Caveolin-1, cellular senescence and age-related diseases.

Blood CD33(+)HLA-DR(-) myeloid-derived suppressor cells are increased with age and a history of cancer. J Leukoc Biol (2013) 1.22

Berberine suppresses gero-conversion from cell cycle arrest to senescence. Aging (Albany NY) (2013) 0.98

Biochemical markers of aging for longitudinal studies in humans. Epidemiol Rev (2013) 0.87

Effects of Aging and Hypercholesterolemia on Oxidative Stress and DNA Damage in Bone Marrow Mononuclear Cells in Apolipoprotein E-deficient Mice. Int J Mol Sci (2013) 0.86

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases. Oxid Med Cell Longev (2016) 0.85

Loss of Epithelial Membrane Protein 2 Aggravates Podocyte Injury via Upregulation of Caveolin-1. J Am Soc Nephrol (2015) 0.83

Loss of caveolin-1 expression in knock-in mouse model of Huntington's disease suppresses pathophysiology in vivo. Hum Mol Genet (2013) 0.82

Increased caveolin-1 in intervertebral disc degeneration facilitates repair. Arthritis Res Ther (2016) 0.78

Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner. Exp Mol Med (2012) 0.78

The Natural Polyphenol Epigallocatechin Gallate Protects Intervertebral Disc Cells from Oxidative Stress. Oxid Med Cell Longev (2016) 0.77

Increased Oxidative and Nitrative Stress Accelerates Aging of the Retinal Vasculature in the Diabetic Retina. PLoS One (2015) 0.76

Differential responses of choroidal melanocytes and uveal melanoma cells to low oxygen conditions. Mol Vis (2017) 0.75

Redox mechanisms in age-related lung fibrosis. Redox Biol (2016) 0.75

Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular Dysfunction. Arterioscler Thromb Vasc Biol (2017) 0.75

A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13

Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20

The serial cultivation of human diploid cell strains. Exp Cell Res (1961) 25.11

Telomeres shorten during ageing of human fibroblasts. Nature (1990) 23.97

Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48

Aging: a theory based on free radical and radiation chemistry. J Gerontol (1956) 20.39

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13

Regulation of p53 stability by Mdm2. Nature (1997) 18.20

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell (1992) 16.53

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell (2005) 12.73

Putting tumours in context. Nat Rev Cancer (2001) 12.37

p53 mutant mice that display early ageing-associated phenotypes. Nature (2002) 10.05

Senescence of activated stellate cells limits liver fibrosis. Cell (2008) 8.98

Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol (2002) 6.68

Cellular senescence in aging primates. Science (2006) 6.24

Oxidant signals and oxidative stress. Curr Opin Cell Biol (2003) 5.67

Protein phosphatase 1--targeted in many directions. J Cell Sci (2002) 5.59

Cellular senescence: mitotic clock or culture shock? Cell (2000) 5.17

Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev (1998) 5.14

Oxyradicals and DNA damage. Carcinogenesis (2000) 4.87

Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis. Trends Cell Biol (1994) 4.87

VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles. J Cell Biol (1992) 4.81

The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle (2009) 4.69

Modulation of mammalian life span by the short isoform of p53. Genes Dev (2004) 4.52

Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. J Biol Chem (1996) 4.50

Low back pain in relation to lumbar disc degeneration. Spine (Phila Pa 1976) (2000) 4.39

Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem (1997) 4.12

Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem (1996) 3.62

Thioredoxin reductase. Biochem J (2000) 3.47

Evidence for a regulated interaction between heterotrimeric G proteins and caveolin. J Biol Chem (1995) 3.45

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol (2010) 3.29

Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms. Traffic (2003) 3.25

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle (2010) 3.15

An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers. Am J Pathol (2009) 3.15

Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev (2006) 3.14

Oligomeric structure of caveolin: implications for caveolae membrane organization. Proc Natl Acad Sci U S A (1995) 3.13

Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae. J Cell Biol (1994) 3.12

Emerging themes in lipid rafts and caveolae. Cell (2001) 3.09

VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro. Mol Biol Cell (1995) 3.05

Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity. J Biol Chem (1997) 3.02

Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. J Exp Med (2006) 2.92

Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci U S A (1995) 2.89

Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells. J Biol Chem (1996) 2.82

