Published in Mol Microbiol on May 01, 2007
Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans. Cell (2008) 2.71
Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been. Genes Dev (2009) 2.37
Sub-telomere directed gene expression during initiation of invasive aspergillosis. PLoS Pathog (2008) 2.09
A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus. PLoS Pathog (2008) 2.09
Regulatory circuitry governing fungal development, drug resistance, and disease. Microbiol Mol Biol Rev (2011) 1.90
Iron source preference and regulation of iron uptake in Cryptococcus neoformans. PLoS Pathog (2008) 1.65
In vivo hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis. PLoS Pathog (2011) 1.60
Sterol regulatory element binding proteins in fungi: hypoxic transcription factors linked to pathogenesis. Eukaryot Cell (2010) 1.49
Iron - A Key Nexus in the Virulence of Aspergillus fumigatus. Front Microbiol (2012) 1.48
HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans. PLoS Pathog (2010) 1.47
SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus. PLoS Genet (2011) 1.46
The Cryptococcus neoformans capsule: a sword and a shield. Clin Microbiol Rev (2012) 1.45
Antifungal resistance and new strategies to control fungal infections. Int J Microbiol (2011) 1.44
Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms. Nat Rev Microbiol (2009) 1.39
Role of NMDA receptor-dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries. Nat Med (2009) 1.36
Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia. J Proteome Res (2011) 1.22
4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress. J Biol Chem (2007) 1.22
Hypoxia and fungal pathogenesis: to air or not to air? Eukaryot Cell (2012) 1.18
Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis. Cold Spring Harb Perspect Med (2014) 1.18
Metabolic remodeling in iron-deficient fungi. Biochim Biophys Acta (2012) 1.17
Fungal adaptation to the mammalian host: it is a new world, after all. Curr Opin Microbiol (2008) 1.15
Adaptation of Cryptococcus neoformans to mammalian hosts: integrated regulation of metabolism and virulence. Eukaryot Cell (2011) 1.14
Regulation of the hypoxic response in Candida albicans. Eukaryot Cell (2010) 1.11
Cryptococcus neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs. Mol Microbiol (2009) 1.11
Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter. BMC Genomics (2012) 1.11
Aspergillus fumigatus metabolism: clues to mechanisms of in vivo fungal growth and virulence. Med Mycol (2009) 1.06
SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A). Antimicrob Agents Chemother (2011) 1.05
Importance of mitochondria in survival of Cryptococcus neoformans under low oxygen conditions and tolerance to cobalt chloride. PLoS Pathog (2008) 1.04
Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi? Med Mycol (2010) 1.04
Core principles of intramembrane proteolysis: comparison of rhomboid and site-2 family proteases. Curr Opin Struct Biol (2008) 1.04
Dsc orthologs are required for hypoxia adaptation, triazole drug responses, and fungal virulence in Aspergillus fumigatus. Eukaryot Cell (2012) 1.01
Biosynthesis and immunogenicity of glucosylceramide in Cryptococcus neoformans and other human pathogens. Eukaryot Cell (2007) 1.00
ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence. PLoS Pathog (2014) 1.00
Conservation of the sterol regulatory element-binding protein pathway and its pathobiological importance in Cryptococcus neoformans. Eukaryot Cell (2009) 0.98
Enhancement of carotenoid production by disrupting the C22-sterol desaturase gene (CYP61) in Xanthophyllomyces dendrorhous. BMC Microbiol (2012) 0.97
Synergistic regulation of hyphal elongation by hypoxia, CO(2), and nutrient conditions controls the virulence of Candida albicans. Cell Host Microbe (2013) 0.97
Molecular mechanisms of cryptococcal meningitis. Virulence (2012) 0.97
Systematic functional profiling of transcription factor networks in Cryptococcus neoformans. Nat Commun (2015) 0.96
Ergosterol regulates sterol regulatory element binding protein (SREBP) cleavage in fission yeast. J Biol Chem (2010) 0.96
Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach. BMC Syst Biol (2012) 0.96
Cytoplasmic localization of sterol transcription factors Upc2p and Ecm22p in S. cerevisiae. Fungal Genet Biol (2008) 0.96
New insights into S2P signaling cascades: regulation, variation, and conservation. Protein Sci (2010) 0.95
Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype A. BMC Microbiol (2011) 0.91
A multi-host approach for the systematic analysis of virulence factors in Cryptococcus neoformans. J Infect Dis (2014) 0.88
Composite survival index to compare virulence changes in azole-resistant Aspergillus fumigatus clinical isolates. PLoS One (2013) 0.87
Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in Cryptococcus neoformans. Mol Microbiol (2012) 0.87
Fungal killing by mammalian phagocytic cells. Curr Opin Microbiol (2008) 0.87
Two C4-sterol methyl oxidases (Erg25) catalyse ergosterol intermediate demethylation and impact environmental stress adaptation in Aspergillus fumigatus. Microbiology (2014) 0.84
Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation. Mol Biol Cell (2012) 0.82
A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. Eukaryot Cell (2011) 0.82
Coordination of hypoxia adaptation and iron homeostasis in human pathogenic fungi. Front Microbiol (2012) 0.81
RbdB, a Rhomboid Protease Critical for SREBP Activation and Virulence in Aspergillus fumigatus. mSphere (2016) 0.80
Overexpression of TUF1 restores respiratory growth and fluconazole sensitivity to a Cryptococcus neoformans vad1Delta mutant. Microbiology (2010) 0.80
Heme biosynthesis and its regulation: towards understanding and improvement of heme biosynthesis in filamentous fungi. Appl Microbiol Biotechnol (2011) 0.80
Transcriptional response to hypoxia in the aquatic fungus Blastocladiella emersonii. Eukaryot Cell (2010) 0.79
Role of actin-bundling protein Sac6 in growth of Cryptococcus neoformans at low oxygen concentration. Eukaryot Cell (2012) 0.78
Aimless mutants of Cryptococcus neoformans: failure to disseminate. Fungal Biol Rev (2012) 0.78
Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. J Biol Chem (2013) 0.78
A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP. EMBO J (2016) 0.77
Function and Regulation of Cph2 in Candida albicans. Eukaryot Cell (2015) 0.77
Characterization of the Paracoccidioides Hypoxia Response Reveals New Insights into Pathogenesis Mechanisms of This Important Human Pathogenic Fungus. PLoS Negl Trop Dis (2015) 0.77
The Zinc Finger Protein Mig1 Regulates Mitochondrial Function and Azole Drug Susceptibility in the Pathogenic Fungus Cryptococcus neoformans. mSphere (2016) 0.77
Heterogeneity among Isolates Reveals that Fitness in Low Oxygen Correlates with Aspergillus fumigatus Virulence. MBio (2016) 0.77
Functional profiling of human fungal pathogen genomes. Cold Spring Harb Perspect Med (2014) 0.77
A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions. PLoS Pathog (2017) 0.77
Genomic and transcriptomic analyses of the tangerine pathotype of Alternaria alternata in response to oxidative stress. Sci Rep (2016) 0.76
Molecular mechanisms of hypoxic responses via unique roles of Ras1, Cdc24 and Ptp3 in a human fungal pathogen Cryptococcus neoformans. PLoS Genet (2014) 0.76
Genome-Wide Analysis of Hypoxia-Responsive Genes in the Rice Blast Fungus, Magnaporthe oryzae. PLoS One (2015) 0.76
Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison. Front Cell Infect Microbiol (2016) 0.75
Unraveling Fungal Radiation Resistance Regulatory Networks through the Genome-Wide Transcriptome and Genetic Analyses of Cryptococcus neoformans. MBio (2016) 0.75
A P4 - ATPase subunit of the Cdc50 family plays a role in iron acquisition and virulence in Cryptococcus neoformans. Cell Microbiol (2017) 0.75
Deciphering the Regulatory Network between the SREBP Pathway and Protein Secretion in Neurospora crassa. MBio (2017) 0.75
Sensitisation of an Azole-Resistant Aspergillus fumigatus Strain containing the Cyp51A-Related Mutation by Deleting the SrbA Gene. Sci Rep (2016) 0.75
Regulation of Sterol Biosynthesis in the Human Fungal Pathogen Aspergillus fumigatus: Opportunities for Therapeutic Development. Front Microbiol (2017) 0.75
Identification of genes expressed by Cryptococcus gattii during iron deprivation. Braz J Microbiol (2014) 0.75
Sterol Regulatory Element Binding Protein (Srb1) Is Required for Hypoxic Adaptation and Virulence in the Dimorphic Fungus Histoplasma capsulatum. PLoS One (2016) 0.75
Disarming Fungal Pathogens: Bacillus safensis Inhibits Virulence Factor Production and Biofilm Formation by Cryptococcus neoformans and Candida albicans. MBio (2017) 0.75
NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res (2012) 15.84
Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell (2002) 5.70
SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast. Cell (2005) 2.81
Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been. Genes Dev (2009) 2.37
LEAFY COTYLEDON1-LIKE defines a class of regulators essential for embryo development. Plant Cell (2003) 2.36
Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes. Cell Metab (2007) 2.30
Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast. Mol Cell Biol (2006) 2.11
Human polymorphonuclear leukocytes inhibit Aspergillus fumigatus conidial growth by lactoferrin-mediated iron depletion. J Immunol (2007) 2.05
Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes. PLoS Pathog (2010) 2.04
