Published in Am J Physiol Renal Physiol on December 23, 2014
Suppressing angiotensinogen synthesis attenuates kidney cyst formation in a Pkd1 mouse model. FASEB J (2015) 0.86
Structure and functions of angiotensinogen. Hypertens Res (2016) 0.75
Proteomic analysis of AQP11-null kidney: Proximal tubular type polycystic kidney disease. Biochem Biophys Rep (2017) 0.75
Renin Angiotensin Aldosterone Inhibition in the Treatment of Cardiovascular Disease. Pharmacol Res (2017) 0.75
Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science (1993) 19.80
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci U S A (1993) 6.33
Polycystic kidney disease. N Engl J Med (2004) 5.73
Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis. Neuron (2012) 4.48
Somatic inactivation of Pkd2 results in polycystic kidney disease. Cell (1998) 3.84
Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease. Nat Med (2004) 3.09
PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell (2002) 3.09
Interleukin-12: biological properties and clinical application. Clin Cancer Res (2007) 3.00
The renin-angiotensin-aldosterone system and autosomal dominant polycystic kidney disease. N Engl J Med (1990) 2.82
Neutrophil-independent mechanisms of caspase-1- and IL-18-mediated ischemic acute tubular necrosis in mice. J Clin Invest (2002) 2.65
Morphometric and visual evaluation of fibrosis in renal biopsies. J Am Soc Nephrol (2010) 2.32
Cellular and molecular mechanisms in kidney fibrosis. J Clin Invest (2014) 2.07
Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney. J Pharmacol Exp Ther (2007) 1.88
Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney diseases. Nephrol Dial Transplant (2005) 1.76
Why kidneys fail in autosomal dominant polycystic kidney disease. Nat Rev Nephrol (2011) 1.65
The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. Inflamm Allergy Drug Targets (2009) 1.64
C-myc as an inducer of polycystic kidney disease in transgenic mice. Kidney Int (1991) 1.63
The HALT polycystic kidney disease trials: design and implementation. Clin J Am Soc Nephrol (2010) 1.59
A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease. J Am Soc Nephrol (2013) 1.49
Renal volume, renin-angiotensin-aldosterone system, hypertension, and left ventricular hypertrophy in patients with autosomal dominant polycystic kidney disease. J Am Soc Nephrol (2009) 1.39
A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease. Nat Med (2008) 1.38
Targeting of the rasT24 oncogene to the proximal convoluted tubules in transgenic mice results in hyperplasia and polycystic kidneys. Am J Pathol (1993) 1.34
Macrophages promote cyst growth in polycystic kidney disease. J Am Soc Nephrol (2011) 1.34
Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes. J Clin Invest (1997) 1.29
Gender and the effect of gonadal hormones on the progression of inherited polycystic kidney disease in rats. Am J Kidney Dis (1997) 1.22
1992 Homer Smith Award. Fluid secretion, cellular proliferation, and the pathogenesis of renal epithelial cysts. J Am Soc Nephrol (1993) 1.22
The intrarenal renin-angiotensin system in autosomal dominant polycystic kidney disease. Am J Physiol Renal Physiol (2004) 1.20
Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD. Am J Physiol Renal Physiol (2003) 1.18
Synthesis of renin by tubulocystic epithelium in autosomal-dominant polycystic kidney disease. Kidney Int (1992) 1.18
Polycystin-1 regulates STAT activity by a dual mechanism. Proc Natl Acad Sci U S A (2011) 1.15
Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease. J Pathol (2010) 1.12
VEGF receptor inhibition blocks liver cyst growth in pkd2(WS25/-) mice. Am J Physiol Cell Physiol (2007) 1.10
What is the role of tubular epithelial cell apoptosis in polycystic kidney disease (PKD)? Cell Cycle (2005) 1.10
Effect of statin and angiotensin-converting enzyme inhibition on structural and hemodynamic alterations in autosomal dominant polycystic kidney disease model. Am J Physiol Renal Physiol (2007) 1.09
Novel targets of antifibrotic and anti-inflammatory treatment in CKD. Nat Rev Nephrol (2014) 1.07
Evidence of angiogenesis and microvascular regression in autosomal-dominant polycystic kidney disease kidneys: a corrosion cast study. Kidney Int (2006) 1.05
Intracardiac and intrarenal renin-angiotensin systems: mechanisms of cardiovascular and renal effects. J Investig Med (2007) 1.04
Advanced oxidation protein products activate intrarenal renin-angiotensin system via a CD36-mediated, redox-dependent pathway. Antioxid Redox Signal (2012) 1.01
Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats. BMC Cardiovasc Disord (2002) 1.00
A novel inhibitor of tumor necrosis factor-alpha converting enzyme ameliorates polycystic kidney disease. Kidney Int (2001) 0.96
Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruption. J Am Soc Nephrol (2013) 0.96
CXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation. Am J Physiol Cell Physiol (2008) 0.94
Effect of sodium chloride, enalapril, and losartan on the development of polycystic kidney disease in Han:SPRD rats. Am J Kidney Dis (1994) 0.94
Classical Renin-Angiotensin system in kidney physiology. Compr Physiol (2014) 0.92
Regulation of STATs by polycystin-1 and their role in polycystic kidney disease. JAKSTAT (2013) 0.91
Molecular and Pathophysiological Features of Angiotensinogen: A Mini Review. N Am J Med Sci (Boston) (2011) 0.88
Rosiglitazone inhibits transforming growth factor-β1 mediated fibrogenesis in ADPKD cyst-lining epithelial cells. PLoS One (2011) 0.86
How does angiotensin II cause renal injury? Hypertension (2004) 0.85
Polycystic kidney disease: a case of suppressed autophagy? Semin Nephrol (2013) 0.85
Distinct patterns of kidney and liver cyst growth in pkd2(WS25/-) mice. Nephrol Dial Transplant (2010) 0.84
Transforming growth factor-β inhibits cystogenesis in human autosomal dominant polycystic kidney epithelial cells. Exp Cell Res (2012) 0.81
Progression of renal failure in the Han: SPRD polycystic kidney rat. Nephrol Dial Transplant (1994) 0.79
An mTOR anti-sense oligonucleotide decreases polycystic kidney disease in mice with a targeted mutation in Pkd2. Hum Mol Genet (2014) 0.79
Polycystic kidney disease: TGF-β signalling and vascular complications in ADPKD. Nat Rev Nephrol (2013) 0.78
Intravenous injection with antisense oligodeoxynucleotides against angiotensinogen decreases blood pressure in spontaneously hypertensive rats. Hypertension (1998) 0.78
Cilazapril delays progression of hypertension and uremia in rat polycystic kidney disease. Am J Kidney Dis (1995) 0.77