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene (1998) 2.81

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. Cell Cycle (2010) 2.80

The Caveolin genes: from cell biology to medicine. Ann Med (2004) 2.68

Cytokine production and inflammation drive autophagy in the tumor microenvironment: role of stromal caveolin-1 as a key regulator. Cell Cycle (2011) 2.68

Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity. Exp Cell Res (1989) 2.66

Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells. Oncogene (1998) 2.59

Extension of the life-span of human endothelial cells by an interleukin-1 alpha antisense oligomer. Science (1990) 2.59

Localization of epidermal growth factor-stimulated Ras/Raf-1 interaction to caveolae membrane. J Biol Chem (1996) 2.58

Protein oxidation. Ann N Y Acad Sci (2000) 2.57

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci U S A (1994) 2.55

Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities. J Biol Chem (1997) 2.52

The biology of replicative senescence. Eur J Cancer (1997) 2.42

Endothelial caveolae have the molecular transport machinery for vesicle budding, docking, and fusion including VAMP, NSF, SNAP, annexins, and GTPases. J Biol Chem (1995) 2.41

Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. Biochem J (1998) 2.41

Regulators of serine/threonine protein phosphatases at the dawn of a clinical era? Curr Med Chem (2002) 2.34

Genes involved in senescence and immortalization. Curr Opin Cell Biol (2000) 2.27

Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. EMBO J (1998) 2.23

Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. EMBO J (2004) 2.19

Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol (2002) 2.08

Protein kinase C activators inhibit receptor-mediated potocytosis by preventing internalization of caveolae. J Cell Biol (1994) 2.04

Senescence in human intervertebral discs. Eur Spine J (2006) 2.00

Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism. Mol Biol Cell (2001) 2.00

Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease. Proc Am Thorac Soc (2005) 1.99

Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening. Kidney Int (2003) 1.85

Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration. Arthritis Res Ther (2007) 1.85

Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy. Cancer Biol Ther (2008) 1.79

DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation. Mol Biol Cell (2006) 1.78

Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements. Cancer Res (2006) 1.73

Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J Biol Chem (2000) 1.71

Cigarette smoke induces cellular senescence. Am J Respir Cell Mol Biol (2006) 1.66

Mammalian selenium-containing proteins. Annu Rev Nutr (2001) 1.63

Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts. Exp Cell Res (1992) 1.62

Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. Cancer Res (1995) 1.61

Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice. J Biol Chem (2005) 1.59

Cellular senescence and cancer. J Pathol (1999) 1.57

Increased pulmonary vascular resistance and defective pulmonary artery filling in caveolin-1-/- mice. Am J Physiol Lung Cell Mol Physiol (2008) 1.56

Scleroderma-like properties of skin from caveolin-1-deficient mice: implications for new treatment strategies in patients with fibrosis and systemic sclerosis. Cell Cycle (2011) 1.52

A potential role for skeletal muscle caveolin-1 as an insulin sensitivity modulator in ageing-dependent non-obese type 2 diabetes: studies in a new mouse model. Diabetologia (2008) 1.52

Mutational analysis of the properties of caveolin-1. A novel role for the C-terminal domain in mediating homo-typic caveolin-caveolin interactions. J Biol Chem (1997) 1.51

Telomere erosion and senescence in human articular cartilage chondrocytes. J Gerontol A Biol Sci Med Sci (2001) 1.50

Senescence in cells of the aging and degenerating intervertebral disc: immunolocalization of senescence-associated beta-galactosidase in human and sand rat discs. Spine (Phila Pa 1976) (2007) 1.46

Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts. Mol Biol Cell (2002) 1.45

Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells. J Biol Chem (2000) 1.40

Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel Mdm2/p53-mediated pathway. Cancer Res (2009) 1.36

Cataloging altered gene expression in young and senescent cells using enhanced differential display. Nucleic Acids Res (1995) 1.36

The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts. J Biol Chem (2001) 1.34

Lung fibroblasts from patients with emphysema show a reduced proliferation rate in culture. Eur Respir J (2004) 1.32

Codistribution of NOS and caveolin throughout peripheral vasculature and skeletal muscle of hamsters. Am J Physiol (1999) 1.31

Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolae. Proc Natl Acad Sci U S A (1997) 1.31

Accumulation of short telomeres in human fibroblasts prior to replicative senescence. Exp Cell Res (2000) 1.30

Replicative senescence and oxidant-induced premature senescence. Beyond the control of cell cycle checkpoints. Ann N Y Acad Sci (2000) 1.29

Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis. Arthritis Rheum (2006) 1.28