Cryptococcal yeast cells invade the central nervous system via transcellular penetration of the blood-brain barrier. Infect Immun (2004) 1.99
Hierarchical modularity and the evolution of genetic interactomes across species. Mol Cell (2012) 1.88
MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer. Genes Dev (2011) 1.85
Expanding roles for SREBP in metabolism. Cell Metab (2012) 1.76
Cryptococcus neoformans strains and infection in apparently immunocompetent patients, China. Emerg Infect Dis (2008) 1.72
Invasive aspergillosis due to Neosartorya udagawae. Clin Infect Dis (2009) 1.70
Gliotoxin is a virulence factor of Aspergillus fumigatus: gliP deletion attenuates virulence in mice immunosuppressed with hydrocortisone. Eukaryot Cell (2007) 1.69
Complementation of a capsule deficient Cryptococcus neoformans with CAP64 restores virulence in a murine lung infection. Am J Respir Cell Mol Biol (2002) 1.65
Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member. EMBO J (2008) 1.61
Sterol regulatory element binding proteins in fungi: hypoxic transcription factors linked to pathogenesis. Eukaryot Cell (2010) 1.49
Role of laeA in the Regulation of alb1, gliP, Conidial Morphology, and Virulence in Aspergillus fumigatus. Eukaryot Cell (2007) 1.41
Genes differentially expressed in conidia and hyphae of Aspergillus fumigatus upon exposure to human neutrophils. PLoS One (2008) 1.34
Prevalence of the VNIc genotype of Cryptococcus neoformans in non-HIV-associated cryptococcosis in the Republic of Korea. FEMS Yeast Res (2010) 1.32
Heteroresistance to fluconazole in Cryptococcus neoformans is intrinsic and associated with virulence. Antimicrob Agents Chemother (2009) 1.31
Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells. Cell Microbiol (2008) 1.27
The primary target organ of Cryptococcus gattii is different from that of Cryptococcus neoformans in a murine model. MBio (2012) 1.22
4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress. J Biol Chem (2007) 1.22
Regulation of HMG-CoA reductase in mammals and yeast. Prog Lipid Res (2011) 1.22
Aspergillus fumigatus conidial melanin modulates host cytokine response. Immunobiology (2009) 1.21
SREBP controls oxygen-dependent mobilization of retrotransposons in fission yeast. PLoS Genet (2007) 1.21
Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast. EMBO J (2009) 1.20
Cas3p belongs to a seven-member family of capsule structure designer proteins. Eukaryot Cell (2004) 1.19
Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans. Mol Microbiol (2007) 1.17
Identification of a Cryptococcus neoformans cytochrome P450 lanosterol 14α-demethylase (Erg11) residue critical for differential susceptibility between fluconazole/voriconazole and itraconazole/posaconazole. Antimicrob Agents Chemother (2011) 1.16
Cloning and functional characterization of the Rhizopus oryzae high affinity iron permease (rFTR1) gene. FEMS Microbiol Lett (2004) 1.11
Cryptococcus neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs. Mol Microbiol (2009) 1.11
Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection. Eukaryot Cell (2007) 1.11
Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Mol Cell (2011) 1.11
Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast. Cell Metab (2008) 1.09
Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. J Biol Chem (2011) 1.07
Degradation of sterol regulatory element-binding protein precursor requires the endoplasmic reticulum-associated degradation components Ubc7 and Hrd1 in fission yeast. J Biol Chem (2009) 1.07
Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C-alpha activation. Cell Microbiol (2008) 1.05
Identification and characterization of an Aspergillus fumigatus "supermater" pair. MBio (2011) 1.04
Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3). J Biol Chem (2011) 1.04
Molecular analysis of CPRalpha, a MATalpha-specific pheromone receptor gene of Cryptococcus neoformans. Eukaryot Cell (2002) 1.04
Importance of mitochondria in survival of Cryptococcus neoformans under low oxygen conditions and tolerance to cobalt chloride. PLoS Pathog (2008) 1.04
Regulatory diversity of TUP1 in Cryptococcus neoformans. Eukaryot Cell (2009) 1.03
Aspergillus tanneri sp. nov., a new pathogen that causes invasive disease refractory to antifungal therapy. J Clin Microbiol (2012) 0.99
Hyaluronic acid receptor CD44 deficiency is associated with decreased Cryptococcus neoformans brain infection. J Biol Chem (2012) 0.99
Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding. Mol Cell (2011) 0.98
Conservation of the sterol regulatory element-binding protein pathway and its pathobiological importance in Cryptococcus neoformans. Eukaryot Cell (2009) 0.98
Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP). J Biol Chem (2014) 0.97
