Published in J Biol Chem on January 15, 1989
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Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBO J (1990) 3.27
Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization. Proc Natl Acad Sci U S A (1991) 2.53
The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J Cell Biol (1990) 2.36
Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide. EMBO J (2005) 2.12
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Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect. EMBO J (1996) 1.70
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Generation and characterization of urokinase receptor-deficient mice. J Clin Invest (1996) 1.54
The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent. J Cell Biol (1994) 1.52
A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity. EMBO J (1997) 1.47
In vivo paracrine interaction between urokinase and its receptor: effect on tumor cell invasion. J Cell Biol (1991) 1.33
The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells. J Clin Invest (1996) 1.31
High-affinity urokinase receptor antagonists identified with bacteriophage peptide display. Proc Natl Acad Sci U S A (1994) 1.26
Two alternatively spliced mouse urokinase receptor mRNAs with different histological localization in the gastrointestinal tract. J Cell Biol (1991) 1.23
An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration. Mol Biol Cell (2005) 1.15
Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. J Biol Chem (2010) 1.14
Transcriptional and post-transcriptional regulation of the receptor for urokinase-type plasminogen activator by cytokines and tumour promoters in the human lung carcinoma cell line A549. Biochem J (1995) 1.11
Metastatic behavior of human melanoma cell lines in nude mice correlates with urokinase-type plasminogen activator, its type-1 inhibitor, and urokinase-mediated matrix degradation. J Cell Biol (1991) 1.10
Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression. J Clin Invest (1995) 1.08
The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice. Am J Pathol (2009) 1.07
Lysosomal degradation of receptor-bound urokinase-type plasminogen activator is enhanced by its inhibitors in human trophoblastic choriocarcinoma cells. Cell Regul (1990) 1.06
Expression of the urokinase receptor in vascular endothelial cells is stimulated by basic fibroblast growth factor. J Cell Biol (1991) 1.06
Receptor-independent role of urokinase-type plasminogen activator in pericellular plasmin and matrix metalloproteinase proteolysis during vascular wound healing in mice. J Cell Biol (1998) 1.03
Complementation between urokinase-producing and receptor-producing cells in extracellular matrix degradation. Cell Regul (1991) 1.03
Regulation of plasminogen receptor expression on human monocytes and monocytoid cell lines. J Cell Biol (1990) 0.99
A high-affinity receptor for urokinase plasminogen activator on human keratinocytes: characterization and potential modulation during migration. Cell Regul (1990) 0.99
Urokinase-receptor biosynthesis, mRNA level and gene transcription are increased by transforming growth factor beta 1 in human A549 lung carcinoma cells. EMBO J (1991) 0.99
A ligand-free, soluble urokinase receptor is present in the ascitic fluid from patients with ovarian cancer. J Clin Invest (1993) 0.94
Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor. BMC Gastroenterol (2006) 0.91
Inhibition of establishment of primary and micrometastatic tumors by a urokinase plasminogen activator receptor antagonist. Clin Exp Metastasis (1998) 0.89
A peptide inhibitor of the urokinase/urokinase receptor system inhibits alteration of the blood-retinal barrier in diabetes. FASEB J (2008) 0.89
Urokinase-type plasminogen activator inhibits efferocytosis of neutrophils. Am J Respir Crit Care Med (2010) 0.88
Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia. J Clin Invest (2000) 0.87
A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen. Cell Signal (2012) 0.84
The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release. J Biol Chem (2011) 0.83
Assignment of the urokinase-type plasminogen activator receptor gene (PLAUR) to chromosome 19q13.1-q13.2. Am J Hum Genet (1992) 0.82
A cleavage-resistant urokinase plasminogen activator receptor exhibits dysregulated cell-surface clearance. J Biol Chem (2010) 0.81
Plasmin overcomes resistance to prostaglandin E2 in fibrotic lung fibroblasts by reorganizing protein kinase A signaling. J Biol Chem (2011) 0.81
