Published in PLoS Pathog on November 06, 2014
Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex. PLoS Pathog (2016) 1.40
Identification and Characterization of a Novel Aspergillus fumigatus Rhomboid Family Putative Protease, RbdA, Involved in Hypoxia Sensing and Virulence. Infect Immun (2016) 0.84
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Insights into the cellular responses to hypoxia in filamentous fungi. Curr Genet (2015) 0.78
A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions. PLoS Pathog (2017) 0.77
Characterization of the Paracoccidioides Hypoxia Response Reveals New Insights into Pathogenesis Mechanisms of This Important Human Pathogenic Fungus. PLoS Negl Trop Dis (2015) 0.77
RNAseq analysis of Aspergillus fumigatus in blood reveals a just wait and see resting stage behavior. BMC Genomics (2015) 0.77
Functional Analysis of Sterol Transporter Orthologues in the Filamentous Fungus Aspergillus nidulans. Eukaryot Cell (2015) 0.77
The Aspergillus fumigatus CrzA Transcription Factor Activates Chitin Synthase Gene Expression during the Caspofungin Paradoxical Effect. MBio (2017) 0.77
Suppressing Farnesyl Diphosphate Synthase Alters Chloroplast Development and Triggers Sterol-Dependent Induction of Jasmonate- and Fe-Related Responses. Plant Physiol (2016) 0.76
Systems Biology Approaches for Host-Fungal Interactions: An Expanding Multi-Omics Frontier. OMICS (2016) 0.76
Differences in Host Innate Responses among Coccidioides Isolates in a Murine Model of Pulmonary Coccidioidomycosis. Eukaryot Cell (2015) 0.75
Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison. Front Cell Infect Microbiol (2016) 0.75
Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression. PLoS Pathog (2017) 0.75
Regulation of Sterol Biosynthesis in the Human Fungal Pathogen Aspergillus fumigatus: Opportunities for Therapeutic Development. Front Microbiol (2017) 0.75
Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor. Sci Rep (2016) 0.75
Sensitisation of an Azole-Resistant Aspergillus fumigatus Strain containing the Cyp51A-Related Mutation by Deleting the SrbA Gene. Sci Rep (2016) 0.75
Novel Approaches for Fungal Transcriptomics from Host Samples. Front Microbiol (2016) 0.75
New advances in invasive aspergillosis immunobiology leading the way towards personalized therapeutic approaches. Cytokine (2016) 0.75
Deciphering the Regulatory Network between the SREBP Pathway and Protein Secretion in Neurospora crassa. MBio (2017) 0.75
Aspergillus fumigatus morphology and dynamic host interactions. Nat Rev Microbiol (2017) 0.75
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Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes. PLoS Genet (2008) 2.34
Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment. Cancer Metastasis Rev (2007) 2.15
Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast. Mol Cell Biol (2006) 2.11
A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus. PLoS Pathog (2008) 2.09
A link between virulence and homeostatic responses to hypoxia during infection by the human fungal pathogen Cryptococcus neoformans. PLoS Pathog (2007) 1.94
Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans. Mol Microbiol (2007) 1.93
SreA-mediated iron regulation in Aspergillus fumigatus. Mol Microbiol (2008) 1.85
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Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Biochem Soc Trans (2002) 1.82
Multiplexed measurements of gene signatures in different analytes using the Nanostring nCounter Assay System. BMC Res Notes (2009) 1.80
Expanding roles for SREBP in metabolism. Cell Metab (2012) 1.76
Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member. EMBO J (2008) 1.61
In vivo hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis. PLoS Pathog (2011) 1.60
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Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy. Cell Metab (2011) 1.50
Sterol regulatory element binding proteins in fungi: hypoxic transcription factors linked to pathogenesis. Eukaryot Cell (2010) 1.49
Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif. Proc Natl Acad Sci U S A (2009) 1.46
SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus. PLoS Genet (2011) 1.46
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Time course global gene expression analysis of an in vivo Candida biofilm. J Infect Dis (2009) 1.39
Functional characterization of the Aspergillus fumigatus CRZ1 homologue, CrzA. Mol Microbiol (2008) 1.35
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A role for sterol levels in oxygen sensing in Saccharomyces cerevisiae. Genetics (2006) 1.32
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A mechanism of oxygen sensing in yeast. Multiple oxygen-responsive steps in the heme biosynthetic pathway affect Hap1 activity. J Biol Chem (2003) 1.21
Enemy of the (immunosuppressed) state: an update on the pathogenesis of Aspergillus fumigatus infection. Br J Haematol (2010) 1.21