Cryptotrichosporon anacardii gen. nov., sp. nov., a new trichosporonoid capsulate basidiomycetous yeast from Nigeria that is able to form melanin on niger seed agar. FEMS Yeast Res (2006) 0.97
TUP1 disruption in Cryptococcus neoformans uncovers a peptide-mediated density-dependent growth phenomenon that mimics quorum sensing. Mol Microbiol (2007) 0.96
Ergosterol regulates sterol regulatory element binding protein (SREBP) cleavage in fission yeast. J Biol Chem (2010) 0.96
Bacterial endosymbiosis is widely present among zygomycetes but does not contribute to the pathogenesis of mucormycosis. J Infect Dis (2008) 0.95
Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP. J Lipid Res (2008) 0.95
Azole heteroresistance in Cryptococcus neoformans: emergence of resistant clones with chromosomal disomy in the mouse brain during fluconazole treatment. Antimicrob Agents Chemother (2013) 0.95
In defense against pathogens. Both plant sentinels and foot soldiers need to know the enemy. Plant Physiol (2003) 0.92
Novel polymorphic form of adefovir dipivoxil derived from polymer-directed crystallization. Pharmazie (2011) 0.90
Oxygen-dependent, alternative promoter controls translation of tco1+ in fission yeast. Nucleic Acids Res (2008) 0.90
Cryptococcus neoformans phospholipase B1 activates host cell Rac1 for traversal across the blood-brain barrier. Cell Microbiol (2012) 0.90
Overexpression of a cell wall glycoprotein in Fusarium oxysporum increases virulence and resistance to a plant PR-5 protein. Plant J (2003) 0.90
Identification of a novel gene, URE2, that functionally complements a urease-negative clinical strain of Cryptococcus neoformans. Microbiology (2006) 0.90
Invasive infection with Trichosporon inkin in 2 siblings with chronic granulomatous disease. J Allergy Clin Immunol (2004) 0.89
Factors required for activation of urease as a virulence determinant in Cryptococcus neoformans. MBio (2013) 0.88
Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in Cryptococcus neoformans. Mol Microbiol (2012) 0.87
Cryptococcus neoformans-derived microvesicles enhance the pathogenesis of fungal brain infection. PLoS One (2012) 0.87
Characterization of the chromosome 4 genes that affect fluconazole-induced disomy formation in Cryptococcus neoformans. PLoS One (2012) 0.87
Differences in nitrogen metabolism between Cryptococcus neoformans and C. gattii, the two etiologic agents of cryptococcosis. PLoS One (2012) 0.87
Cryptococcus neoformans with a mutation in the tetratricopeptide repeat-containing gene, CCN1, causes subcutaneous lesions but fails to cause systemic infection. Infect Immun (2003) 0.86
Olfm4 deletion enhances defense against Staphylococcus aureus in chronic granulomatous disease. J Clin Invest (2013) 0.86
Human leukocytes kill Aspergillus nidulans by reactive oxygen species-independent mechanisms. Infect Immun (2010) 0.86
Subunit architecture of the Golgi Dsc E3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. J Biol Chem (2013) 0.86
Cryptococcus neoformans activates RhoGTPase proteins followed by protein kinase C, focal adhesion kinase, and ezrin to promote traversal across the blood-brain barrier. J Biol Chem (2012) 0.84
Chloroquine modulates the fungal immune response in phagocytic cells from patients with chronic granulomatous disease. J Infect Dis (2013) 0.84
The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor. Structure (2011) 0.83
Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation. Mol Biol Cell (2012) 0.82
Rapid identification of antifungal compounds against Exserohilum rostratum using high throughput drug repurposing screens. PLoS One (2013) 0.80
Hematogenously disseminated skin disease caused by Mucor velutinosus in a patient with acute myeloid leukemia. J Clin Microbiol (2011) 0.80
Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis. J Biol Chem (2013) 0.79
Cryptococcus neoformans Yop1 , an endoplasmic reticulum curvature-stabilizing protein, participates with Sey1 in influencing fluconazole-induced disomy formation. FEMS Yeast Res (2012) 0.78
Role of actin-bundling protein Sac6 in growth of Cryptococcus neoformans at low oxygen concentration. Eukaryot Cell (2012) 0.78
Regulation of lipid metabolism: a tale of two yeasts. Curr Opin Cell Biol (2012) 0.78
Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. J Biol Chem (2013) 0.78
Glucose controls phosphoregulation of hydroxymethylglutaryl coenzyme A reductase through the protein phosphatase 2A-related phosphatase protein, Ppe1, and Insig in fission yeast. J Biol Chem (2011) 0.78
Identifying a static nonlinear structure in a biological system using noisy, sparse data. J Theor Biol (2012) 0.77
Polymer-directed crystallization of atorvastatin. J Pharm Sci (2012) 0.75