Cellular senescence in endothelial cells from atherosclerotic patients is accelerated by oxidative stress associated with cardiovascular risk factors. Mech Ageing Dev (2007) 1.28

Caveolae and caveolin-3 in muscular dystrophy. Trends Mol Med (2001) 1.27

Role of NF-kappaB-dependent caveolin-1 expression in the mechanism of increased endothelial permeability induced by lipopolysaccharide. J Biol Chem (2007) 1.25

Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS One (2010) 1.23

Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements. Cancer Res (2006) 1.73

Caveolae compartmentalization of heme oxygenase-1 in endothelial cells. FASEB J (2004) 1.54

Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts. Mol Biol Cell (2002) 1.45

Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel Mdm2/p53-mediated pathway. Cancer Res (2009) 1.36

Impairment of caveolae formation and T-system disorganization in human muscular dystrophy with caveolin-3 deficiency. Am J Pathol (2002) 1.24

Modulation of myoblast fusion by caveolin-3 in dystrophic skeletal muscle cells: implications for Duchenne muscular dystrophy and limb-girdle muscular dystrophy-1C. Mol Biol Cell (2003) 1.13

Caveolin-1 and caveolin-3 form heterooligomeric complexes in atrial cardiac myocytes that are required for doxorubicin-induced apoptosis. Am J Physiol Heart Circ Physiol (2007) 1.12

Nongenomic glucocorticoid receptor action regulates gap junction intercellular communication and neural progenitor cell proliferation. Proc Natl Acad Sci U S A (2011) 1.08

Transgenic overexpression of caveolin-3 in the heart induces a cardiomyopathic phenotype. Hum Mol Genet (2003) 1.08

The modulation of caveolin-1 expression controls satellite cell activation during muscle repair. FASEB J (2004) 1.07

Caveolin-1 expression is required for the development of pulmonary emphysema through activation of the ATM-p53-p21 pathway. J Biol Chem (2008) 1.06

Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells. FASEB J (2006) 1.06

Optimal plasma progranulin cutoff value for predicting null progranulin mutations in neurodegenerative diseases: a multicenter Italian study. Neurodegener Dis (2011) 1.05

Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence. EMBO Rep (2009) 1.02

Caveolin-1, cellular senescence and pulmonary emphysema. Aging (Albany NY) (2009) 1.00

Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence. Mol Biol Cell (2013) 0.96

Ligand-selective dissociation of activation and internalization of the parathyroid hormone (PTH) receptor: conditional efficacy of PTH peptide fragments. Endocrinology (2004) 0.95

Polymerase I and transcript release factor (PTRF)/cavin-1 is a novel regulator of stress-induced premature senescence. J Biol Chem (2011) 0.92

Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment. Cell Cycle (2013) 0.87

Interaction of caveolin-1 with Ku70 inhibits Bax-mediated apoptosis. PLoS One (2012) 0.87

Hypertrophy and atrophy inversely regulate Caveolin-3 expression in myoblasts. Biochem Biophys Res Commun (2007) 0.86

Caveolin-1 regulates genomic action of the glucocorticoid receptor in neural stem cells. Mol Cell Biol (2014) 0.84

Caveolin-3 promotes nicotinic acetylcholine receptor clustering and regulates neuromuscular junction activity. Mol Biol Cell (2009) 0.84

Mapping of oxidative stress response elements of the caveolin-1 promoter. Methods Mol Biol (2010) 0.81

The cytosolic sialidase Neu2 is degraded by autophagy during myoblast atrophy. Biochim Biophys Acta (2009) 0.81

Differentiation of human rhabdomyosarcoma RD cells is regulated by reciprocal, functional interactions between myostatin, p38 and extracellular regulated kinase signalling pathways. Eur J Cancer (2011) 0.79

Phenotypic behavior of C2C12 myoblasts upon expression of the dystrophy-related caveolin-3 P104L and TFT mutants. FEBS Lett (2007) 0.78

A window into the heterogeneity of human cerebrospinal fluid Aβ peptides. J Biomed Biotechnol (2011) 0.77

The enzymatic activity of sialidase Neu2 is inversely regulated during in vitro myoblast hypertrophy and atrophy. Biochem Biophys Res Commun (2008) 0.76

L6E9 myoblasts are deficient of myostatin and additional TGF-beta members are candidates to developmentally control their fiber formation. J Biomed Biotechnol (2010) 0.75