Candida glabrata persistence in mice does not depend on host immunosuppression and is unaffected by fungal amino acid auxotrophy.

PubWeight™: 1.10‹?› | Rank: Top 10%

🔗 View Article (PMC 2825948)

Published in Infect Immun on December 14, 2009

Authors

I D Jacobsen1, S Brunke, K Seider, T Schwarzmüller, A Firon, C d'Enfért, K Kuchler, B Hube

Author Affiliations

1: Department for Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, 07745 Jena, Germany.

Articles citing this

Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes. PLoS Pathog (2014) 1.98

Two unlike cousins: Candida albicans and C. glabrata infection strategies. Cell Microbiol (2013) 1.19

Hosting infection: experimental models to assay Candida virulence. Int J Microbiol (2011) 1.14

Contribution of CgPDR1-regulated genes in enhanced virulence of azole-resistant Candida glabrata. PLoS One (2011) 1.13

The potential impact of antifungal drug resistance mechanisms on the host immune response to Candida. Virulence (2012) 1.03

Thriving within the host: Candida spp. interactions with phagocytic cells. Med Microbiol Immunol (2013) 1.02

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance. Nat Commun (2016) 1.02

Modulation of phagosomal pH by Candida albicans promotes hyphal morphogenesis and requires Stp2p, a regulator of amino acid transport. PLoS Pathog (2014) 0.99

Defining the transcriptomic landscape of Candida glabrata by RNA-Seq. Nucleic Acids Res (2015) 0.97

Galleria mellonella as a model host to study virulence of Candida. Virulence (2014) 0.93

Gain-of-function mutations in PDR1, a regulator of antifungal drug resistance in Candida glabrata, control adherence to host cells. Infect Immun (2013) 0.92

Pathogenesis of Candida albicans infections in the alternative chorio-allantoic membrane chicken embryo model resembles systemic murine infections. PLoS One (2011) 0.88

One small step for a yeast--microevolution within macrophages renders Candida glabrata hypervirulent due to a single point mutation. PLoS Pathog (2014) 0.87

Of mice, flies--and men? Comparing fungal infection models for large-scale screening efforts. Dis Model Mech (2015) 0.86

Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages. Eukaryot Cell (2013) 0.85

Candida glabrata intra-abdominal candidiasis is characterized by persistence within the peritoneal cavity and abscesses. Infect Immun (2014) 0.84

Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages. PLoS One (2014) 0.84

Histidine biosynthesis plays a crucial role in metal homeostasis and virulence of Aspergillus fumigatus. Virulence (2016) 0.83

Candida glabrata susceptibility to antifungals and phagocytosis is modulated by acetate. Front Microbiol (2015) 0.82

Genome engineering in the yeast pathogen Candida glabrata using the CRISPR-Cas9 system. Sci Rep (2016) 0.80

Heteroresistance to Fluconazole Is a Continuously Distributed Phenotype among Candida glabrata Clinical Strains Associated with In Vivo Persistence. MBio (2016) 0.79

Investigation of the function of Candida albicans Als3 by heterologous expression in Candida glabrata. Infect Immun (2013) 0.79

Candida glabrata: new tools and technologies-expanding the toolkit. FEMS Yeast Res (2015) 0.78

Opportunistic fungal pathogen Candida glabrata circulates between humans and yellow-legged gulls. Sci Rep (2016) 0.76

First human model of in vitro Candida albicans persistence within granuloma for the reliable study of host-fungi interactions. PLoS One (2012) 0.76

Upregulation of the Adhesin Gene EPA1 Mediated by PDR1 in Candida glabrata Leads to Enhanced Host Colonization. mSphere (2016) 0.75

A feast for Candida: Metabolic plasticity confers an edge for virulence. PLoS Pathog (2017) 0.75

Functional analysis of selected deletion mutants in Candida glabrata under hypoxia. 3 Biotech (2017) 0.75

Articles cited by this

Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev (2007) 15.66

Myeloperoxidase: friend and foe. J Leukoc Biol (2005) 7.16

Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology (1984) 6.17

Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans. Clin Microbiol Rev (1999) 5.84

The SAT1 flipper, an optimized tool for gene disruption in Candida albicans. Gene (2004) 5.79

Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions. Nat Genet (2007) 4.59

Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans. Eukaryot Cell (2005) 4.36

The p47phox mouse knock-out model of chronic granulomatous disease. J Exp Med (1995) 4.25

