Published in Science on August 03, 2007
Confronting the scientific obstacles to global control of tuberculosis. J Clin Invest (2008) 4.41
Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc Natl Acad Sci U S A (2008) 3.40
Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog (2009) 3.35
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. J Immunol (2009) 2.87
DC activated via dectin-1 convert Treg into IL-17 producers. Eur J Immunol (2008) 1.99
In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J Exp Med (2008) 1.91
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes (2009) 1.88
Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation. Immunol Rev (2008) 1.88
Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease. Blood (2009) 1.57
New directions in the basic and translational biology of interleukin-27. Trends Immunol (2011) 1.54
CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2. Proc Natl Acad Sci U S A (2009) 1.52
The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal (2012) 1.47
Th17 and regulatory T cells: implications for AIDS pathogenesis. Curr Opin HIV AIDS (2010) 1.45
Depletion of Regulatory T Cells Induces High Numbers of Dendritic Cells and Unmasks a Subset of Anti-Tumour CD8+CD11c+ PD-1lo Effector T Cells. PLoS One (2016) 1.40
Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation. PLoS Pathog (2014) 1.30
Functional analysis of effector and regulatory T cells in a parasitic nematode infection. Infect Immun (2008) 1.25
Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites. PLoS One (2010) 1.23
Microanatomy of the liver immune system. Semin Immunopathol (2009) 1.22
A role for IL-27 in limiting T regulatory cell populations. J Immunol (2011) 1.17
Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells. Immunology (2009) 1.16
Plasmodium falciparum-mediated induction of human CD25Foxp3 CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFbeta. PLoS Pathog (2009) 1.14
Loss of intra-islet CD20 expression may complicate efficacy of B-cell-directed type 1 diabetes therapies. Diabetes (2011) 1.12
Th 17 cells interplay with Foxp3+ Tregs in regulation of inflammation and autoimmunity. Front Biosci (Landmark Ed) (2010) 1.11
Regulatory T-cell status in red cell alloimmunized responder and nonresponder mice. Blood (2009) 1.09
Redox remodeling as an immunoregulatory strategy. Biochemistry (2010) 1.08
Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease. J Exp Med (2009) 1.06
Potential plasticity of T regulatory cells in pancreatic carcinoma in relation to disease progression and outcome. Exp Ther Med (2012) 1.04
The immunomodulatory and neuroprotective effects of mesenchymal stem cells (MSCs) in experimental autoimmune encephalomyelitis (EAE): a model of multiple sclerosis (MS). Int J Mol Sci (2012) 1.02
Effective anti-neu-initiated antitumor responses require the complex role of CD4+ T cells. Clin Cancer Res (2013) 1.02
Suppression of regulatory T cells by IL-12p40 homodimer via nitric oxide. J Immunol (2009) 1.01
Making sense of regulatory T cell suppressive function. Semin Immunol (2011) 1.00
TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses. Nat Commun (2015) 0.99
Regulation of TGFβ in the immune system: an emerging role for integrins and dendritic cells. Immunobiology (2012) 0.99
Protection of Tregs, suppression of Th1 and Th17 cells, and amelioration of experimental allergic encephalomyelitis by a physically-modified saline. PLoS One (2012) 0.97
Myelin basic protein priming reduces the expression of Foxp3 in T cells via nitric oxide. J Immunol (2010) 0.97
Profile of central and effector memory T cells in the progression of chronic human chagas disease. PLoS Negl Trop Dis (2009) 0.96
MHC class II antigen presentation and immunological abnormalities due to deficiency of MHC class II and its associated genes. Exp Mol Pathol (2008) 0.95
Cellular mediators of inflammation: tregs and TH17 cells in gastrointestinal diseases. Mediators Inflamm (2010) 0.94
Induction of CD4(+)CD25(+)FOXP3(+) regulatory T cells during human hookworm infection modulates antigen-mediated lymphocyte proliferation. PLoS Negl Trop Dis (2011) 0.93
Interleukin-2/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin-2/STAT5 signalling pathways. Immunology (2012) 0.93
Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth. J Immunol (2011) 0.92
T-cell regulation by CD46 and its relevance in multiple sclerosis. Immunology (2008) 0.92
Hsp65-producing Lactococcus lactis prevents experimental autoimmune encephalomyelitis in mice by inducing CD4+LAP+ regulatory T cells. J Autoimmun (2012) 0.90
Human visceral leishmaniasis is not associated with expansion or accumulation of Foxp3+ CD4 cells in blood or spleen. Parasite Immunol (2010) 0.89
Immunotherapy for hepatocellular carcinoma: From basic research to clinical use. World J Hepatol (2015) 0.88
Cisplatin pretreatment enhances anti-tumor activity of cytokine-induced killer cells. World J Gastroenterol (2011) 0.88
Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells--how diverse signals regulate suppression. Immunology (2008) 0.86
CD4+ CD25+ but not CD4+ Foxp3+ T cells as a regulatory subset in primary biliary cirrhosis. Cell Mol Immunol (2010) 0.85
Relationship of regulatory T cells to Plasmodium falciparum malaria symptomatology in a hypoendemic region. Malar J (2014) 0.84
SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression. Nat Commun (2015) 0.83
The interaction between regulatory T cells and NKT cells in the liver: a CD1d bridge links innate and adaptive immunity. PLoS One (2011) 0.83
Liver accumulation of Plasmodium chabaudi-infected red blood cells and modulation of regulatory T cell and dendritic cell responses. PLoS One (2013) 0.83
Genetic evidence of regulatory gene variants of the STAT6, IL10R and FOXP3 locus as a susceptibility factor in uncomplicated malaria and parasitaemia in Congolese children. Malar J (2013) 0.83
Identification of cytolytic CD161- CD56+ regulatory CD8 T cells in human peripheral blood. PLoS One (2013) 0.82
Regulatory T cells suppress the late phase of the immune response in lymph nodes through P-selectin glycoprotein ligand-1. J Immunol (2013) 0.82
Loss of balance between T helper type 17 and regulatory T cells in chronic human immunodeficiency virus infection. Clin Exp Immunol (2011) 0.82
Haematological parameters, natural regulatory CD4 + CD25 + FOXP3+ T cells and γδ T cells among two sympatric ethnic groups having different susceptibility to malaria in Burkina Faso. BMC Res Notes (2012) 0.82
The imbalance between Tregs, Th17 cells and inflammatory cytokines among renal transplant recipients. BMC Immunol (2015) 0.82
Blimp-1 connects the intrinsic and extrinsic regulation of T cell homeostasis. J Clin Immunol (2007) 0.80
Alterations in regulatory T-cells: rediscovered pathways in immunotoxicology. J Immunotoxicol (2011) 0.79
Correlations between psoriasis and inflammatory bowel diseases. Biomed Res Int (2013) 0.79
Selenium and asthma. Mol Aspects Med (2011) 0.79
Influence of maternal immunization with allergens on the thymic maturation of lymphocytes with regulatory potential in children: a broad field for further exploration. J Immunol Res (2014) 0.78
Inhibition of S-phase kinase-associated protein 2 (Skp2) reprograms and converts diabetogenic T cells to Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2012) 0.77
3-Hydroxy kynurenine treatment controls T. cruzi replication and the inflammatory pathology preventing the clinical symptoms of chronic Chagas disease. PLoS One (2011) 0.76
Cell penetrating recombinant Foxp3 protein enhances Treg function and ameliorates arthritis. Biochem Biophys Res Commun (2013) 0.76
Development of T-cell tolerance utilizes both cell-autonomous and cooperative presentation of self-antigen. Immunol Rev (2016) 0.76
Decreased Expression of Vitamin D Receptor Affects an Immune Response in Primary Biliary Cholangitis via the VDR-miRNA155-SOCS1 Pathway. Int J Mol Sci (2017) 0.76
T-Regulatory Cells and Vaccination "Pay Attention and Do Not Neglect Them": Lessons from HIV and Cancer Vaccine Trials. Vaccines (Basel) (2016) 0.75
Short-term intratracheal use of PEG-modified IL-2 and glucocorticoid persistently alleviates asthma in a mouse model. Sci Rep (2016) 0.75
Apoptotic cell-linked immunoregulation: implications for promoting immune tolerance in transplantation. Cell Biosci (2015) 0.75
Cancer cell-derived IL-1α induces CCL22 and the recruitment of regulatory T cells. Oncoimmunology (2016) 0.75
Thymic and Postthymic Regulation of Naïve CD4(+) T-Cell Lineage Fates in Humans and Mice Models. Mediators Inflamm (2016) 0.75
T-cell signaling and immunopathologies. Semin Immunopathol (2010) 0.75
Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection. Front Immunol (2017) 0.75
Host immune response is severely compromised during lethal Plasmodium vinckei infection. Parasitol Res (2015) 0.75
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med (2007) 15.17
Innate lymphoid cells--a proposal for uniform nomenclature. Nat Rev Immunol (2013) 7.94
Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med (2006) 7.76
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature (2010) 6.44
Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature (2011) 6.43
CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med (2003) 6.00
Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol (2003) 5.94
IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J Exp Med (2006) 5.76
Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur J Immunol (2005) 5.43
Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity (2006) 5.40
Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J Exp Med (2005) 4.47
Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol Rev (2006) 4.40
T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med (2005) 4.28
Dendritic cells in intestinal immune regulation. Nat Rev Immunol (2008) 4.20
Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis. J Immunol (2006) 4.04