Saturation of tumour cell surface receptors for urokinase-type plasminogen activator by amino-terminal fragment and subsequent effect on reconstituted basement membranes invasion. Br J Cancer (1993) 0.79
The plasminogen receptor, Plg-R(KT), and macrophage function. J Biomed Biotechnol (2012) 0.78
Constriction of carotid arteries by urokinase-type plasminogen activator requires catalytic activity and is independent of NH(2)-terminal domains. Thromb Haemost (2009) 0.78
Plasminogen receptors on rat colon carcinoma cells. Br J Cancer (1992) 0.77
The plasminogen activation system and the regulation of catecholaminergic function. J Biomed Biotechnol (2012) 0.76
Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2. Am J Physiol Heart Circ Physiol (2013) 0.76
Decreased urokinase receptor expression by overexpression of the plasminogen activator in a colon cancer cell line. Biochem J (1992) 0.75
Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J Bacteriol (1995) 46.37
A pSC101-derived plasmid which shows no sequence homology to other commonly used cloning vectors. Gene (1984) 9.45
Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors. J Exp Med (1986) 5.09
The plasminogen activator/plasmin system. J Clin Invest (1991) 4.20
The 3' untranslated region of messenger RNA: A molecular 'hotspot' for pathology? Nat Med (2000) 4.11
A pathway for disulfide bond formation in vivo. Proc Natl Acad Sci U S A (1993) 3.86
A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase. J Cell Biol (1985) 3.62
Basic fibroblast growth factor induces angiogenesis in vitro. Proc Natl Acad Sci U S A (1986) 3.42
Macrophage plasminogen activator: modulation of enzyme production by anti-inflammatory steroids, mitotic inhibitors, and cyclic nucleotides. Cell (1976) 3.13
An in vivo pathway for disulfide bond isomerization in Escherichia coli. Proc Natl Acad Sci U S A (1996) 2.98
Regulation of Escherichia coli cell envelope proteins involved in protein folding and degradation by the Cpx two-component system. Genes Dev (1997) 2.96
Concomitant secretion of prourokinase and of a plasminogen activator-specific inhibitor by cultured human monocytes-macrophages. J Exp Med (1984) 2.78
Mutations that allow disulfide bond formation in the cytoplasm of Escherichia coli. Science (1993) 2.73
Direct identification of prohormone conversion site in insulin-secreting cells. Cell (1985) 2.64
Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors. J Cell Biol (1987) 2.63
Secretion of plasminogen activator by human polymorphonuclear leukocytes. Modulation by glucocorticoids and other effectors. J Exp Med (1977) 2.60
Macrophage plasminogen activator: induction by concanavalin A and phorbol myristate acetate. Cell (1977) 2.47
The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J Cell Biol (1990) 2.36
Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles. Cell (1987) 2.33
Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. Development (1991) 2.28
Temperature-sensitive mutation in the initiation codon of the rIIB gene of bacteriophage T4. Proc Natl Acad Sci U S A (1979) 2.18
Cloning, nucleotide sequencing and expression of cDNAs encoding mouse urokinase-type plasminogen activator. Eur J Biochem (1985) 2.14
Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles. J Cell Biol (1986) 2.06
Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro. J Cell Biol (1990) 2.00
Macrophage plasminogen activator: induction by products of activated lymphoid cells. J Exp Med (1977) 2.00
A clathrin-coated, Golgi-related compartment of the insulin secreting cell accumulates proinsulin in the presence of monensin. Cell (1984) 1.99
Extracellular proteolysis in the adult murine brain. J Clin Invest (1993) 1.96
Regulated polyadenylation controls mRNA translation during meiotic maturation of mouse oocytes. Genes Dev (1989) 1.95
Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos. J Cell Biol (1989) 1.88
Transient translational silencing by reversible mRNA deadenylation. Cell (1992) 1.88
Expression of the endogenous type II secretion pathway in Escherichia coli leads to chitinase secretion. EMBO J (2000) 1.82
Meiotic maturation of mouse oocytes triggers the translation and polyadenylation of dormant tissue-type plasminogen activator mRNA. Genes Dev (1987) 1.74
Amiloride selectively inhibits the urokinase-type plasminogen activator. FEBS Lett (1987) 1.66
Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice. EMBO J (1999) 1.66
