Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer.

PubWeight™: 1.03‹?› | Rank: Top 15%

🔗 View Article (PMID 25349307)

Published in Mol Cancer Ther on October 27, 2014

Authors

Tatsushi Kodama1, Toshiyuki Tsukaguchi1, Yasuko Satoh1, Miyuki Yoshida1, Yoshiaki Watanabe1, Osamu Kondoh1, Hiroshi Sakamoto2

Author Affiliations

1: Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Japan.
2: Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Japan. sakamotohrs@chugai-pharm.co.jp.

Articles citing this

Lung Master Protocol (Lung-MAP)-A Biomarker-Driven Protocol for Accelerating Development of Therapies for Squamous Cell Lung Cancer: SWOG S1400. Clin Cancer Res (2015) 1.35

Cabozantinib in patients with advanced RET-rearranged non-small-cell lung cancer: an open-label, single-centre, phase 2, single-arm trial. Lancet Oncol (2016) 1.01

Targeted Therapies in Non-Small Cell Lung Cancer-Beyond EGFR and ALK. Cancers (Basel) (2015) 0.93

Mechanisms of Acquired Resistance to ALK Inhibitors and the Rationale for Treating ALK-positive Lung Cancer. Cancers (Basel) (2015) 0.90

Decoding Tumor Phenotypes for ALK, ROS1, and RET Fusions in Lung Adenocarcinoma Using a Radiomics Approach. Medicine (Baltimore) (2015) 0.83

Targeted therapies and immunotherapy in non-small-cell lung cancer. Ecancermedicalscience (2016) 0.82

Insights into brain metastasis in patients with ALK+ lung cancer: is the brain truly a sanctuary? Cancer Metastasis Rev (2015) 0.82

Visualizing spatial distribution of alectinib in murine brain using quantitative mass spectrometry imaging. Sci Rep (2016) 0.79

Crizotinib-Induced Abnormal Signal Processing in the Retina. PLoS One (2015) 0.77

Alectinib in RET-rearranged non-small cell lung cancer-Another progress in precision medicine? Transl Lung Cancer Res (2015) 0.76

TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors. Oncotarget (2016) 0.76

The RET fusion gene and its correlation with demographic and clinicopathological features of non-small cell lung cancer: a meta-analysis. Cancer Biol Ther (2015) 0.75

Targeted Lung Cancer Treatments and Eye Metastasis. Med Hypothesis Discov Innov Ophthalmol (2017) 0.75

Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade. F1000Res (2016) 0.75

Comprehensive Genomic Profiling of Clinically Advanced Medullary Thyroid Carcinoma. Oncology (2016) 0.75

Alterations in genes other than EGFR/ALK/ROS1 in non-small cell lung cancer: trials and treatment options. Cancer Biol Med (2016) 0.75

KRAS and the Reality of Personalized Medicine in Non-small Cell Lung Cancer. Mol Med (2016) 0.75

Resistance to RET-inhibition in RET-rearranged NSCLC is mediated by reactivation of RAS/MAPK signaling. Mol Cancer Ther (2017) 0.75

The molecular basis for RET tyrosine-kinase inhibitors in thyroid cancer. Best Pract Res Clin Endocrinol Metab (2017) 0.75