Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.

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Published in Oncogene on November 24, 2014

Authors

H Choudhry1,2, A Albukhari1,3, M Morotti3, S Haider3, D Moralli2, J Smythies4, J Schödel5, C M Green2, C Camps2, F Buffa6, P Ratcliffe4, J Ragoussis2,7,8, A L Harris3, D R Mole4

Author Affiliations

1: Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
2: The Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, UK.
3: Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford, Oxford, UK.
4: The Henry Wellcome Building for Molecular Physiology, University of Oxford, Headington, Oxford, UK.
5: Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
6: Old Road Campus Research Building, University of Oxford, Headington, Oxford, UK.
7: McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada.
8: BSRC Alexander Fleming, Athens, Greece.

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