Published in Cancer Cell on November 29, 2012
Monitoring and Managing Glucose Levels in People With Pancreatic Cancer (PEGASUS) | NCT05132244
Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia. Cancer Cell (2014) 3.29
Organoid models of human and mouse ductal pancreatic cancer. Cell (2014) 2.99
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J (2013) 2.24
Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proc Natl Acad Sci U S A (2014) 1.89
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. Nat Cell Biol (2014) 1.87
Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer. Mol Cancer (2015) 1.75
Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma. Proc Natl Acad Sci U S A (2013) 1.67
Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma. Sci Signal (2014) 1.61
Identification and manipulation of biliary metaplasia in pancreatic tumors. Gastroenterology (2013) 1.60
Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut (2013) 1.58
Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation. Genes Dev (2015) 1.58
KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis. Cancer Cell (2016) 1.49
The basic helix-loop-helix transcription factor E47 reprograms human pancreatic cancer cells to a quiescent acinar state with reduced tumorigenic potential. Pancreas (2015) 1.42
Neat1 is a p53-inducible lincRNA essential for transformation suppression. Genes Dev (2017) 1.39
The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis. Genes Dev (2013) 1.28
Control of cell identity in pancreas development and regeneration. Gastroenterology (2013) 1.24
Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance. Cancer Res (2013) 1.24
Plasticity and dedifferentiation within the pancreas: development, homeostasis, and disease. Cell Stem Cell (2014) 1.21
An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression. Cell Rep (2013) 1.21
Pancreatitis-diabetes-pancreatic cancer: summary of an NIDDK-NCI workshop. Pancreas (2013) 1.15
Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract. Sci Signal (2015) 1.15
Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia. Nat Commun (2015) 1.14
Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev (2016) 1.13
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas. Am J Surg Pathol (2015) 1.09
Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas. Proc Natl Acad Sci U S A (2014) 1.03
The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma. Elife (2015) 1.03
Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma. Oncotarget (2014) 1.03
Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing. Genes Dev (2015) 1.00
The versatile functions of Sox9 in development, stem cells, and human diseases. Genes Dis (2014) 0.98
β1 integrin is a crucial regulator of pancreatic β-cell expansion. Development (2013) 0.97
The use of stem cells for pancreatic regeneration in diabetes mellitus. Nat Rev Endocrinol (2013) 0.97
Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of Hhex in Mice. Cell Mol Gastroenterol Hepatol (2015) 0.97
Regulation of Cellular Identity in Cancer. Dev Cell (2015) 0.96
Notch signaling in pancreatic cancer: oncogene or tumor suppressor? Trends Mol Med (2013) 0.95
Loss of HNF6 expression correlates with human pancreatic cancer progression. Lab Invest (2014) 0.95
Regeneration and repair of the exocrine pancreas. Annu Rev Physiol (2014) 0.94
Pancreatic Cancer Metastases Harbor Evidence of Polyclonality. Cancer Discov (2015) 0.94
NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas. Gastroenterology (2015) 0.94
Stem cells versus plasticity in liver and pancreas regeneration. Nat Cell Biol (2016) 0.92
MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in mice. Gastroenterology (2013) 0.91
Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. Lab Invest (2014) 0.90
Pathology of pancreatic ductal adenocarcinoma: facts, challenges and future developments. World J Gastroenterol (2014) 0.90
SOX9: a useful marker for pancreatic ductal lineage of pancreatic neoplasms. Hum Pathol (2013) 0.88
Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis. Sci Rep (2015) 0.85
SOX9 drives WNT pathway activation in prostate cancer. J Clin Invest (2016) 0.85
Sox9: a master regulator of the pancreatic program. Rev Diabet Stud (2014) 0.84
SOX10, a novel HMG-box-containing tumor suppressor, inhibits growth and metastasis of digestive cancers by suppressing the Wnt/β-catenin pathway. Oncotarget (2014) 0.84
Disputed paternity: the uncertain ancestry of pancreatic ductal neoplasia. Cancer Cell (2012) 0.84
Pathogenesis of pancreatic cancer: lessons from animal models. Toxicol Pathol (2013) 0.84
Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α. Genes Dev (2014) 0.83
SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res (2016) 0.83
FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma. EMBO J (2016) 0.83
SOX9 inhibits β-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties. J Cell Sci (2015) 0.83
A concise review on the current understanding of pancreatic cancer stem cells. J Cancer Stem Cell Res (2015) 0.82
Dicer regulates differentiation and viability during mouse pancreatic cancer initiation. PLoS One (2014) 0.82
The role of Sox9 in mouse mammary gland development and maintenance of mammary stem and luminal progenitor cells. BMC Dev Biol (2014) 0.82
Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma. Cancer Res (2014) 0.81
Pancreatic Cancer Genetics. Int J Biol Sci (2016) 0.81
Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. Genes Dev (2016) 0.81
