Published in Exp Cell Res on September 01, 1989
A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89
The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol (2010) 7.58
Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol Cell Biol (2000) 3.37
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat Cell Biol (2008) 2.81
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol (1999) 2.64
Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev (2010) 2.32
Senescence in human intervertebral discs. Eur Spine J (2006) 2.00
Telomeres shorten more slowly in long-lived birds and mammals than in short-lived ones. Proc Biol Sci (2003) 1.81
Cataloging altered gene expression in young and senescent cells using enhanced differential display. Nucleic Acids Res (1995) 1.36
Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel Mdm2/p53-mediated pathway. Cancer Res (2009) 1.36
Cellular senescence, ageing and disease. Age (Dordr) (2008) 1.17
Physiological and pathological consequences of cellular senescence. Cell Mol Life Sci (2014) 1.15
Astrocyte senescence as a component of Alzheimer's disease. PLoS One (2012) 1.11
Dissociation of Oct-1 from the nuclear peripheral structure induces the cellular aging-associated collagenase gene expression. Mol Biol Cell (1997) 1.10
Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts. Mol Cell Biol (1997) 1.08
Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1. Mol Cell Biol (2002) 1.01
Cellular Senescence - its role in cancer and the response to ionizing radiation. Genome Integr (2011) 0.98
Aging alters functionally human dermal papillary fibroblasts but not reticular fibroblasts: a new view of skin morphogenesis and aging. PLoS One (2008) 0.97
Pathophysiology of degenerative disc disease. Asian Spine J (2009) 0.94
MicroRNA-152 and -181a participate in human dermal fibroblasts senescence acting on cell adhesion and remodeling of the extra-cellular matrix. Aging (Albany NY) (2012) 0.92
From heterochromatin islands to the NAD World: a hierarchical view of aging through the functions of mammalian Sirt1 and systemic NAD biosynthesis. Biochim Biophys Acta (2009) 0.92
A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion. Mol Cancer Res (2008) 0.91
Collagen extracts derived from young and aged mice demonstrate different structural properties and cellular effects in three-dimensional gels. J Gerontol A Biol Sci Med Sci (2010) 0.91
Caveolin-1, cellular senescence and age-related diseases. Mech Ageing Dev (2011) 0.90
Loss of serum response element-binding activity and hyperphosphorylation of serum response factor during cellular aging. Mol Cell Biol (1994) 0.90
Low-dose radiation-induced senescent stromal fibroblasts render nearby breast cancer cells radioresistant. Radiat Res (2009) 0.88
Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence. Redox Biol (2016) 0.86
Oxidative stress-induced inhibition of Sirt1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6). J Biol Chem (2014) 0.85
Changes in the Secretory Profile of NSCLC-Associated Fibroblasts after Ablative Radiotherapy: Potential Impact on Angiogenesis and Tumor Growth. Transl Oncol (2013) 0.85
Immortalization-susceptible elements and their binding factors mediate rejuvenation of regulation of the type I collagenase gene in simian virus 40 large T antigen-transformed immortal human fibroblasts. Mol Cell Biol (1994) 0.85
Senescence and life span. Pflugers Arch (2009) 0.84
Cellular senescence: from growth arrest to immunogenic conversion. Age (Dordr) (2015) 0.82
Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells. Age (Dordr) (2012) 0.79
SNEV(P) (rp19/) (PSO) (4) deficiency increases PUVA-induced senescence in mouse skin. Exp Dermatol (2016) 0.77
Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases. Cancer Sci (2017) 0.75
Anti-aging and tyrosinase inhibition effects of Cassia fistula flower butanolic extract. BMC Complement Altern Med (2016) 0.75
Mechanism of immortalization. Age (Omaha) (1999) 0.75
Age-related dermal collagen changes during development, maturation and ageing - a morphometric and comparative study. J Anat (2014) 0.75
Soy protein isolate inhibits high-fat diet-induced senescence pathways in osteoblasts to maintain bone acquisition in male rats. Endocrinology (2014) 0.75
Senescence in the aging process. F1000Res (2017) 0.75
Modulation of non-templated nucleotide addition by Taq DNA polymerase: primer modifications that facilitate genotyping. Biotechniques (1996) 8.92
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res (1994) 6.16
A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res (1991) 4.07
Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts. Mol Cell Biol (1989) 3.89
CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein. Genes Dev (1996) 3.27
The excretion of histamine in urine. J Physiol (1944) 3.23
Prevalence of nonconvulsive status epilepticus in comatose patients. Neurology (2000) 2.86
Hydrogen ion buffers for biological research. Anal Biochem (1980) 2.84
Replicative senescence: implications for in vivo aging and tumor suppression. Science (1996) 2.83
Characteristics of prostate cancer in families potentially linked to the hereditary prostate cancer 1 (HPC1) locus. JAMA (1997) 2.73
Genetic analysis of indefinite division in human cells: evidence for a cell senescence-related gene(s) on human chromosome 4. Proc Natl Acad Sci U S A (1991) 2.64
Safety study of nonoxynol-9 as a vaginal microbicide: evidence of adverse effects. J Acquir Immune Defic Syndr Hum Retrovirol (1998) 2.41
Guidelines for the management of HIV infection in pregnant women and the prevention of mother-to-child transmission. HIV Med (2001) 2.33
Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proc Natl Acad Sci U S A (1988) 2.31
A gene involved in control of human cellular senescence on human chromosome 1q. Mol Cell Biol (1994) 2.26
NeuralWISP: A Wirelessly Powered Neural Interface With 1-m Range. IEEE Trans Biomed Circuits Syst (2009) 2.23
Genetic analysis of indefinite division in human cells: identification of four complementation groups. Proc Natl Acad Sci U S A (1988) 2.08
Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells. Mol Cell Biol (1991) 2.04
Non-specific urethritis associated with a tetracycline-resistant T-mycoplasma. Br J Vener Dis (1974) 2.01
Smokers' polycythemia. N Engl J Med (1978) 1.95
Evidence for the recessive nature of cellular immortality. Science (1983) 1.94
Molecular basis for impaired muscle differentiation in myotonic dystrophy. Mol Cell Biol (2001) 1.88
A giant sauropod dinosaur from an Upper Cretaceous mangrove deposit in Egypt. Science (2001) 1.78
Nature, time course and dose dependence of zidovudine-related side effects: results from the Multicenter Canadian Azidothymidine Trial. AIDS (1989) 1.78
Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular aging. Science (1980) 1.72
Analysis by high density cDNA arrays of altered gene expression in human intestinal epithelial cells in response to infection with the invasive enteric bacteria Salmonella. J Biol Chem (2000) 1.70
Entamoeba histolytica trophozoites induce an inflammatory cytokine response by cultured human cells through the paracrine action of cytolytically released interleukin-1 alpha. J Clin Invest (1995) 1.68
Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production. J Clin Invest (1997) 1.68
Use of corticosteroid sparing systemic immunosuppression for treatment of corticosteroid dependent optic neuritis not associated with demyelinating disease. Br J Ophthalmol (2004) 1.66
HIV and infertility: time to treat. There's no justification for denying treatment to parents who are HIV positive. BMJ (2001) 1.62
Antenatal serum screening for genital herpes: a study of knowledge and attitudes of women at a central London hospital. Br J Obstet Gynaecol (1997) 1.62
Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1. EMBO J (1995) 1.59
Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. Mol Cell Biol (1999) 1.57
Nitric oxide production by human intestinal epithelial cells and competition for arginine as potential determinants of host defense against the lumen-dwelling pathogen Giardia lamblia. J Immunol (2000) 1.56
Existence of high abundance antiproliferative mRNA's in senescent human diploid fibroblasts. Science (1986) 1.55
THE FLOW OF BLOOD IN THE CORONARY ARTERIES IN PATHOLOGICAL HEARTS. J Clin Invest (1938) 1.55
Isolation of a cDNA that hybrid selects antiproliferative mRNA from rat liver. Biochem Biophys Res Commun (1989) 1.54
The impact of child support on cognitive outcomes of young children. Demography (1998) 1.54
Expression of SV40 T antigen in finite life-span hybrids of normal and SV40-transformed fibroblasts. Somatic Cell Genet (1981) 1.53
Protein content in lymph and edema fluid in congestive heart failure. Circulation (1969) 1.50
Conservation of the MORF4 related gene family: identification of a new chromo domain subfamily and novel protein motif. Gene (2001) 1.49
Evidence for a p53-independent pathway for upregulation of SDI1/CIP1/WAF1/p21 RNA in human cells. Mol Carcinog (1994) 1.49
Fibroid embolisation: a technique not without significant complications. BJOG (2000) 1.46
Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation. Proc Natl Acad Sci U S A (1991) 1.44