Antisense RNA directed against the 3' noncoding region prevents dormant mRNA activation in mouse oocytes. Science (1988) 1.63
Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids. J Exp Med (1976) 1.60
Specific protease deficiency in polymorphonuclear leukocytes of Chédiak-Higashi syndrome and beige mice. J Exp Med (1978) 1.60
Sites of synthesis of urokinase and tissue-type plasminogen activators in the murine kidney. J Clin Invest (1991) 1.59
Purification of murine T cell growth factor. A lymphocyte mitogen with helper activity. J Exp Med (1981) 1.57
Smooth muscle cells express urokinase during mitogenesis and tissue-type plasminogen activator during migration in injured rat carotid artery. Circ Res (1990) 1.54
TGF-beta 1 influences the relative development of the exocrine and endocrine pancreas in vitro. Development (1994) 1.51
The production of distinct forms of plasminogen activator by mouse embryonic cells. Dev Biol (1982) 1.48
Isolation and characterization of urokinase from human plasma. J Biol Chem (1982) 1.47
Processing of unstable bacteriophage T4 gene 32 mRNAs into a stable species requires Escherichia coli ribonuclease E. EMBO J (1988) 1.47
Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes. J Exp Med (1992) 1.46
Biphasic effect of transforming growth factor-beta 1 on in vitro angiogenesis. Exp Cell Res (1993) 1.45
Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes. Proc Natl Acad Sci U S A (1994) 1.43
The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants. J Biol Chem (1990) 1.43
Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug. Proc Natl Acad Sci U S A (1997) 1.38
Facultative polypeptide translocation allows a single mRNA to encode the secreted and cytosolic forms of plasminogen activators inhibitor 2. EMBO J (1989) 1.38
Modulations of functional activity in differentiated macrophages are accompanied by early and transient increase or decrease in c-fos gene transcription. J Immunol (1987) 1.38
Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension. J Clin Invest (1997) 1.37
Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells. J Cell Biol (1987) 1.35
Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells. J Biol Chem (1995) 1.34
Purification and characterization of a plasminogen activator inhibitor from the histiocytic lymphoma cell line U-937. J Biol Chem (1986) 1.33
Plasminogen activator and mouse spermatozoa: urokinase synthesis in the male genital tract and binding of the enzyme to the sperm cell surface. J Cell Biol (1987) 1.33
Actin isoform synthesis and mRNA levels in quiescent and proliferating rat aortic smooth muscle cells in vivo and in vitro. Lab Invest (1986) 1.33
Plasminogen activators and their inhibitors in a human mammary cell line (HBL-100). Modulation by glucocorticoids. J Biol Chem (1986) 1.32
Phorbol ester induces the biosynthesis of glycosylated and nonglycosylated plasminogen activator inhibitor 2 in high excess over urokinase-type plasminogen activator in human U-937 lymphoma cells. J Cell Biol (1987) 1.32
RNA and protein synthesis in human peripheral blood polymorphonuclear leukocytes. J Exp Med (1979) 1.30
Increase of urokinase-type plasminogen activator gene expression in human lung and breast carcinomas. Cancer Res (1987) 1.29
Plasminogen activator in mouse and rat oocytes: induction during meiotic maturation. Cell (1985) 1.29
Masking, unmasking, and regulated polyadenylation cooperate in the translational control of a dormant mRNA in mouse oocytes. Genes Dev (1998) 1.26
Plasminogen activator inhibitor-1 in acute hyperoxic mouse lung injury. J Clin Invest (1996) 1.25
Plasminogen activator-specific inhibitors produced by human monocytes/macrophages. J Exp Med (1987) 1.24
TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes. Biochem Biophys Res Commun (1995) 1.23
c-fos gene transcription in murine macrophages is modulated by a calcium-dependent block to elongation in intron 1. Mol Cell Biol (1991) 1.20
A two-step recognition of signal sequences determines the translocation efficiency of proteins. EMBO J (1996) 1.19
Upregulation of urokinase receptor expression on migrating endothelial cells. J Cell Biol (1993) 1.18
The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. Eur J Biochem (1996) 1.16
Human clusterin gene expression is confined to surviving cells during in vitro programmed cell death. J Clin Invest (1994) 1.16
Mouse L cells expressing human prourokinase-type plasminogen activator: effects on extracellular matrix degradation and invasion. J Cell Biol (1989) 1.14