One small step for a yeast--microevolution within macrophages renders Candida glabrata hypervirulent due to a single point mutation.

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Published in PLoS Pathog on October 30, 2014

Authors

Sascha Brunke1, Katja Seider2, Daniel Fischer2, Ilse D Jacobsen2, Lydia Kasper2, Nadja Jablonowski2, Anja Wartenberg2, Oliver Bader3, Adela Enache-Angoulvant4, Martin Schaller5, Christophe d'Enfert6, Bernhard Hube7

Author Affiliations

1: Integrated Research and Treatment Center, Sepsis und Sepsisfolgen, Center for Sepsis Control and Care (CSCC), Universitätsklinikum Jena, Jena, Germany; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute Jena (HKI), Jena, Germany.
2: Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute Jena (HKI), Jena, Germany.
3: Institute for Medical Microbiology and German National Reference Centre for Systemic Mycoses, University Medical Centre Göttingen, Göttingen, Germany.
4: APHP, Hôpital Bicêtre, Service de Bactériologie-Virologie-Parasitologie, Laboratoire de Parasitologie-Mycologie, Kremlin-Bicêtre, France.
5: Department of Dermatology, Eberhard-Karls-University, Tübingen, Germany.
6: Institut Pasteur, Unité Biologie et Pathogénicité Fongiques, Département Génomes et Génétique, Paris, France; INRA, USC2019, Paris, France.
7: Integrated Research and Treatment Center, Sepsis und Sepsisfolgen, Center for Sepsis Control and Care (CSCC), Universitätsklinikum Jena, Jena, Germany; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute Jena (HKI), Jena, Germany; Friedrich Schiller University, Jena, Germany.

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