Regulatory T cells and intestinal homeostasis. Immunol Rev (2005) 3.82
Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol (2009) 3.80
Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med (2008) 3.74
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity (2010) 3.52
Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity (2010) 3.51
Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. J Immunol (2006) 3.42
Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. Immunity (2008) 3.40
Regulatory T cells reinforce intestinal homeostasis. Immunity (2009) 3.27
E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. Immunity (2010) 2.78
IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J Exp Med (2011) 2.74
Dysregulated hematopoietic stem and progenitor cell activity promotes interleukin-23-driven chronic intestinal inflammation. Immunity (2012) 2.72
Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. J Exp Med (2013) 2.50
IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells. J Exp Med (2012) 2.11
Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10. J Immunol (2003) 2.08
The interleukin-23 axis in intestinal inflammation. Immunol Rev (2008) 2.06
Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease. Gastroenterology (2010) 2.01
Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens. Eur J Immunol (2002) 1.88
Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells. Blood (2011) 1.83
Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. Cancer Immun (2002) 1.80
Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells. Inflamm Bowel Dis (2007) 1.73
Microbiota, disease, and back to health: a metastable journey. Sci Transl Med (2012) 1.70
OX40 is required for regulatory T cell-mediated control of colitis. J Exp Med (2010) 1.62
Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection. Blood (2012) 1.60
Involvement of innate immunity in the development of inflammatory and autoimmune diseases. Ann N Y Acad Sci (2005) 1.59
The IL23 axis plays a key role in the pathogenesis of IBD. Gut (2007) 1.58
A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3. Blood (2014) 1.58
TLR2-independent induction and regulation of chronic intestinal inflammation. Eur J Immunol (2010) 1.55
Regulatory T cells. Curr Opin Pharmacol (2004) 1.52
Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells. Eur J Immunol (2010) 1.47
An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer. J Exp Med (2010) 1.42
Fueling regulation: IL-2 keeps CD4+ Treg cells fit. Nat Immunol (2005) 1.30
Cure of innate intestinal immune pathology by CD4+CD25+ regulatory T cells. Immunol Lett (2005) 1.20
CD4(+) T-cell subsets in intestinal inflammation. Immunol Rev (2013) 1.17
Dendritic cells and the intestinal bacterial flora: a role for localized mucosal immune responses. J Clin Invest (2003) 1.14
Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier. Immunology (2008) 1.12
Lymphoid microenvironments and innate lymphoid cells in the gut. Trends Immunol (2012) 1.08
Re-establishing immunological self-tolerance in autoimmune disease. Nat Med (2012) 1.06
Mouse models of intestinal inflammation as tools to understand the pathogenesis of inflammatory bowel disease. Eur J Immunol (2009) 1.04
Interleukin-10 in the regulation of T cell-induced colitis. J Autoimmun (2003) 0.99
CTLA-4 expression on antigen-specific cells but not IL-10 secretion is required for oral tolerance. Eur J Immunol (2002) 0.98
Homeostasis of intestinal immune regulation. Microbes Infect (2002) 0.96
Immunology: Dendritic-cell genealogy. Nature (2009) 0.96
Hybrid Treg cells: steel frames and plastic exteriors. Nat Immunol (2009) 0.92
Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development. J Immunol (2007) 0.89
The role of mucosal T lymphocytes in regulating intestinal inflammation. Springer Semin Immunopathol (2005) 0.85
Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2. J Immunol (2013) 0.85
Immunology. The gut's Clostridium cocktail. Science (2011) 0.84
Gpr83 expression is not required for the maintenance of intestinal immune homeostasis and regulation of T-cell-dependent colitis. Immunology (2008) 0.84
Prenatal tolerance--a role for regulatory T cells? Eur J Immunol (2005) 0.82
Thymic generation and selection of CD25+CD4+ regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance. Novartis Found Symp (2003) 0.82
Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A. Vaccine (2012) 0.81
Immunology. Feed your Tregs more fiber. Science (2013) 0.80
Regulatory mechanisms in graft-versus-host responses. Biol Blood Marrow Transplant (2009) 0.77
Homing of intestinal immune cells. Novartis Found Symp (2004) 0.76
Immunology: Malnutrition promotes rogue bacteria. Nature (2012) 0.76
Fiona Powrie: Gut diplomacy. Interview by Amy Maxmen. J Exp Med (2010) 0.75
Gender equality: is it real? Eur J Immunol (2012) 0.75
Erratum: Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease. Nat Med (2017) 0.75