Nosocomial fungal infections: epidemiology, diagnosis, and treatment. Med Mycol (2007) 3.02

Pathogenicity of Candida albicans auxotrophic mutants in experimental infections. Infect Immun (1991) 2.91

The changing epidemiology of invasive candidiasis: Candida glabrata and Candida krusei as the leading causes of candidemia in hematologic malignancy. Cancer (2008) 2.57

Mice with disseminated candidiasis die of progressive sepsis. J Infect Dis (2005) 2.42

A family of glycosylphosphatidylinositol-linked aspartyl proteases is required for virulence of Candida glabrata. Proc Natl Acad Sci U S A (2007) 1.93

Comparison of pathogenesis and host immune responses to Candida glabrata and Candida albicans in systemically infected immunocompetent mice. Infect Immun (2001) 1.75

Candida albicans Pmr1p, a secretory pathway P-type Ca2+/Mn2+-ATPase, is required for glycosylation and virulence. J Biol Chem (2005) 1.70

Candida glabrata fungemia: experience in a tertiary care center. Clin Infect Dis (2005) 1.68

Candidemia in patients with hematologic malignancies in the era of new antifungal agents (2001-2007): stable incidence but changing epidemiology of a still frequently lethal infection. Cancer (2009) 1.68

Attenuated virulence of uridine-uracil auxotrophs of Aspergillus fumigatus. Infect Immun (1996) 1.60

Infrared body temperature measurement of mice as an early predictor of death in experimental fungal infections. Lab Anim (2003) 1.53

URA3 as a selectable marker for disruption and virulence assessment of Candida albicans genes. Trends Microbiol (2003) 1.52

Candidemia in nonneutropenic critically ill patients: risk factors for non-albicans Candida spp. Crit Care Med (2008) 1.50

In vivo pathogenicity of eight medically relevant Candida species in an animal model. Infection (2002) 1.48

Development of Saccharomyces cerevisiae as a model pathogen. A system for the genetic identification of gene products required for survival in the mammalian host environment. Genetics (2001) 1.46

Comparative pathogenicity of auxotrophic mutants of Candida albicans. Can J Microbiol (1984) 1.39

Development, differentiation, and phenotypic heterogeneity of murine tissue macrophages. J Leukoc Biol (1996) 1.37

Ura-status-dependent adhesion of Candida albicans mutants. FEMS Microbiol Lett (2001) 1.36

Early-expressed chemokines predict kidney immunopathology in experimental disseminated Candida albicans infections. PLoS One (2009) 1.31

Role of granulocyte macrophage colony-stimulating factor in host defense against pulmonary Cryptococcus neoformans infection during murine allergic bronchopulmonary mycosis. Am J Pathol (2007) 1.31

Infection of human oral epithelia with Candida species induces cytokine expression correlated to the degree of virulence. J Invest Dermatol (2002) 1.27

Germ tubes and proteinase activity contribute to virulence of Candida albicans in murine peritonitis. Infect Immun (1999) 1.22

Comparison of fluconazole, amphotericin B and flucytosine in treatment of a murine model of disseminated infection with Candida glabrata in immunocompromised mice. J Antimicrob Chemother (1995) 1.10

Efficacies of fluconazole, caspofungin, and amphotericin B in Candida glabrata-infected p47phox-/- knockout mice. Antimicrob Agents Chemother (2002) 1.07

Determinants of mortality in non-neutropenic ICU patients with candidaemia. Crit Care (2009) 1.06

Effects of dosing regimen on accumulation, retention and prophylactic efficacy of liposomal amphotericin B. J Antimicrob Chemother (2007) 1.05

Massive induction of innate immune response to Candida albicans in the kidney in a murine intravenous challenge model. FEMS Yeast Res (2009) 1.04

The predictors of outcome in immunocompetent patients with hematogenous candidiasis. Int J Infect Dis (2004) 1.03

Comparison of the fungicidal activities of caspofungin and amphotericin B against Candida glabrata. Antimicrob Agents Chemother (2005) 1.00

Epithelial GM-CSF induction by Candida glabrata. J Dent Res (2009) 0.98

Complement C3 plays an essential role in the control of opportunistic fungal infections. Infect Immun (2009) 0.96

Cytotoxic and cytokine-inducing properties of Candida glabrata in single and mixed oral infection models. Microb Pathog (2007) 0.93

