Published in Br J Pharmacol on January 13, 2015
Does Improving Vagal Tone Increase Mitochondrial Bioenergetics | NCT03931330
Acetylcholine ameliorates endoplasmic reticulum stress in endothelial cells after hypoxia/reoxygenation via M3 AChR-AMPK signaling. Cell Cycle (2015) 0.79
The role of heart rate variability in sports physiology. Exp Ther Med (2016) 0.76
Vagal nerve stimulation improves mitochondrial dynamics via an M3 receptor/CaMKKβ/AMPK pathway in isoproterenol-induced myocardial ischaemia. J Cell Mol Med (2016) 0.75
Muscarinic Stimulation Facilitates Sarcoplasmic Reticulum Ca Release by Modulating Ryanodine Receptor 2 Phosphorylation Through Protein Kinase G and Ca/Calmodulin-Dependent Protein Kinase II. Hypertension (2016) 0.75
Inhibition of the mitochondrial unfolded protein response by acetylcholine alleviated hypoxia/reoxygenation-induced apoptosis of endothelial cells. Cell Cycle (2016) 0.75
Cocaine cardiovascular effects and pharmacokinetics after treatment with the acetylcholinesterase inhibitor donepezil. Am J Addict (2016) 0.75
Chinese innovation in cardiovascular drug discovery. Br J Pharmacol (2015) 0.75
Long-term administration of pyridostigmine attenuates pressure overload-induced cardiac hypertrophy by inhibiting calcineurin signalling. J Cell Mol Med (2017) 0.75
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature (2000) 11.49
The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucleic Acids Res (2013) 9.61
The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol (2013) 5.74
The Concise Guide to PHARMACOLOGY 2013/14: enzymes. Br J Pharmacol (2013) 5.57
Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest (2007) 5.55
A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nat Med (2008) 3.98
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications. J Am Coll Cardiol (2009) 3.55
Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans. Br J Pharmacol (2008) 3.39
Chronic vagus nerve stimulation: a new and promising therapeutic approach for chronic heart failure. Eur Heart J (2010) 2.86
The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation. Br J Pharmacol (2007) 2.82
Rosuvastatin decreases caveolin-1 and improves nitric oxide-dependent heart rate and blood pressure variability in apolipoprotein E-/- mice in vivo. Circulation (2003) 2.35
The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway and implications for therapy. J Intern Med (2011) 2.08
Exercise protects the cardiovascular system: effects beyond traditional risk factors. J Physiol (2009) 2.01
Sympathetic nervous system activation in human heart failure: clinical implications of an updated model. J Am Coll Cardiol (2009) 1.88
The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels. Br J Pharmacol (2013) 1.88
Exercise-induced increase in baroreflex sensitivity predicts improved prognosis after myocardial infarction. Circulation (2002) 1.84
Calcium cycling proteins and heart failure: mechanisms and therapeutics. J Clin Invest (2013) 1.74
Slow breathing improves arterial baroreflex sensitivity and decreases blood pressure in essential hypertension. Hypertension (2005) 1.67
Atorvastatin therapy increases heart rate variability, decreases QT variability, and shortens QTc interval duration in patients with advanced chronic heart failure. J Card Fail (2005) 1.66
Long term vagal stimulation in patients with advanced heart failure: first experience in man. Eur J Heart Fail (2008) 1.63
Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction. Cardiovasc Res (2007) 1.62
Phosphoinositide 3-kinase signalling in the vascular system. Cardiovasc Res (2008) 1.51
Tumour necrosis factor-α and its receptors in the beneficial effects of vagal stimulation after myocardial infarction in rats. Clin Exp Pharmacol Physiol (2011) 1.45
Autonomic neural regulation of the immune system: implications for hypertension and cardiovascular disease. Hypertension (2012) 1.45
Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure. Eur J Heart Fail (2014) 1.42
Mitochondria as a drug target in ischemic heart disease and cardiomyopathy. Circ Res (2012) 1.31
Slow breathing increases arterial baroreflex sensitivity in patients with chronic heart failure. Circulation (2002) 1.27
Mitochondria and endothelial function. Circ Res (2013) 1.27
Muscarinic acetylcholine receptors: novel opportunities for drug development. Nat Rev Drug Discov (2014) 1.21
Vagal stimulation, through its nicotinic action, limits infarct size and the inflammatory response to myocardial ischemia and reperfusion. J Cardiovasc Pharmacol (2011) 1.21
Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect. J Thorac Cardiovasc Surg (2009) 1.20
Statin therapy restores sympathovagal balance in experimental heart failure. J Appl Physiol (1985) (2003) 1.19
Prognostic implications of baroreflex sensitivity in heart failure patients in the beta-blocking era. J Am Coll Cardiol (2009) 1.18