Sox9-dependent acinar-to-ductal reprogramming is critical for pancreatic intraepithelial neoplasia formation. Gastroenterology (2013) 0.81
A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics. Dis Model Mech (2015) 0.81
Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style. Nat Rev Mol Cell Biol (2016) 0.81
Deregulation of the MiR-193b-KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer. PLoS One (2015) 0.81
The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype. Cancer Res (2016) 0.80
Discrimination between adenocarcinoma and normal pancreatic ductal fluid by proteomic and glycomic analysis. J Proteome Res (2013) 0.80
p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells. Oncogene (2015) 0.80
SOX15 and other SOX family members are important mediators of tumorigenesis in multiple cancer types. Oncoscience (2014) 0.80
The secret origins and surprising fates of pancreas tumors. Carcinogenesis (2014) 0.80
Kras(G12D) induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells. Oncogene (2015) 0.79
The tumor suppressor rpl36 restrains KRAS(G12V)-induced pancreatic cancer. Zebrafish (2014) 0.79
Impact of Sox9 dosage and Hes1-mediated Notch signaling in controlling the plasticity of adult pancreatic duct cells in mice. Sci Rep (2015) 0.79
Pancreatic acinar cell carcinoma presenting with panniculitis, successfully treated with FOLFIRINOX: A case report. Mol Clin Oncol (2017) 0.79
Silencing of SOX12 by shRNA suppresses migration, invasion and proliferation of breast cancer cells. Biosci Rep (2016) 0.78
Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis. PLoS One (2015) 0.78
Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer. Oncogene (2015) 0.78
Animal Models of Gastrointestinal and Liver Diseases. The difficulty of animal modeling of pancreatic cancer for preclinical evaluation of therapeutics. Am J Physiol Gastrointest Liver Physiol (2015) 0.78
Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature (2017) 0.77
Valproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation Programs. Am J Pathol (2015) 0.77
Macrophages and pancreatic ductal adenocarcinoma. Cancer Lett (2015) 0.77
Loss of p27Kip1 promotes metaplasia in the pancreas via the regulation of Sox9 expression. Oncotarget (2015) 0.77
Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition. Nat Commun (2015) 0.77
Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia. PLoS One (2014) 0.77
Cells of origin of pancreatic neoplasms. Surg Today (2017) 0.77
Role of β-catenin in development of bile ducts. Differentiation (2016) 0.76
A Transient Metabolic Recovery from Early Life Glucose Intolerance in Cystic Fibrosis Ferrets Occurs During Pancreatic Remodeling. Endocrinology (2016) 0.76
TGF-β1 promotes acinar to ductal metaplasia of human pancreatic acinar cells. Sci Rep (2016) 0.76
NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation. Stem Cells Int (2015) 0.76
Regulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor Microenvironment. Clin Cancer Res (2016) 0.76
Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia. EMBO Mol Med (2013) 0.76
The impact of hypoxia in pancreatic cancer invasion and metastasis. Hypoxia (Auckl) (2014) 0.76
Pancreatic cancer from bench to bedside: molecular pathways and treatment options. Ann Transl Med (2016) 0.75
Reg proteins promote acinar-to-ductal metaplasia and act as novel diagnostic and prognostic markers in pancreatic ductal adenocarcinoma. Oncotarget (2016) 0.75
Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia. Sci Rep (2016) 0.75
Phosphatidylinositol 3-Kinase: A Link Between Inflammation and Pancreatic Cancer. Pancreas (2016) 0.75
Prox1-Heterozygosis Sensitizes the Pancreas to Oncogenic Kras-Induced Neoplastic Transformation. Neoplasia (2016) 0.75
ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation. Oncogene (2016) 0.75
Slug inhibits pancreatic cancer initiation by blocking Kras-induced acinar-ductal metaplasia. Sci Rep (2016) 0.75
Upregulation of microRNA-524-5p enhances the cisplatin sensitivity of gastric cancer cells by modulating proliferation and metastasis via targeting SOX9. Oncotarget (2016) 0.75
Anterior Gradient 2 (AGR2) Induced Epidermal Growth Factor Receptor (EGFR) Signaling Is Essential for Murine Pancreatitis-Associated Tissue Regeneration. PLoS One (2016) 0.75
Proteasome activity is required for the initiation of precancerous pancreatic lesions. Sci Rep (2016) 0.75
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell (2003) 15.43
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell (2005) 14.21
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell (2007) 8.47
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev (2003) 8.27
Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev (2006) 8.26
Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med (1993) 7.67
Cells of origin in cancer. Nature (2011) 6.85
Identification of a cell of origin for human prostate cancer. Science (2010) 6.33
Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell (2003) 5.36
Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group. J Natl Cancer Inst (1997) 4.23
SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A (2007) 4.19
Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth. Dev Cell (2009) 3.63
Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration. Gastroenterology (2005) 3.56
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A (2008) 3.43
In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia. Gastroenterology (2007) 3.41
