Published in Neuron on December 17, 2014
Altered Neuronal and Circuit Excitability in Fragile X Syndrome. Neuron (2015) 1.03
Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and Back. Neurotherapeutics (2015) 0.90
Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromes. Front Cell Neurosci (2015) 0.84
GABAB receptor-mediated feed-forward circuit dysfunction in the mouse model of fragile X syndrome. J Physiol (2015) 0.80
Effects of Chronic Sleep Restriction during Early Adolescence on the Adult Pattern of Connectivity of Mouse Secondary Motor Cortex. eNeuro (2016) 0.78
mGluR5 Positive and Negative Allosteric Modulators Differentially Affect Dendritic Spine Density and Morphology in the Prefrontal Cortex. CNS Neurol Disord Drug Targets (2015) 0.77
Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses. Elife (2016) 0.77
Unbiased, High-Throughput Electron Microscopy Analysis of Experience-Dependent Synaptic Changes in the Neocortex. J Neurosci (2015) 0.76
Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish. PLoS Genet (2015) 0.76
Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell (1991) 17.00
Neuronal circuits of the neocortex. Annu Rev Neurosci (2004) 7.70
Absence of expression of the FMR-1 gene in fragile X syndrome. Cell (1991) 7.04
Correction of fragile X syndrome in mice. Neuron (2007) 6.51
Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc Natl Acad Sci U S A (2002) 6.45
Morphological changes in dendritic spines associated with long-term synaptic plasticity. Annu Rev Neurosci (2001) 6.36
Array tomography: a new tool for imaging the molecular architecture and ultrastructure of neural circuits. Neuron (2007) 6.30
Structure and function of dendritic spines. Annu Rev Physiol (2002) 6.17
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression. Science (2000) 5.28
mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci (2009) 5.04
The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Neuron (2001) 4.97
Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits. Proc Natl Acad Sci U S A (1997) 4.73
Molecular mechanisms of dendritic spine morphogenesis. Curr Opin Neurobiol (2005) 4.31
Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice. Neuron (2012) 4.31
Mutations causing syndromic autism define an axis of synaptic pathophysiology. Nature (2011) 4.13
The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J Neurochem (2001) 3.81
Dysregulation of mTOR signaling in fragile X syndrome. J Neurosci (2010) 3.73
Characterization of the proteome, diseases and evolution of the human postsynaptic density. Nat Neurosci (2010) 3.67
Synapsin I (Protein I), a nerve terminal-specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes. J Cell Biol (1983) 3.49
Potentiation of cortical inhibition by visual deprivation. Nature (2006) 3.16
Single-synapse analysis of a diverse synapse population: proteomic imaging methods and markers. Neuron (2010) 2.86
Dendritic spines and long-term plasticity. Nat Rev Neurosci (2005) 2.83
A pilot open label, single dose trial of fenobam in adults with fragile X syndrome. J Med Genet (2009) 2.76
The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons. J Neurosci (2001) 2.68
Abnormal development of dendritic spines in FMR1 knock-out mice. J Neurosci (2001) 2.64
Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice. Neurobiol Dis (2008) 2.52
Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: a randomized, controlled, phase 2 trial. Sci Transl Med (2012) 2.51
Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome. J Neurophysiol (2008) 2.46
Extracellular-signal-regulated kinase signalling in neurons. Curr Opin Neurobiol (1999) 2.29
The pathophysiology of fragile X (and what it teaches us about synapses). Annu Rev Neurosci (2012) 2.16
Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex. Mol Cell Biol (1999) 2.13
Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome. J Physiol (2008) 2.08
Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1. J Neurosci (2004) 2.06
Organization of the core structure of the postsynaptic density. Proc Natl Acad Sci U S A (2008) 2.06
Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome. Neuron (2013) 2.00
PSD-95 is associated with the postsynaptic density and not with the presynaptic membrane at forebrain synapses. J Neurosci (1996) 1.95
Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments. PLoS Med (2013) 1.92
Sequence of abnormal dendritic spine development in primary somatosensory cortex of a mouse model of the fragile X mental retardation syndrome. Am J Med Genet A (2005) 1.90
Complementary distribution of vesicular glutamate transporters in the central nervous system. Neurosci Res (2002) 1.79
Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity. Proc Natl Acad Sci U S A (2003) 1.79
Deep cortical layers are activated directly by thalamus. Science (2013) 1.71
Excitatory signal flow and connectivity in a cortical column: focus on barrel cortex. Brain Struct Funct (2007) 1.70
Delayed stabilization of dendritic spines in fragile X mice. J Neurosci (2010) 1.69
Sub-diffraction limit localization of proteins in volumetric space using Bayesian restoration of fluorescence images from ultrathin specimens. PLoS Comput Biol (2012) 1.67
Synaptopathies: diseases of the synaptome. Curr Opin Neurobiol (2012) 1.62
GABA system dysfunction in autism and related disorders: from synapse to symptoms. Neurosci Biobehav Rev (2012) 1.61
The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuits. J Neurosci (2009) 1.60
Homeostatic scaling requires group I mGluR activation mediated by Homer1a. Neuron (2010) 1.59
Synapses and Alzheimer's disease. Cold Spring Harb Perspect Biol (2012) 1.57
Decreased GABA(A) receptor expression in the seizure-prone fragile X mouse. Neurosci Lett (2004) 1.55
