Mechanisms of Acquired Resistance to ALK Inhibitors and the Rationale for Treating ALK-positive Lung Cancer.

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Published in Cancers (Basel) on April 30, 2015

Authors

Hideko Isozaki1, Nagio Takigawa2, Katsuyuki Kiura3

Author Affiliations

1: Department of Clinical Pharmaceutics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan. h.isozaki325@gmail.com.
2: Department of General Internal Medicine 4, Kawasaki Medical School, Okayama 700-8505, Japan. ntakigaw@gmail.com.
3: Department of Allergy and Respiratory Medicine, Okayama University Hospital, Okayama 700-8558, Japan. kkiura@md.okayama-u.ac.jp.

Associated clinical trials:

A Phase 1/2 Study of the Oral ALK/EGFR Inhibitor AP26113 | NCT01449461

A Study Of PF-06463922 An ALK/ROS1 Inhibitor In Patients With Advanced Non Small Cell Lung Cancer With Specific Molecular Alterations | NCT01970865

A Clinical Study Testing The Safety and Efficacy of CH5424802/RO5424802 in Patients With ALK Positive Non-Small Cell Lung Cancer | NCT01588028

Phase 1/2 Study of X-396, an Oral ALK Inhibitor, in Patients With ALK-positive Non-Small Cell Lung Cancer | NCT01625234

Study of Oral RXDX-101 in Adult Patients With Locally Advanced or Metastatic Cancer Targeting NTRK1, NTRK2, NTRK3, ROS1, or ALK Molecular Alterations. (STARTRK-1) | NCT02097810

A Phase I/IIa Open-Label, Dose Escalation and Cohort Expansion Trial of Oral TSR-011 in Patients With Advanced Solid Tumors and Lymphomas | NCT02048488

Study of an Investigational Drug, ASP3026, in Patients With Solid Tumors | NCT01401504

To Determine the Maximum Tolerated Dose of Oral CEP-37440 in Patients With Advanced or Metastatic Solid Tumors | NCT01922752

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