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci U S A (2008) 3.40
Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell (2009) 3.37
Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas. Proc Natl Acad Sci U S A (2009) 3.25
EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer Cell (2012) 3.19
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell (2005) 3.15
Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development (2011) 3.11
Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev (2006) 3.09
Notch signaling controls liver development by regulating biliary differentiation. Development (2009) 2.93
Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration. J Clin Invest (2007) 2.92
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. J Clin Invest (2010) 2.90
Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol (2007) 2.87
Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia. Gastroenterology (2012) 2.74
Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology (2008) 2.71
EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. Cancer Cell (2012) 2.59
The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia. Proc Natl Acad Sci U S A (2007) 2.18
Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2009) 2.17
PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network. Cancer Discov (2011) 2.14
Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras. Biochem Biophys Res Commun (2009) 2.04
The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade. Dev Biol (2003) 1.94
Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors. Dev Cell (2010) 1.90
The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice. Cancer Res (2003) 1.89
Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia. Gastroenterology (2009) 1.89
Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology (1999) 1.88
Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN. Cancer Cell (2007) 1.86
Stabilization of beta-catenin induces pancreas tumor formation. Gastroenterology (2008) 1.81
A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol (2008) 1.79
Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia. Gastroenterology (2009) 1.78
Molecular genetics of pancreatic intraepithelial neoplasia. J Hepatobiliary Pancreat Surg (2007) 1.74
Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia. Oncogene (2012) 1.48
A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation. Development (2012) 1.39
Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model. PLoS One (2011) 1.38
Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas. Mech Dev (2004) 1.31
Sox9b is a key regulator of pancreaticobiliary ductal system development. PLoS Genet (2012) 1.30
Activated Notch1 target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitors. PLoS One (2010) 1.30
SOX9cre1, a cis-acting regulatory element located 1.1 Mb upstream of SOX9, mediates its enhancement through the SHH pathway. Hum Mol Genet (2007) 1.29
Notch1-induced mammary tumor development is cyclin D1-dependent and correlates with expansion of pre-malignant multipotent duct-limited progenitors. Oncogene (2010) 1.25
Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer. Carcinogenesis (2012) 1.20
Notch and Kras in pancreatic cancer: at the crossroads of mutation, differentiation and signaling. Cell Cycle (2009) 1.20
The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis. Proc Natl Acad Sci U S A (2012) 1.14
Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia. Gut (2012) 1.14
The group E Sox genes Sox8 and Sox9 are regulated by Notch signaling and are required for Müller glial cell development in mouse retina. Exp Eye Res (2009) 1.06
Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration. Dev Biol (2012) 1.06
Notch1 signaling regulates chondrogenic lineage determination through Sox9 activation. Cell Death Differ (2011) 0.94
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res (2004) 16.51
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell (2003) 15.43
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun (2006) 10.69
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature (2003) 10.33
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet (2002) 8.28
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet (2010) 6.81
Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer (2003) 4.86
Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells. Nat Cell Biol (2011) 4.77
Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet (2002) 4.76
Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol (2009) 4.73
Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations. Acta Neuropathol (2008) 4.73
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev (2009) 4.21
SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A (2007) 4.19
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A (2005) 4.15
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest (2002) 4.05
Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development (2005) 3.57
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression. Cancer Cell (2011) 3.47
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer (2010) 3.27
Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis (2002) 3.21
Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells. Gastroenterology (2011) 3.19
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev (2006) 3.16
Pancreas organogenesis: from bud to plexus to gland. Dev Dyn (2011) 3.14
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Ann Neurol (2008) 3.13
Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development (2011) 3.11
Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev (2006) 3.09
Prion-like spreading of pathological α-synuclein in brain. Brain (2013) 2.92
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. J Clin Invest (2010) 2.90
Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem (2002) 2.87
Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron (2005) 2.66
Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci U S A (2003) 2.64
A high-fat, ketogenic diet induces a unique metabolic state in mice. Am J Physiol Endocrinol Metab (2007) 2.64
Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci U S A (2007) 2.61
Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. J Clin Invest (2011) 2.54
Stabilization of beta-catenin impacts pancreas growth. Development (2006) 2.44
Common activation of canonical Wnt signaling in pancreatic adenocarcinoma. PLoS One (2007) 2.26
Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud. Dev Cell (2008) 2.25
TDP-43 is deposited in the Guam parkinsonism-dementia complex brains. Brain (2007) 2.25
Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43. Hum Mol Genet (2009) 2.23
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab (2012) 2.22
Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest (2007) 2.20
Inactivation of specific β cell transcription factors in type 2 diabetes. J Clin Invest (2013) 2.18
Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci U S A (2007) 2.17
Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes Dev (2011) 2.17
Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev (2006) 2.15
The MafA transcription factor appears to be responsible for tissue-specific expression of insulin. Proc Natl Acad Sci U S A (2004) 2.14
Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition. Genes Dev (2013) 2.12
Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling. Neuron (2005) 2.12
Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development (2006) 2.09
Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A (2009) 2.09
Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells. PLoS One (2007) 2.08
NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas. Development (2005) 2.03
Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies. Acta Neuropathol (2009) 2.01
Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice. Am J Physiol Endocrinol Metab (2008) 1.96
Pdx1 restores beta cell function in Irs2 knockout mice. J Clin Invest (2002) 1.95
Expanded RNA-binding activities of mammalian Argonaute 2. Nucleic Acids Res (2009) 1.94
Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors. Dev Cell (2010) 1.90
Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn. Development (2005) 1.90
Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase. Genesis (2005) 1.90
Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies. Exp Neurol (2007) 1.89
Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis. Gastroenterology (2009) 1.86
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development (2013) 1.83
Stabilization of beta-catenin induces pancreas tumor formation. Gastroenterology (2008) 1.81
A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol (2008) 1.79
Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. Cell Stem Cell (2013) 1.79
Submandibular gland biopsy for the diagnosis of Parkinson disease. J Neuropathol Exp Neurol (2013) 1.77
Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis. Gastroenterology (2006) 1.77
Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. Genes Dev (2006) 1.76
Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS. FEBS Lett (2008) 1.76
How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited. Diabetes (2011) 1.74
Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development (2004) 1.73
Context-specific α- to-β-cell reprogramming by forced Pdx1 expression. Genes Dev (2011) 1.69
A combinatorial strategy for treating KRAS-mutant lung cancer. Nature (2016) 1.69
Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice. Hepatology (2006) 1.69
pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol (2007) 1.68
Regulated beta-cell regeneration in the adult mouse pancreas. Diabetes (2007) 1.67
Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol (2008) 1.67
Telomerase gene mutations are associated with cirrhosis formation. Hepatology (2011) 1.67
Pancreatic development and disease. Gastroenterology (2007) 1.62
Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit. Cell (2009) 1.59
Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut (2013) 1.58
Cellular plasticity within the pancreas--lessons learned from development. Dev Cell (2010) 1.58
Positive regulation of adult bone formation by osteoblast-specific transcription factor osterix. J Bone Miner Res (2009) 1.56
Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells. Cell Rep (2013) 1.55
The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells. Development (2007) 1.54
Parathyroid carcinoma, atypical parathyroid adenoma, or parathyromatosis? Cancer (2007) 1.52
Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass. J Bone Miner Res (2008) 1.52
Canonical wnt signaling is required for pancreatic carcinogenesis. Cancer Res (2013) 1.49
Prion-like properties of pathological TDP-43 aggregates from diseased brains. Cell Rep (2013) 1.49
Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J Clin Invest (2006) 1.48
Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus. Dev Biol (2004) 1.47