Long-range connectivity of mouse primary somatosensory barrel cortex. Eur J Neurosci (2010) 1.54
A phenotypic and molecular characterization of the fmr1-tm1Cgr fragile X mouse. Genes Brain Behav (2004) 1.52
Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis. Hum Mol Genet (1997) 1.49
Mechanism-based approaches to treating fragile X. Pharmacol Ther (2010) 1.49
The evolution of the brain, the human nature of cortical circuits, and intellectual creativity. Front Neuroanat (2011) 1.48
Mapping functional connectivity in barrel-related columns reveals layer- and cell type-specific microcircuits. Brain Struct Funct (2007) 1.46
Vesicular glutamate transporters define two sets of glutamatergic afferents to the somatosensory thalamus and two thalamocortical projections in the mouse. J Comp Neurol (2008) 1.42
Deep molecular diversity of mammalian synapses: why it matters and how to measure it. Nat Rev Neurosci (2012) 1.40
Exaggerated behavioral phenotypes in Fmr1/Fxr2 double knockout mice reveal a functional genetic interaction between Fragile X-related proteins. Hum Mol Genet (2006) 1.38
Metabotropic glutamate receptor-dependent long-term potentiation. Neuropharmacology (2009) 1.37
Expression of the GABAergic system in animal models for fragile X syndrome and fragile X associated tremor/ataxia syndrome (FXTAS). Brain Res (2008) 1.35
Differential distribution of endoplasmic reticulum controls metabotropic signaling and plasticity at hippocampal synapses. Proc Natl Acad Sci U S A (2009) 1.33
Postnatal changes of vesicular glutamate transporter (VGluT)1 and VGluT2 immunoreactivities and their colocalization in the mouse forebrain. J Comp Neurol (2005) 1.32
VGluT2 immunochemistry identifies thalamocortical terminals in layer 4 of adult and developing visual cortex. J Comp Neurol (2005) 1.32
Intercellular (mis)communication in neurodegenerative disease. Neuron (2012) 1.31
Evolution of synapse complexity and diversity. Annu Rev Neurosci (2012) 1.27
Region-specific alterations in brain development in one- to three-year-old boys with fragile X syndrome. Proc Natl Acad Sci U S A (2010) 1.27
Somatosensory cortical barrel dendritic abnormalities in a mouse model of the fragile X mental retardation syndrome. Brain Res (2003) 1.26
Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome. J Neurosci (2010) 1.24
Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models. J Neurophysiol (2009) 1.24
Synaptic efficacy and reliability of excitatory connections between the principal neurones of the input (layer 4) and output layer (layer 5) of the neocortex. J Physiol (2000) 1.21
An anatomical substrate for experience-dependent plasticity of the rat barrel field cortex. Proc Natl Acad Sci U S A (1995) 1.19
Synaptopodin regulates plasticity of dendritic spines in hippocampal neurons. J Neurosci (2009) 1.17
Actin-associated protein synaptopodin in the rat hippocampal formation: localization in the spine neck and close association with the spine apparatus of principal neurons. J Comp Neurol (2000) 1.16
Early developmental alterations in GABAergic protein expression in fragile X knockout mice. Neuropharmacology (2010) 1.16
Developmental trajectories and correlates of sensory processing in young boys with fragile X syndrome. Phys Occup Ther Pediatr (2008) 1.15
Differential impact of the FMR1 gene on visual processing in fragile X syndrome. Brain (2004) 1.13
mGluR5 regulates glutamate-dependent development of the mouse somatosensory cortex. J Neurosci (2008) 1.12
Systematic mapping of fragile X granules in the mouse brain reveals a potential role for presynaptic FMRP in sensorimotor functions. J Comp Neurol (2012) 1.05
Object recognition impairment in Fmr1 knockout mice is reversed by amphetamine: involvement of dopamine in the medial prefrontal cortex. Behav Pharmacol (2004) 1.05
Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome. Hum Mol Genet (2012) 1.04
Contributions of ERK signaling in the striatum to instrumental learning and performance. Behav Brain Res (2010) 1.03
Oligomerization properties of fragile-X mental-retardation protein (FMRP) and the fragile-X-related proteins FXR1P and FXR2P. Biochem J (1999) 1.01
Extracellular signal-regulated kinase, synaptic plasticity, and memory. Rev Neurosci (2001) 0.98
The spine apparatus, synaptopodin, and dendritic spine plasticity. Neuroscientist (2010) 0.95
The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments in Fmr1 KO mice. Genes Brain Behav (2012) 0.95
Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2. PLoS One (2010) 0.94
Short- and long-term depression at glutamatergic synapses on hippocampal interneurons by group I mGluR activation. Neuropharmacology (2010) 0.91
Dendritic mRNA targeting and translation. Adv Exp Med Biol (2012) 0.89
Stimulated emission depletion (STED) microscopy reveals nanoscale defects in the developmental trajectory of dendritic spine morphogenesis in a mouse model of fragile X syndrome. J Neurosci (2014) 0.86
Long-term sensory deprivation selectively rearranges functional inhibitory circuits in mouse barrel cortex. Proc Natl Acad Sci U S A (2009) 0.85
Glutamate induces the elongation of early dendritic protrusions via mGluRs in wild type mice, but not in fragile X mice. PLoS One (2012) 0.84
Alzheimer's disease drug development: translational neuroscience strategies. CNS Spectr (2013) 0.84
Environmental enrichment reveals effects of genotype on hippocampal spine morphologies in the mouse model of Fragile X Syndrome. Cereb Cortex (2013) 0.84
Homer 1a suppresses neocortex long-term depression in a cortical layer-specific manner. J Neurophysiol (2007) 0.79
Synaptic plasticity in the adult visual cortex is regulated by the metabotropic glutamate receptor, mGluR5. Exp Brain Res (2009) 0.78