Vaccination of corticosteroid immunosuppressed mice against invasive pulmonary aspergillosis. J Infect Dis (2002) 0.86

Intranasal granulocyte-macrophage colony-stimulating factor reduces the Aspergillus burden in an immunosuppressed murine model of pulmonary aspergillosis. Antimicrob Agents Chemother (2007) 0.86

Dark brown is the more virulent of the switch phenotypes of Candida glabrata. Microbiology (2008) 0.85

Quantification of bovine neutrophil migration across mammary epithelium in vitro. Can J Vet Res (1996) 0.82

Efficacy of a new formulation of amphotericin B in a murine model of disseminated infection by Candida glabrata. J Antimicrob Chemother (2008) 0.79

Protection of peritoneal macrophages by granulocyte/macrophage colony-stimulating factor (GM-CSF) against dexamethasone suppression of killing of Aspergillus, and the effect of human GM-CSF. Microbes Infect (2002) 0.77

Articles by these authors

Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob Agents Chemother (1995) 7.44

Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J Biol Chem (1994) 2.45

A triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence. Infect Immun (1997) 2.35

Multiplicity of genes encoding secreted aspartic proteinases in Candida species. Mol Microbiol (1994) 2.09

The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole. FEBS Lett (1996) 1.93

The pdr12 ABC transporter is required for the development of weak organic acid resistance in yeast. EMBO J (1998) 1.83

Subcellular and submitochondrial localization of phospholipid-synthesizing enzymes in Saccharomyces cerevisiae. J Bacteriol (1986) 1.71

Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity. Mol Microbiol (1998) 1.70

Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis. Mol Microbiol (1999) 1.69

Identification of mouse histone deacetylase 1 as a growth factor-inducible gene. Mol Cell Biol (1997) 1.62

Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome. J Biol Chem (1998) 1.61

Evidence that members of the secretory aspartyl proteinase gene family, in particular SAP2, are virulence factors for Candida vaginitis. J Infect Dis (1999) 1.58

Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae. Mol Cell Biol (1995) 1.56

Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter. Mol Biol Cell (1998) 1.55

The Arabidopsis thaliana ABC transporter AtMRP5 controls root development and stomata movement. EMBO J (2001) 1.53

The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo. J Biol Chem (1996) 1.50

Systemic fungal infections caused by Candida species: epidemiology, infection process and virulence attributes. Curr Drug Targets (2005) 1.48

Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance. Biochim Biophys Acta (1999) 1.42

The Saccharomyces cerevisiae weak-acid-inducible ABC transporter Pdr12 transports fluorescein and preservative anions from the cytosol by an energy-dependent mechanism. J Bacteriol (1999) 1.42

Molecular analysis of CaMnt1p, a mannosyl transferase important for adhesion and virulence of Candida albicans. Proc Natl Acad Sci U S A (1998) 1.36

Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida albicans. Microbiology (1998) 1.35

Secreted aspartyl proteinases and interactions of Candida albicans with human endothelial cells. Infect Immun (1998) 1.31

Fungal ABC proteins: pleiotropic drug resistance, stress response and cellular detoxification. Res Microbiol (2001) 1.29

Intracellular location, complex formation, and function of the transporter associated with antigen processing in yeast. Eur J Biochem (1997) 1.28

Glucosylceramide synthases, a gene family responsible for the biosynthesis of glucosphingolipids in animals, plants, and fungi. J Biol Chem (2001) 1.28

CandidaDB: a genome database for Candida albicans pathogenomics. Nucleic Acids Res (2005) 1.23

The ATP-binding cassette multidrug transporter Snq2 of Saccharomyces cerevisiae: a novel target for the transcription factors Pdr1 and Pdr3. Mol Microbiol (1996) 1.22

Germ tubes and proteinase activity contribute to virulence of Candida albicans in murine peritonitis. Infect Immun (1999) 1.22

Human Dermo-1 has attributes similar to twist in early bone development. Bone (2000) 1.20

Cloning and functional expression of UGT genes encoding sterol glucosyltransferases from Saccharomyces cerevisiae, Candida albicans, Pichia pastoris, and Dictyostelium discoideum. J Biol Chem (1999) 1.17

Diazaborine resistance in the yeast Saccharomyces cerevisiae reveals a link between YAP1 and the pleiotropic drug resistance genes PDR1 and PDR3. J Biol Chem (1997) 1.17