Mitochondria in vascular health and disease. Annu Rev Physiol (2012) 1.08
Choline produces cytoprotective effects against ischemic myocardial injuries: evidence for the role of cardiac m3 subtype muscarinic acetylcholine receptors. Cell Physiol Biochem (2005) 1.08
Cytokines and the immunomodulatory function of the vagus nerve. Br J Anaesth (2009) 1.07
Depressing mitochondria-reticulum interactions protects cardiomyocytes from lethal hypoxia-reoxygenation injury. Circulation (2013) 1.04
Prediction of heart rate variability on cardiac sudden death in heart failure patients: a systematic review. Int J Cardiol (2014) 1.02
Mitochondria, endothelial cell function, and vascular diseases. Front Physiol (2014) 1.02
Non-neuronal nicotinic alpha 7 receptor, a new endothelial target for revascularization. Life Sci (2005) 1.01
Molecular mechanisms of neuronal nitric oxide synthase in cardiac function and pathophysiology. J Physiol (2014) 0.99
Vagus nerve stimulation improves left ventricular function in a canine model of chronic heart failure. Eur J Heart Fail (2013) 0.99
Autonomic regulation therapy for the improvement of left ventricular function and heart failure symptoms: the ANTHEM-HF study. J Card Fail (2013) 0.99
α7 nicotinic acetylcholine receptor signaling inhibits inflammasome activation by preventing mitochondrial DNA release. Mol Med (2014) 0.97
Muscarinic receptor knockout mice confirm involvement of M3 receptor in endothelium-dependent vasodilatation in mouse arteries. J Cardiovasc Pharmacol (2008) 0.97
Muscarinic (M) receptors in coronary circulation: gene-targeted mice define the role of M2 and M3 receptors in response to acetylcholine. Arterioscler Thromb Vasc Biol (2004) 0.97
Endothelial nicotinic acetylcholine receptors and angiogenesis. Trends Cardiovasc Med (2008) 0.96
Acetylcholine prevents angiotensin II-induced oxidative stress and apoptosis in H9c2 cells. Apoptosis (2011) 0.95
Phorbol esters and adenosine affect the readily releasable neurotransmitter pool by different mechanisms at amphibian motor nerve endings. J Physiol (2003) 0.94
Endothelial mitochondria--less respiration, more integration. Pflugers Arch (2012) 0.94
Increase in parasympathetic tone by pyridostigmine prevents ventricular dysfunction during the onset of heart failure. Am J Physiol Regul Integr Comp Physiol (2013) 0.94
Nitric oxide, a protective molecule in the cardiovascular system. Nitric Oxide (2013) 0.94
The Walter B. Cannon Memorial Award Lecture, 2009. Physiology in perspective: The wisdom of the body. In search of autonomic balance: the good, the bad, and the ugly. Am J Physiol Regul Integr Comp Physiol (2010) 0.94
Activation of cardiac muscarinic M3 receptors induces delayed cardioprotection by preserving phosphorylated connexin43 and up-regulating cyclooxygenase-2 expression. Br J Pharmacol (2010) 0.93
Vagal stimulation for heart diseases: from animals to men. - An example of translational cardiology.-. Circ J (2010) 0.93
Muscarinic receptor agonists and antagonists: effects on cardiovascular function. Handb Exp Pharmacol (2012) 0.93
Lipid lowering by pravastatin increases parasympathetic modulation of heart rate: Galpha(i2), a possible molecular marker for parasympathetic responsiveness. Circulation (2003) 0.93
Clinical value of baroreflex sensitivity. Neth Heart J (2013) 0.91
Cardioprotection by acetylcholine: a novel mechanism via mitochondrial biogenesis and function involving the PGC-1α pathway. J Cell Physiol (2013) 0.91
Targeting calcium transport in ischaemic heart disease. Cardiovasc Res (2009) 0.91
Protection against ischemia-induced oxidative stress conferred by vagal stimulation in the rat heart: involvement of the AMPK-PKC pathway. Int J Mol Sci (2012) 0.91
Changes in heart rate variability are correlated to hemodynamic improvement with chronic CARVEDILOL therapy in heart failure. J Card Fail (2005) 0.90
Vagal stimulation triggers peripheral vascular protection through the cholinergic anti-inflammatory pathway in a rat model of myocardial ischemia/reperfusion. Basic Res Cardiol (2013) 0.90
Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on phosphatidylinositol 3- and Src-kinase activation and mitochondrial K(ATP) channel opening. J Mol Cell Cardiol (2003) 0.89
Pyridostigmine restores cardiac autonomic balance after small myocardial infarction in mice. PLoS One (2014) 0.89
Nonselective beta-adrenergic blocking agent, carvedilol, improves arterial baroflex gain and heart rate variability in patients with stable chronic heart failure. J Am Coll Cardiol (2000) 0.87
Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice. Am J Physiol Heart Circ Physiol (2011) 0.87
Acetylcholine mediates AMPK-dependent autophagic cytoprotection in H9c2 cells during hypoxia/reoxygenation injury. Cell Physiol Biochem (2013) 0.87