Responses to hypoxia in fungal pathogens. Cell Microbiol (2008) 1.18
Hypoxia and fungal pathogenesis: to air or not to air? Eukaryot Cell (2012) 1.18
Candida albicans commensalism and pathogenicity are intertwined traits directed by a tightly knit transcriptional regulatory circuit. PLoS Biol (2013) 1.18
Bioluminescent Aspergillus fumigatus, a new tool for drug efficiency testing and in vivo monitoring of invasive aspergillosis. Appl Environ Microbiol (2008) 1.16
FungiFun: a web-based application for functional categorization of fungal genes and proteins. Fungal Genet Biol (2010) 1.15
Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter. BMC Genomics (2012) 1.11
Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. J Biol Chem (2011) 1.07
Degradation of sterol regulatory element-binding protein precursor requires the endoplasmic reticulum-associated degradation components Ubc7 and Hrd1 in fission yeast. J Biol Chem (2009) 1.07
Aspergillus fumigatus metabolism: clues to mechanisms of in vivo fungal growth and virulence. Med Mycol (2009) 1.06
Mapping yeast transcriptional networks. Genetics (2013) 1.06
Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi? Med Mycol (2010) 1.04
Dsc orthologs are required for hypoxia adaptation, triazole drug responses, and fungal virulence in Aspergillus fumigatus. Eukaryot Cell (2012) 1.01
Conservation of the sterol regulatory element-binding protein pathway and its pathobiological importance in Cryptococcus neoformans. Eukaryot Cell (2009) 0.98
The hypoxia-inflammation link and potential drug targets. Curr Opin Anaesthesiol (2011) 0.97
The small GTPase RacA mediates intracellular reactive oxygen species production, polarized growth, and virulence in the human fungal pathogen Aspergillus fumigatus. Eukaryot Cell (2010) 0.97
Ergosterol regulates sterol regulatory element binding protein (SREBP) cleavage in fission yeast. J Biol Chem (2010) 0.96
SclR, a basic helix-loop-helix transcription factor, regulates hyphal morphology and promotes sclerotial formation in Aspergillus oryzae. Eukaryot Cell (2011) 0.96
Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach. BMC Syst Biol (2012) 0.96
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Subunit architecture of the Golgi Dsc E3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. J Biol Chem (2013) 0.86
Modeling the transcriptional regulatory network that controls the early hypoxic response in Candida albicans. Eukaryot Cell (2014) 0.85
Two C4-sterol methyl oxidases (Erg25) catalyse ergosterol intermediate demethylation and impact environmental stress adaptation in Aspergillus fumigatus. Microbiology (2014) 0.84
Are we there yet? Recent progress in the molecular diagnosis and novel antifungal targeting of Aspergillus fumigatus and invasive aspergillosis. PLoS Pathog (2013) 0.83
A comprehensive functional portrait of two heat shock factor-type transcriptional regulators involved in Candida albicans morphogenesis and virulence. PLoS Pathog (2013) 0.82
Functional analysis and subcellular location of two flavohemoglobins from Aspergillus oryzae. Fungal Genet Biol (2010) 0.82
Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation. Mol Biol Cell (2012) 0.82
Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. J Biol Chem (2013) 0.78
Aspergillus fumigatus invasion increases with progressive airway ischemia. PLoS One (2013) 0.78
Large-scale transcriptional response to hypoxia in Aspergillus fumigatus observed using RNAseq identifies a novel hypoxia regulated ncRNA. Mycopathologia (2014) 0.77
Spatial distribution and function of sterol regulatory element-binding protein 1a and 2 homo- and heterodimers by in vivo two-photon imaging and spectroscopy fluorescence resonance energy transfer. Mol Cell Biol (2005) 0.76
Activation and alliance of regulatory pathways in C. albicans during mammalian infection. PLoS Biol (2015) 1.14
Myeloid derived hypoxia inducible factor 1-alpha is required for protection against pulmonary Aspergillus fumigatus infection. PLoS Pathog (2014) 0.93
The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess. EMBO J (2014) 0.91
Crucial role for neuronal nitric oxide synthase in early microcirculatory derangement and recipient survival following murine pancreas transplantation. PLoS One (2014) 0.79
Loregic: a method to characterize the cooperative logic of regulatory factors. PLoS Comput Biol (2015) 0.77
Characterization of the Paracoccidioides Hypoxia Response Reveals New Insights into Pathogenesis Mechanisms of This Important Human Pathogenic Fungus. PLoS Negl Trop Dis (2015) 0.77
Bypass of Candida albicans Filamentation/Biofilm Regulators through Diminished Expression of Protein Kinase Cak1. PLoS Genet (2016) 0.77
Promiscuous signaling by a regulatory system unique to the pandemic PMEN1 pneumococcal lineage. PLoS Pathog (2017) 0.76
Location, location, location: Use of CRISPR-Cas9 for genome editing in human pathogenic fungi. PLoS Pathog (2017) 0.75
Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression. PLoS Pathog (2017) 0.75