Soluble guanylate cyclase is required for systemic vasodilation but not positive inotropy induced by nitroxyl in the mouse.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 25452469)

Published in Hypertension on December 01, 2014

Authors

Guangshuo Zhu1, Dieter Groneberg1, Gautam Sikka1, Daijiro Hori1, Mark J Ranek1, Taishi Nakamura1, Eiki Takimoto1, Nazareno Paolocci1, Dan E Berkowitz1, Andreas Friebe1, David A Kass2

Author Affiliations

1: From the Department of Medicine, Division of Cardiology, Johns Hopkins School of Medicine, Baltimore MD (G.Z., M.J.R., T.N., E.T., N.P., D.A.K.); Institut of Vegetative Physiology, Julius Maximilians-Universität Würzburg, Würzburg, Germany (D.G., A.F.); and Departments of Anesthesia (G.S., D.E.B.) and Surgery (D.H.), Johns Hopkins Medical Institutions, Baltimore MD.
2: From the Department of Medicine, Division of Cardiology, Johns Hopkins School of Medicine, Baltimore MD (G.Z., M.J.R., T.N., E.T., N.P., D.A.K.); Institut of Vegetative Physiology, Julius Maximilians-Universität Würzburg, Würzburg, Germany (D.G., A.F.); and Departments of Anesthesia (G.S., D.E.B.) and Surgery (D.H.), Johns Hopkins Medical Institutions, Baltimore MD. dkass@jhmi.edu.

Associated clinical trials:

A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure | NCT02157506

Articles cited by this

Cysteine redox sensor in PKGIa enables oxidant-induced activation. Science (2007) 3.29

Regulation of cardiac contractile function by troponin I phosphorylation. Cardiovasc Res (2005) 2.79

Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation. Circulation (2007) 2.46

Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase. Proc Natl Acad Sci U S A (2007) 2.24

Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway. Circ Res (2005) 1.91

Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from beta-adrenergic signaling. Proc Natl Acad Sci U S A (2003) 1.76

Cross-talk between cardiac muscle and coronary vasculature. Physiol Rev (2006) 1.72

Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system. J Clin Invest (2006) 1.69

Activation of distinct cAMP-dependent and cGMP-dependent pathways by nitric oxide in cardiac myocytes. Circ Res (1999) 1.67

Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling. Proc Natl Acad Sci U S A (2001) 1.63

Inhibition of soluble guanylate cyclase by ODQ. Biochemistry (2000) 1.58

Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling. Circ Res (2006) 1.56

Role of cyclic GMP-dependent protein kinase in the contractile response to exogenous nitric oxide in rat cardiac myocytes. J Physiol (2002) 1.54

The pharmacological activity of nitroxyl: a potent vasodilator with activity similar to nitric oxide and/or endothelium-derived relaxing factor. J Pharmacol Exp Ther (1992) 1.48

Comparison of ventricular pressure relaxation assessments in human heart failure: quantitative influence on load and drug sensitivity analysis. J Am Coll Cardiol (1999) 1.48

Bioassay discrimination between nitric oxide (NO.) and nitroxyl (NO-) using L-cysteine. Biochem Biophys Res Commun (1994) 1.47

The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3,-a] quinoxalin-1-one is a nonselective heme protein inhibitor of nitric oxide synthase and other cytochrome P-450 enzymes involved in nitric oxide donor bioactivation. Mol Pharmacol (1999) 1.42

cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation. Am J Physiol Heart Circ Physiol (2000) 1.34

NO- activates soluble guanylate cyclase and Kv channels to vasodilate resistance arteries. Hypertension (2003) 1.33

Calcium cycling and contractile activation in intact mouse cardiac muscle. J Physiol (1998) 1.32

Nitroxyl anion donor, Angeli's salt, does not develop tolerance in rat isolated aortae. Hypertension (2007) 1.31

Nitroxyl increases force development in rat cardiac muscle. J Physiol (2007) 1.30

cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes. Circ Res (2011) 1.29

Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo. J Med Chem (2005) 1.26

Mouse isolated perfused heart: characteristics and cautions. Clin Exp Pharmacol Physiol (2003) 1.26

The nitroxyl anion (HNO) is a potent dilator of rat coronary vasculature. Cardiovasc Res (2006) 1.24

Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension. Nat Med (2012) 1.23

Nitroxyl activates SERCA in cardiac myocytes via glutathiolation of cysteine 674. Circ Res (2009) 1.22

PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation. Basic Res Cardiol (2010) 1.21

Vascular smooth muscle relaxation mediated by nitric oxide donors: a comparison with acetylcholine, nitric oxide and nitroxyl ion. Br J Pharmacol (2001) 1.20

A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries. Br J Pharmacol (2009) 1.16

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway. Nat Commun (2014) 1.16

Phospholamban thiols play a central role in activation of the cardiac muscle sarcoplasmic reticulum calcium pump by nitroxyl. Biochemistry (2008) 1.16

Reduction of obesity, as induced by leptin, reverses endothelial dysfunction in obese (Lep(ob)) mice. J Appl Physiol (1985) (2000) 1.14

Pressure-volume relation analysis of mouse ventricular function. Am J Physiol Heart Circ Physiol (2011) 1.10

HNO and NO release from a primary amine-based diazeniumdiolate as a function of pH. Inorg Chem (2011) 1.10

The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems. Antioxid Redox Signal (2011) 1.04

The chemistry of nitroxyl-releasing compounds. Antioxid Redox Signal (2011) 1.02

Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function. Circ Res (2012) 1.02

Mechanisms underlying activation of soluble guanylate cyclase by the nitroxyl donor Angeli's salt. Mol Pharmacol (2009) 0.93

A comparison of the chemistry associated with the biological signaling and actions of nitroxyl (HNO) and nitric oxide (NO). J Inorg Biochem (2012) 0.88

A novel role for HNO in local and spreading vasodilatation in rat mesenteric resistance arteries. Antioxid Redox Signal (2010) 0.87

HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization. Antioxid Redox Signal (2013) 0.86

Nitroxyl (HNO): A novel approach for the acute treatment of heart failure. Circ Heart Fail (2013) 0.84

Detecting disulfide-bound complexes and the oxidative regulation of cyclic nucleotide-dependent protein kinases by H2O2. Methods Enzymol (2013) 0.84

The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and β-adrenergically desensitized ventricular myocytes. Biochem Biophys Res Commun (2010) 0.83

Endothelium-dependent nitroxyl-mediated relaxation is resistant to superoxide anion scavenging and preserved in diabetic rat aorta. Pharmacol Res (2012) 0.83

Vasorelaxant and antiaggregatory actions of the nitroxyl donor isopropylamine NONOate are maintained in hypercholesterolemia. Am J Physiol Heart Circ Physiol (2011) 0.81

HNO/cGMP-dependent antihypertrophic actions of isopropylamine-NONOate in neonatal rat cardiomyocytes: potential therapeutic advantages of HNO over NO. Am J Physiol Heart Circ Physiol (2013) 0.80

The trans effect of nitroxyl (HNO) in ferrous heme systems: implications for soluble guanylate cyclase activation by HNO. J Inorg Biochem (2012) 0.79

The concomitant coronary vasodilator and positive inotropic actions of the nitroxyl donor Angeli's salt in the intact rat heart: contribution of soluble guanylyl cyclase-dependent and -independent mechanisms. Br J Pharmacol (2014) 0.78

Nitrite- and nitroxyl-induced relaxation in porcine coronary (micro-) arteries: underlying mechanisms and role as endothelium-derived hyperpolarizing factor(s). Pharmacol Res (2012) 0.76