The transmembrane domain 10 of the yeast Pdr5p ABC antifungal efflux pump determines both substrate specificity and inhibitor susceptibility. Mol Microbiol (2000) 1.13

The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators. FEBS Lett (1997) 1.12

Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3. J Cell Biol (1997) 1.12

Altered adherence in strains of Candida albicans harbouring null mutations in secreted aspartic proteinase genes. FEMS Microbiol Lett (1998) 1.11

Invasion of Candida albicans correlates with expression of secreted aspartic proteinases during experimental infection of human epidermis. J Invest Dermatol (2000) 1.07

Effects of the human immunodeficiency virus (HIV) proteinase inhibitors saquinavir and indinavir on in vitro activities of secreted aspartyl proteinases of Candida albicans isolates from HIV-infected patients. Antimicrob Agents Chemother (1999) 1.05

The genes encoding the secreted aspartyl proteinases of Candida albicans constitute a family with at least three members. Infect Immun (1993) 0.97

The KEX2 gene of Candida glabrata is required for cell surface integrity. Mol Microbiol (2001) 0.94

In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients. J Invest Dermatol (1999) 0.91

The hydrophilic and acidic N-terminus of the integral membrane enzyme phosphatidylserine synthase is required for efficient membrane insertion. Yeast (1990) 0.91

Game theoretical modelling of survival strategies of Candida albicans inside macrophages. J Theor Biol (2010) 0.89

Identification of mitochondrial and microsomal phosphatidylserine synthase in Saccharomyces cerevisiae as the gene product of the CHO1 structural gene. J Bacteriol (1988) 0.88

A method for recovery of Candida albicans DNA from larger blood samples and its detection by polymerase chain reaction on proteinase genes. Mycoses (1997) 0.88

In vitro investigations on the mode of action of the hydroxypyridone antimycotics rilopirox and piroctone on Candida albicans. Mycoses (2006) 0.82

Chicken lecithin-cholesterol acyltransferase. Molecular characterization reveals unusual structure and expression pattern. J Biol Chem (1995) 0.82

Positive and negative control of multidrug resistance by the Sit4 protein phosphatase in Kluyveromyces lactis. J Biol Chem (2000) 0.80

Loss of Cmk1 Ca(2+)-calmodulin-dependent protein kinase in yeast results in constitutive weak organic acid resistance, associated with a post-transcriptional activation of the Pdr12 ATP-binding cassette transporter. Mol Microbiol (2000) 0.80

Cmdr1, a chicken P-glycoprotein, confers multidrug resistance and interacts with estradiol. Biol Chem (1999) 0.80

Characterization of UDP-glucose:ceramide glucosyltransferases from different organisms. Biochem Soc Trans (2000) 0.80

[Extracellular hydrolytic enzymes and their relevance during Candida albicans infections]. Mycoses (2000) 0.78

A cDNA from brain of Xenopus laevis coding for a new precursor of thyrotropin-releasing hormone. FEBS Lett (1992) 0.77

Molecular biological and biochemical aspects of fungal dimorphism. J Med Vet Mycol (1994) 0.77

[Investigations on the regulation of secreted aspartyl proteases in a model of oral candidiasis in vivo]. Mycoses (1998) 0.77

The sensitivities of yeast strains deficient in PDR ABC transporters, to quinoline-ring antimalarial drugs. Ann Trop Med Parasitol (2004) 0.76

[Mode of action of ciclopiroxolamine on Candida albicans]. Mycoses (2002) 0.76

Analysis of differentially expressed genes associated with tryptophan-dependent pigment synthesis in M. furfur by cDNA subtraction technology. Med Mycol (2008) 0.75

[Reminiscences of Dr. Zdenĕk Stich]. Cas Lek Cesk (1982) 0.75

Retinol in avian oogenesis: molecular properties of the carrier protein. DNA Cell Biol (1995) 0.75

Cytostatic treatment. Scand J Rheumatol Suppl (1975) 0.75

A cDNA from brain of Xenopus laevis coding for a new precursor of thyrotropin-releasing hormone. FEBS Lett (1992) 0.75

Construction and characterization of single-transcript tricistronic retroviral vectors using two internal ribosome entry sites. Somat Cell Mol Genet (1998) 0.75

[Characterization of the interaction between Candida albicans and host cells: In vitro model using reconstituted human skin and mucosa]. Hautarzt (2008) 0.75