Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation.

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Published in PLoS Pathog on December 11, 2014

Authors

Alexandra Schuetz1, Claire Deleage2, Irini Sereti3, Rungsun Rerknimitr4, Nittaya Phanuphak5, Yuwadee Phuang-Ngern6, Jacob D Estes2, Netanya G Sandler7, Suchada Sukhumvittaya6, Mary Marovich8, Surat Jongrakthaitae6, Siriwat Akapirat6, James L K Fletscher9, Eugene Kroon10, Robin Dewar11, Rapee Trichavaroj6, Nitiya Chomchey5, Daniel C Douek7, Robert J O Connell6, Viseth Ngauy6, Merlin L Robb12, Praphan Phanuphak13, Nelson L Michael8, Jean-Louis Excler12, Jerome H Kim14, Mark S de Souza10, Jintanat Ananworanich15, RV254/SEARCH 010 and RV304/SEARCH 013 Study Groups

Author Affiliations

1: Department of Retrovirology, Armed Forces Research Institute of Medical Sciences - United States Component, Bangkok, Thailand; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
2: AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory of Cancer Research, Frederick, Maryland, United States of America.
3: Clinical and Molecular Retrovirology Section/Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
4: Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
5: SEARCH, Bangkok, Thailand; The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
6: Department of Retrovirology, Armed Forces Research Institute of Medical Sciences - United States Component, Bangkok, Thailand.
7: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
8: U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
9: SEARCH, Bangkok, Thailand.
10: Department of Retrovirology, Armed Forces Research Institute of Medical Sciences - United States Component, Bangkok, Thailand; SEARCH, Bangkok, Thailand.
11: Virus Isolation and Serology Laboratory Applied and Developmental Research Directorate Science Applications International Corporation, Frederick, Inc. National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland, United States of America.
12: Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
13: Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; SEARCH, Bangkok, Thailand; The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
14: SEARCH, Bangkok, Thailand; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
15: Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America; SEARCH, Bangkok, Thailand; The Thai Red Cross AIDS Research Centre, Bangkok, Thailand; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.

Associated clinical trials:

Establish and Characterize an Acute HIV Infection Cohort in a High Risk Population | NCT00796146

Antiretroviral Therapy for Acute HIV Infection (AAHIV) | NCT00796263

Characteristics of Immune Cells in Gut Mucosa of HIV Negative and HIV Positive Thais | NCT01397669

Efficacy of VHM After Treatment Interruption in Subjects Initiating ART During Acute HIV Infection | NCT02475915

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