p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity.

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Published in Nat Med on July 04, 2016

Authors

Carmen Adriaens1,2, Laura Standaert1,2, Jasmine Barra1,2, Mathilde Latil3, Annelien Verfaillie4, Peter Kalev5,6, Bram Boeckx7,8, Paul W G Wijnhoven9, Enrico Radaelli10, William Vermi11,12, Eleonora Leucci1,2, Gaëlle Lapouge3, Benjamin Beck3, Joost van den Oord13, Shinichi Nakagawa14,15, Tetsuro Hirose16, Anna A Sablina5,6, Diether Lambrechts7,8, Stein Aerts4, Cédric Blanpain3,17, Jean-Christophe Marine1,2

Author Affiliations

1: Laboratory for Molecular Cancer Biology, Center for the Biology of Disease, VIB, KU Leuven, Leuven, Belgium.
2: Laboratory for Molecular Cancer Biology, Center for Human Genetics, KU Leuven, Leuven, Belgium.
3: Université Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, Bruxelles, Belgium.
4: Laboratory of Computational Biology, Center for Human Genetics, KU Leuven, Leuven, Belgium.
5: Laboratory for Mechanisms of Cell Transformation, Center for the Biology of Disease, VIB, KU Leuven, Leuven, Belgium.
6: Laboratory for Mechanisms of Cell Transformation, Center for Human Genetics, KU Leuven, Leuven, Belgium.
7: Vesalius Research Center, VIB, KU Leuven, Leuven, Belgium.
8: Laboratory for Translational Genetics, Department of Oncology, KU Leuven, Leuven, Belgium.
9: The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.
10: Mouse Histopathology Core Facility, Center for the Biology of Disease, VIB, KU Leuven, Leuven, Belgium.
11: Section of Pathology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
12: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
13: Laboratory of Translational Cell and Tissue Research, Department of Pathology, KU Leuven and UZ Leuven, Leuven, Belgium.
14: RNA Biology Laboratory, RIKEN, Wako, Japan.
15: Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
16: Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
17: WELBIO, Université Libre de Bruxelles, Bruxelles, Belgium.

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