Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α.

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Published in Genes Dev on December 01, 2014

Authors

Romain Baer1, Célia Cintas1, Marlène Dufresne2, Stéphanie Cassant-Sourdy1, Nina Schönhuber3, Laetitia Planque1, Hubert Lulka2, Bettina Couderc2, Corinne Bousquet1, Barbara Garmy-Susini4, Bart Vanhaesebroeck5, Stéphane Pyronnet1, Dieter Saur6, Julie Guillermet-Guibert1

Author Affiliations

1: UMR1037, Le Centre de Recherches en Cancérologie de Toulouse (CRCT), Inserm, F-31000 Toulouse, France; UMR1037, CRCT, Université Toulouse III-Paul Sabatier, F-31000 Toulouse, France; Equipe Labellisée Ligue Contre le Cancer, F-31000 Toulouse, France;
2: UMR1037, Le Centre de Recherches en Cancérologie de Toulouse (CRCT), Inserm, F-31000 Toulouse, France; UMR1037, CRCT, Université Toulouse III-Paul Sabatier, F-31000 Toulouse, France;
3: Department of Internal Medicine 2, Technische Universität München, 81675 Munich, Germany;
4: UMR1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Inserm, F-31000 Toulouse, France; Université Toulouse III-Paul Sabatier, F-31000 Toulouse, France;
5: Cell Signaling, UCL Cancer Institute, University College London, London WC1E 6DD, United Kingdom;
6: Department of Internal Medicine 2, Technische Universität München, 81675 Munich, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

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