chem (2011) 0.77

Synthesis, antitumor activity, molecular modeling, and DNA binding properties of a new series of imidazonaphthalimides. J Med Chem (2002) 0.77

Potent "clicked" MMP2 inhibitors: synthesis, molecular modeling and biological exploration. Org Biomol Chem (2011) 0.77

Comparison between perimesencephalic nonaneurysmal subarachnoid hemorrhage and subarachnoid hemorrhage caused by posterior circulation aneurysms. J Neurosurg (2003) 0.77

Pattern of and risk factors for brain microbleeds in neurodegenerative dementia. Am J Alzheimers Dis Other Demen (2014) 0.76

Towards β-selectivity in functional estrogen receptor antagonists. Org Biomol Chem (2012) 0.76

Small-molecule negative modulators of adrenomedullin: design, synthesis, and 3D-QSAR study. ChemMedChem (2008) 0.76

Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing syndrome treated with microvascular decompression of the trigeminal nerve: case report. Neurosurgery (2005) 0.76

A variant of WEBINO syndrome after top of the basilar artery stroke. Clin Neurol Neurosurg (2010) 0.76

Venous angioma associated with atypical ophthalmoplegic migraine. Headache (2004) 0.76

Human protein kinase CK2 phosphorylates matrix metalloproteinase 2 and inhibits its activity. Chembiochem (2014) 0.76

New scaffolds for the design of selective estrogen receptor modulators. Org Biomol Chem (2008) 0.75

Multisite-directed inhibitors of protein kinase CK2: new challenges. Mol Cell Biochem (2011) 0.75

[The individual with leg ulcer and structured nursing care intervention: a systematic literature review]. Rev Esc Enferm USP (2012) 0.75

Synthesis, biological evaluation, and three-dimensional quantitative structure-activity relationship study of small-molecule positive modulators of adrenomedullin. J Med Chem (2005) 0.75

Synthesis, cytotoxic activities and proposed mode of binding of a series of bis([(9-oxo-9,10-dihydroacridine-4-carbonyl)amino]alkyl) alkylamines. Eur J Med Chem (2002) 0.75

Tumefactive multiple sclerosis requiring emergency craniotomy: case report and literature review. Neurocirugia (Astur) (2013) 0.75

Comparative binding energy COMBINE analysis for understanding the binding determinants of type II dehydroquinase inhibitors. ChemMedChem (2013) 0.75

Progress towards water-soluble triazole-based selective MMP-2 inhibitors. Org Biomol Chem (2013) 0.75

Identification of first proadrenomedullin N-terminal 20 peptide (PAMP) modulator by means of virtual screening and NMR interaction experiments. Eur J Med Chem (2012) 0.75

Synthesis, biological evaluation and DNA binding properties of novel mono and bisnaphthalimides. Org Biomol Chem (2003) 0.75

One-pot synthesis of vinca alkaloids-phomopsin hybrids. J Med Chem (2014) 0.75

PET-Florbetapir findings in primary cerebral amyloidoma. J Neurol (2015) 0.75

Pathology-confirmed cerebral arterial invasion and recurrent multiple brain metastasis from cardiac myxoma without evidence of disease after surgery and radiotherapy. Clin Neuropathol (2016) 0.75

Monthly ibandronate versus weekly risedronate treatment for low bone mineral density in stable renal transplant patients. Nucl Med Commun (2015) 0.75