NK cell activation in human hantavirus infection explained by virus-induced IL-15/IL15Rα expression.

PubWeight™: 0.87‹?›

🔗 View Article (PMC 4239055)

Published in PLoS Pathog on November 20, 2014

Authors

Monika Braun1, Niklas K Björkström2, Shawon Gupta3, Karin Sundström3, Clas Ahlm4, Jonas Klingström5, Hans-Gustaf Ljunggren1

Author Affiliations

1: Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
2: Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; Liver Immunology Laboratory, Unit for Gastroenterology and Hepatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
3: Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
4: Department of Clinical Microbiology, Infectious Diseases, Umeå University, Umeå, Sweden.
5: Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

Articles cited by this

NK cell recognition. Annu Rev Immunol (2005) 14.40

Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol (1999) 9.55

Up on the tightrope: natural killer cell activation and inhibition. Nat Immunol (2008) 7.88

Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature (2005) 7.40

Human NK cell education by inhibitory receptors for MHC class I. Immunity (2006) 6.73

IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity (2002) 6.10

Hantavirus pulmonary syndrome. Pathogenesis of an emerging infectious disease. Am J Pathol (1995) 5.30

Interleukin 15: biology and relevance to human disease. Blood (2001) 4.47

Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J Exp Med (2002) 4.32

Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis. Nat Med (1997) 4.03

Specific and nonspecific NK cell activation during virus infection. Nat Immunol (2001) 4.02

Self-tolerance of natural killer cells. Nat Rev Immunol (2006) 3.75

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J (1995) 3.59

Natural killer cells as an initial defense against pathogens. Curr Opin Immunol (2006) 3.55

Regulation of human NK-cell cytokine and chemokine production by target cell recognition. Blood (2009) 3.46

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo. J Exp Med (2008) 3.03

Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus. J Exp Med (2010) 2.89

IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels. Immunity (1996) 2.23

Line of attack: NK cell specificity and integration of signals. Curr Opin Immunol (2008) 2.15

Hantavirus-induced immunity in rodent reservoirs and humans. Immunol Rev (2008) 2.08

Human natural killer cell deficiencies. Curr Opin Allergy Clin Immunol (2006) 2.02

NK cell education: not an on-off switch but a tunable rheostat. Trends Immunol (2009) 2.00

Control of human viral infections by natural killer cells. Annu Rev Immunol (2013) 1.96

Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. J Biol Chem (1995) 1.90

Uncovering the mysteries of hantavirus infections. Nat Rev Microbiol (2013) 1.75

NK cytotoxicity against CD4+ T cells during HIV-1 infection: a gp41 peptide induces the expression of an NKp44 ligand. Proc Natl Acad Sci U S A (2005) 1.67

The paradox of NKp46+ natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon α treatment. Gut (2013) 1.60

The natural killer cell-mediated killing of autologous dendritic cells is confined to a cell subset expressing CD94/NKG2A, but lacking inhibitory killer Ig-like receptors. Eur J Immunol (2003) 1.55

Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivo. J Clin Invest (1998) 1.50

Hantavirus regulation of endothelial cell functions. Thromb Haemost (2009) 1.39

NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha. J Clin Invest (2007) 1.37

Activation of natural killer cells during acute infection with hepatitis C virus. Gastroenterology (2010) 1.37

Long-lived memory T lymphocyte responses after hantavirus infection. J Exp Med (2002) 1.34

Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence. Blood (2010) 1.32

Puumala hantavirus viremia diagnosed by real-time reverse transcriptase PCR using samples from patients with hemorrhagic fever and renal syndrome. J Clin Microbiol (2007) 1.29

NK cells, displaying early activation, cytotoxicity and adhesion molecules, are associated with mild dengue disease. Clin Exp Immunol (2006) 1.22

Treatment of hantavirus pulmonary syndrome. Antiviral Res (2007) 1.21

Interleukin-15 triggers the proliferation and cytotoxicity of granular lymphocytes in patients with lymphoproliferative disease of granular lymphocytes. Blood (1997) 1.14

Viral activation of interleukin-15 (IL-15): characterization of a virus-inducible element in the IL-15 promoter region. J Virol (2000) 1.12

Up-regulation of NK cell activating receptors following allogeneic hematopoietic stem cell transplantation under a lymphodepleting reduced intensity regimen is associated with elevated IL-15 levels. Biol Blood Marrow Transplant (2008) 1.11

Loss of cell membrane integrity in puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin. J Virol (2006) 1.09

Longitudinal analysis of the human T cell response during acute hantavirus infection. J Virol (2011) 1.09