Cardiovascular dysfunctions and sympathovagal imbalance in hypertension and prehypertension: physiological perspectives. Future Cardiol (2013) 0.86
Exercise training improves cardiovascular autonomic activity and attenuates renal damage in spontaneously hypertensive rats. J Sports Sci Med (2013) 0.86
Vagal nerve stimulation protects cardiac injury by attenuating mitochondrial dysfunction in a murine burn injury model. J Cell Mol Med (2013) 0.86
Early short-term vagal nerve stimulation attenuates cardiac remodeling after reperfused myocardial infarction. J Card Fail (2010) 0.85
High-intensity interval exercise improves vagal tone and decreases arrhythmias in chronic heart failure. Med Sci Sports Exerc (2013) 0.85
Optimizing the parameters of vagus nerve stimulation by uniform design in rats with acute myocardial infarction. PLoS One (2012) 0.84
Cardiovascular and respiratory effect of yogic slow breathing in the yoga beginner: what is the best approach? Evid Based Complement Alternat Med (2013) 0.84
Postconditioning with α7nAChR agonist attenuates systemic inflammatory response to myocardial ischemia--reperfusion injury in rats. Inflammation (2012) 0.83
Acetylcholine attenuates hypoxia/ reoxygenation-induced mitochondrial and cytosolic ROS formation in H9c2 cells via M2 acetylcholine receptor. Cell Physiol Biochem (2013) 0.83
Adenosine infusion inhibits adenosine-induced cardiac actions but enhances acetylcholine-induced actions in isolated dog atria. Heart Vessels (2003) 0.82
Overexpression of M₃ muscarinic receptor is a novel strategy for preventing sudden cardiac death in transgenic mice. Mol Med (2011) 0.82
Delayed preconditioning prevents ischemia/reperfusion-induced endothelial injury in rats: role of ROS and eNOS. Lab Invest (2012) 0.82
Long-term atorvastatin improves age-related endothelial dysfunction by ameliorating oxidative stress and normalizing eNOS/iNOS imbalance in rat aorta. Exp Gerontol (2014) 0.82
A potential role of alpha-7 nicotinic acetylcholine receptor in cardiac angiogenesis in a pressure-overload rat model. J Pharmacol Sci (2010) 0.82
Choline inhibits angiotensin II-induced cardiac hypertrophy by intracellular calcium signal and p38 MAPK pathway. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.82
Acetylcholine inhibits hypoxia-induced tumor necrosis factor-α production via regulation of MAPKs phosphorylation in cardiomyocytes. J Cell Physiol (2011) 0.82
Detection of endogenous acetylcholine release during brief ischemia in the rabbit ventricle: a possible trigger for ischemic preconditioning. Life Sci (2009) 0.82
Cholinergic signaling exerts protective effects in models of sympathetic hyperactivity-induced cardiac dysfunction. PLoS One (2014) 0.81
Thoracic vagal efferent nerve stimulation evokes substance P-induced early airway bronchonstriction and late proinflammatory and oxidative injury in the rat respiratory tract. J Biomed Sci (2005) 0.81
Acetylcholine inhibits tumor necrosis factor α activated endoplasmic reticulum apoptotic pathway via EGFR-PI3K signaling in cardiomyocytes. J Cell Physiol (2015) 0.81
Arginine and nitric oxide synthase: regulatory mechanisms and cardiovascular aspects. Mol Nutr Food Res (2013) 0.81
Activation of vagus nerve by semapimod alters substance P levels and decreases breast cancer metastasis. Regul Pept (2012) 0.81
Adenine sulfate improves cardiac function and the cardiac cholinergic system after myocardial infarction in rats. J Pharmacol Sci (2011) 0.80
Impact of vagal nerve stimulation on left atrial structure and function in a canine high-rate pacing model. Circ Heart Fail (2014) 0.80
Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases. Front Med (2012) 0.80
Activation of cardiac M3 muscarinic acetylcholine receptors has cardioprotective effects against ischaemia-induced arrhythmias. Clin Exp Pharmacol Physiol (2012) 0.80
Pyridostigmine ameliorates cardiac remodeling induced by myocardial infarction via inhibition of the transforming growth factor-β1/TGF-β1-activated kinase pathway. J Cardiovasc Pharmacol (2014) 0.80
[Vagal stimulation - a new possibility for conservative treatment of peripheral arterial occlusion disease]. Zentralbl Chir (2011) 0.79
Role of endothelial nitric oxide synthase and vagal activity in the endothelial protection of atorvastatin in ischemia/reperfusion injury. J Cardiovasc Pharmacol (2013) 0.79
Effects of exercise training on heart rate variability after coronary angioplasty. Phys Ther (2006) 0.79
Effects of postconditioning of adenosine and acetylcholine on the ischemic isolated rat ventricular myocytes. Eur J Pharmacol (2006) 0.78
Activation of M3 cholinoceptors attenuates vascular injury after ischaemia/reperfusion by inhibiting the Ca(2+) /calmodulin-dependent protein kinase II pathway. Br J Pharmacol (2015) 0.81
Acetylated FoxO1 mediates high-glucose induced autophagy in H9c2 cardiomyoblasts: regulation by a polyphenol -(-)-epigallocatechin-3-gallate. Metabolism (2014) 0.76