Management of intracranial meningeal hemangiopericytomas: outcome and experience. Neurosurg Rev (2006) 1.44
An upper limit on the stochastic gravitational-wave background of cosmological origin. Nature (2009) 1.42
Observation of B(0)(s)-->Psi(2S)Phi and measurement of the ratio of branching fractions Beta(B(0)(s)-->Psi(2S)Phi)/Beta(B(0)(s)-->J/PsiPhi). Phys Rev Lett (2006) 1.40
Expression of angiotensin-converting enzyme activity in cultured pulmonary artery endothelial cells. J Cell Physiol (1981) 1.38
View 1: Assisted conception in couples with HIV infection. Sex Transm Infect (2003) 1.38
The molecular organisation of bimolecular lipid membranes. The dielectric structure of the hydrophilic/hydrophobic interface. Biochim Biophys Acta (1981) 1.37
Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein. Mol Cell Biol (1996) 1.37
The C-terminal region of p21SDI1/WAF1/CIP1 is involved in proliferating cell nuclear antigen binding but does not appear to be required for growth inhibition. J Biol Chem (1995) 1.37
Erythromycin ointment for ocular prophylaxis of neonatal chlamydial infection. JAMA (1980) 1.36
Toxicity assessment of sediments from the Grand Calumet River and Indiana Harbor Canal in Northwestern Indiana, USA. Arch Environ Contam Toxicol (2002) 1.31
Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA. Proc Natl Acad Sci U S A (1995) 1.31
Precision top-quark mass measurement at CDF. Phys Rev Lett (2012) 1.30
Safety and pharmacokinetics of oseltamivir at standard and high dosages. Int J Antimicrob Agents (2010) 1.29
Variation in the life-span of clones derived from human diploid cell strains. J Cell Biol (1974) 1.28
Early age at diagnosis in families providing evidence of linkage to the hereditary prostate cancer locus (HPC1) on chromosome 1. Cancer Res (1997) 1.27
Colony size distributions as a measure of in vivo and in vitro aging. Proc Natl Acad Sci U S A (1978) 1.27
Extramitochondrial localization of mortalin/mthsp70/PBP74/GRP75. Biochem Biophys Res Commun (2000) 1.26
Bone marrow transplantation in canine mucopolysaccharidosis I. Effects within the central nervous system. J Clin Invest (1987) 1.26
Measurement of the cross section for prompt isolated diphoton production using the full CDF run II data sample. Phys Rev Lett (2013) 1.22
An extended HLA-D region haplotype associated with celiac disease. Proc Natl Acad Sci U S A (1988) 1.21
The effectiveness of magnesium chloride in the treatment of ventricular tachyarrhythmias due to digitalis intoxication. Am Heart J (1974) 1.18
Evaluation of sperm washing as a potential method of reducing HIV transmission in HIV-discordant couples wishing to have children. AIDS (1999) 1.18
Bronchial asthma induced by indomethacin. Ann Intern Med (1967) 1.17
Congenital absence of superior vena cava: unusual anomaly of superior systemic veins complicating pacemaker placement. Pacing Clin Electrophysiol (1981) 1.17
Mitogenic effects of the proto-oncogene and oncogene forms of c-H-ras DNA in human diploid fibroblasts. Mol Cell Biol (1986) 1.17
MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14. J Biol Chem (2001) 1.16
Senescent and quiescent cell inhibitors of DNA synthesis. Membrane-associated proteins. Exp Cell Res (1985) 1.16
Wada memory testing and hippocampal volume measurements in the evaluation for temporal lobectomy. Neurology (1993) 1.15
Effects of local anesthetics on cell morphology and membrane-associated cytoskeletal organization in BALB/3T3 cells. J Cell Biol (1976) 1.15
Improved student learning in ophthalmology with computer-aided instruction. Eye (Lond) (2001) 1.15
Uterine fibroleiomyoma: MR imaging appearances before and after embolization of uterine arteries. Radiology (2000) 1.14
Photosensitization of human diploid cell cultures by intracellular flavins and protection by antioxidants. Photochem Photobiol (1976) 1.14
Septic arthritis, gout, pseudogout and osteoarthritis in the knee of a patient with multiple myeloma. Arthritis Rheum (1972) 1.14
Measurement of the WW + WZ production cross section using the lepton + jets final state at CDF II. Phys Rev Lett (2010) 1.12
First observation of the decay Bs0-->Ds-Ds+ and measurement of its branching ratio. Phys Rev Lett (2008) 1.11
Calcium signaling mechanisms in dedifferentiated cardiac myocytes: comparison with neonatal and adult cardiomyocytes. Cell Calcium (2001) 1.10
Phenotype of low proliferative potential is dominant in hybrids of normal human fibroblasts. Somatic Cell Genet (1982) 1.09
Re: economic evaluation of robot-assisted hysterectomy: a cost-minimisation analysis. BJOG (2015) 1.09
DNA methyltransferase inhibition in normal human fibroblasts induces a p21-dependent cell cycle withdrawal. J Biol Chem (2001) 1.09