Natural killer cell activation by dendritic cells: balancing inhibitory and activating signals. Cell Mol Life Sci (2011) 1.07

Critical role of natural killer cells in lung immunopathology during influenza infection in mice. J Infect Dis (2012) 1.04

Differential responses to interleukin 2 define functionally distinct subsets of human natural killer cells. Eur J Immunol (1992) 1.02

Alpha/beta interferon (IFN-alpha/beta)-independent induction of IFN-lambda1 (interleukin-29) in response to Hantaan virus infection. J Virol (2010) 1.01

Dendritic cell editing by activated natural killer cells results in a more protective cancer-specific immune response. PLoS One (2012) 0.99

Changes in cytokine levels and NK cell activation associated with influenza. PLoS One (2011) 0.96

HFRS causing hantaviruses do not induce apoptosis in confluent Vero E6 and A-549 cells. J Med Virol (2005) 0.94

T cells and pathogenesis of hantavirus cardiopulmonary syndrome and hemorrhagic fever with renal syndrome. Viruses (2011) 0.94

Phase 1 trial of IL-15 trans presentation blockade using humanized Mikβ1 mAb in patients with T-cell large granular lymphocytic leukemia. Blood (2012) 0.93

Presence of activated airway T lymphocytes in human puumala hantavirus disease. Chest (2011) 0.92

Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis. PLoS Pathog (2013) 0.91

Pathophysiology of hantavirus pulmonary syndrome in rhesus macaques. Proc Natl Acad Sci U S A (2014) 0.90

Plasma cell-free DNA levels are elevated in acute Puumala hantavirus infection. PLoS One (2012) 0.89

RSV infection modulates IL-15 production and MICA levels in respiratory epithelial cells. Eur Respir J (2011) 0.87

NK cells are strongly activated by Lassa and Mopeia virus-infected human macrophages in vitro but do not mediate virus suppression. Eur J Immunol (2012) 0.84

Increased levels of IL-15 mRNA in relapsing--remitting multiple sclerosis attacks. J Neuroimmunol (2002) 0.84

Hantavirus protein interactions regulate cellular functions and signaling responses. Expert Rev Anti Infect Ther (2011) 0.83

Hantavirus infections: clinical presentation in the emergency room. Eur J Emerg Med (2001) 0.83

Hantaviral mechanisms driving HLA class I antigen presentation require both RIG-I and TRIF. Eur J Immunol (2013) 0.81

Tissue-specific expression of IL-15RA alternative splicing transcripts and its regulation by DNA methylation. Eur Cytokine Netw (2010) 0.80

Articles by these authors

Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis. PLoS Pathog (2013) 0.91

A need for One Health approach - lessons learned from outbreaks of Rift Valley fever in Saudi Arabia and Sudan. Infect Ecol Epidemiol (2014) 0.86

Association of Rift Valley fever virus infection with miscarriage in Sudanese women: a cross-sectional study. Lancet Glob Health (2016) 0.83

Molecular Diagnosis of Hemorrhagic Fever with Renal Syndrome Caused by Puumala Virus. J Clin Microbiol (2016) 0.80

Specificity and dynamics of effector and memory CD8 T cell responses in human tick-borne encephalitis virus infection. PLoS Pathog (2015) 0.78

Global emergence of Alphaviruses that cause arthritis in humans. Infect Ecol Epidemiol (2015) 0.78

High-Throughput Screening Using a Whole-Cell Virus Replication Reporter Gene Assay to Identify Inhibitory Compounds against Rift Valley Fever Virus Infection. J Biomol Screen (2016) 0.77

Association of ecological factors with Rift Valley fever occurrence and mapping of risk zones in Kenya. Int J Infect Dis (2016) 0.77

Remotely Sensed Environmental Conditions and Malaria Mortality in Three Malaria Endemic Regions in Western Kenya. PLoS One (2016) 0.76

Differences in Granule Morphology yet Equally Impaired Exocytosis among Cytotoxic T Cells and NK Cells from Chediak-Higashi Syndrome Patients. Front Immunol (2017) 0.75

Distribution and abundance of key vectors of Rift Valley fever and other arboviruses in two ecologically distinct counties in Kenya. PLoS Negl Trop Dis (2017) 0.75

Mosquito-borne Inkoo virus in northern Sweden - isolation and whole genome sequencing. Virol J (2017) 0.75

Islet autoantibodies present in association with Ljungan virus infection in bank voles (Myodes glareolus) in northern Sweden. J Med Virol (2016) 0.75

Circulation and diagnostics of Puumala virus in Norway: nephropatia epidemica incidence and rodent population dynamics. APMIS (2017) 0.75

Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways. PLoS Pathog (2017) 0.75