Circulating tumor DNA analysis as a real-time method for monitoring tumor burden in melanoma patients undergoing treatment with immune checkpoint blockade.

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Published in J Immunother Cancer on December 16, 2014

Authors

Evan J Lipson1, Victor E Velculescu1, Theresa S Pritchard2, Mark Sausen3, Drew M Pardoll1, Suzanne L Topalian2, Luis A Diaz4

Author Affiliations

1: Department of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD USA.
2: Department of Surgery, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD USA.
3: Personal Genome Diagnostics, Baltimore, MD USA.
4: Department of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD USA ; Ludwig Center for Cancer Genetics and Therapeutics and the Swim Across America Laboratory, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD USA.

Associated clinical trials:

Multiple Ascending Dose (MDX1105-01) (Anti-PDL1) | NCT00729664

Early Detection of Four Common Cancers Using the ctDNA Analysing Test (K-DETEK) | NCT05227261

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