Published in J Clin Invest on March 15, 1997
Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest (2000) 6.84
Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc Natl Acad Sci U S A (1998) 2.17
Transgenic expression of proximal tubule peroxisome proliferator-activated receptor-alpha in mice confers protection during acute kidney injury. Kidney Int (2009) 1.91
Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension (2009) 1.68
Collecting duct-specific knockout of renin attenuates angiotensin II-induced hypertension. Am J Physiol Renal Physiol (2014) 1.58
Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis. Am J Pathol (2006) 1.35
Creation and characterization of a renin knockout rat. Hypertension (2011) 1.09
An androgen-inducible proximal tubule-specific Cre recombinase transgenic model. Am J Physiol Renal Physiol (2008) 0.92
Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice. Hypertension (2010) 0.89
Molecular and Pathophysiological Features of Angiotensinogen: A Mini Review. N Am J Med Sci (Boston) (2011) 0.88
A possible interaction between systemic and renal angiotensinogen in the control of blood pressure. Am J Hypertens (2013) 0.86
Androgen-induced hypertension in angiotensinogen deficient mice: role of 20-HETE and EETS. Prostaglandins Other Lipid Mediat (2014) 0.84
Divergent mechanism regulating fluid intake and metabolism by the brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol (2011) 0.84
Telemetric analysis of haemodynamic regulation during voluntary exercise training in mouse models. Exp Physiol (2011) 0.81
Antisense-mediated angiotensinogen inhibition slows polycystic kidney disease in mice with a targeted mutation in Pkd2. Am J Physiol Renal Physiol (2014) 0.77
Structure and functions of angiotensinogen. Hypertens Res (2016) 0.75
Neurohormonal Blockade in Heart Failure. Card Fail Rev (2017) 0.75
Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell (1987) 15.79
Some statistical methods useful in circulation research. Circ Res (1980) 11.88
Molecular basis of human hypertension: role of angiotensinogen. Cell (1992) 6.07
Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell (1994) 5.29
A molecular variant of angiotensinogen associated with preeclampsia. Nat Genet (1993) 3.78
Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci U S A (1995) 3.54
Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci U S A (1995) 3.46
A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature (1992) 3.40
Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature (1995) 3.23
Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature (1995) 3.06
Single-copy transgenic mice with chosen-site integration. Proc Natl Acad Sci U S A (1996) 2.84
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature (1995) 2.51
Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest (1996) 2.47
Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice. Proc Natl Acad Sci U S A (1994) 2.19
Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia. J Biol Chem (1995) 2.11
Angiotensinogen-deficient mice with hypotension. J Biol Chem (1994) 2.11
Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest (1995) 1.72
Angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad Sci U S A (1996) 1.61
Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. J Clin Invest (1996) 1.59
Expression of a foreign gene in a line of transgenic mice is modulated by a chromosomal position effect. Mol Cell Biol (1990) 1.41
Functional expression of the human angiotensinogen gene in transgenic mice. J Biol Chem (1994) 1.22
Chromosomal position effects and the modulation of transgene expression. Reprod Fertil Dev (1994) 1.19
A mutation of angiotensinogen in a patient with preeclampsia leads to altered kinetics of the renin-angiotensin system. J Biol Chem (1995) 1.19
Renin-angiotensin system in neonatal rats: induction of a renal abnormality in response to ACE inhibition or angiotensin II antagonism. Kidney Int (1994) 1.11
Angiotensin II type 1 receptor: role in renal growth and gene expression during normal development. Am J Physiol (1994) 1.08
Comparative studies on species-specific reactivity between renin and angiotensinogen. Mol Cell Biochem (1994) 1.07
Angiotensin II regulates insulin-like growth factor I gene expression in vascular smooth muscle cells. J Biol Chem (1993) 1.05
Antisense inhibition of AT1 receptor mRNA and angiotensinogen mRNA in the brain of spontaneously hypertensive rats reduces hypertension of neurogenic origin. Regul Pept (1993) 1.04
Regulated tissue- and cell-specific expression of the human renin gene in transgenic mice. Circ Res (1992) 0.99
Evidence for heritability of non-modulating essential hypertension. Hypertension (1989) 0.95
Analysis of the role of angiotensinogen in spontaneous hypertension. Hypertension (1995) 0.94
Angiotensin II stimulates the release of phospholipid-derived second messengers through multiple receptor subtypes in heart cells. J Biol Chem (1994) 0.91
Regulation of human renin mRNA expression and protein release in transgenic mice. Hypertension (1996) 0.83
Expression of the human renin gene in transgenic mice throughout ontogeny. Pediatr Nephrol (1993) 0.83
Plasma and renal prorenin/renin, renin mRNA, and blood pressure in Dahl salt-sensitive and salt-resistant rats. Hypertension (1996) 0.83
Antisense inhibition of hypertension in the spontaneously hypertensive rat. Hypertension (1995) 0.82
Renin-angiotensin system: kidney growth and development. Exp Nephrol (1994) 0.80
Phenotypic inhibition of the renin-angiotensin system, emergence of the Ren-2 gene, and adaptive radiation of mice. Gen Comp Endocrinol (1991) 0.79
Angiotensin II induces TGF-beta 1 production in rat heart endothelial cells. Biochim Biophys Acta (1994) 0.78
Myocardial hypertrophy, angiotensin, and ACE inhibitors. Angiology (1993) 0.77
Pathophysiology of vascular smooth muscle in renin promoter-T-antigen transgenic mice. Am J Physiol (1991) 0.77
A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res (1984) 181.98
The structure and evolution of the human beta-globin gene family. Cell (1980) 21.24
Charon phages: safer derivatives of bacteriophage lambda for DNA cloning. Science (1977) 20.27
Base substitutions, length differences and DNA strand asymmetries in the human G gamma and A gamma fetal globin gene region. Cell (1981) 16.76
Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes. Cell (1980) 14.88
A receptor kinase-like protein encoded by the rice disease resistance gene, Xa21. Science (1995) 9.79
Cloning human fetal gamma globin and mouse alpha-type globin DNA: preparation and screening of shotgun collections. Science (1978) 8.24
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. Science (1990) 8.17
Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. Nature (1985) 7.95
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci U S A (1993) 7.13
Targetted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature (1988) 6.12
Quantitative procedures for use with the Edman-Begg sequenator. Partial sequences of two unusual immunoglobulin light chains, Rzf and Sac. Biochemistry (1971) 6.10
Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (1996) 5.94
Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci U S A (1998) 5.86
An animal model for cystic fibrosis made by gene targeting. Science (1992) 5.75
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc Natl Acad Sci U S A (1997) 5.54
Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function. J Am Coll Cardiol (1997) 5.33
Recombinant fragment assay for gene targetting based on the polymerase chain reaction. Nucleic Acids Res (1988) 4.84
Requirement of MIP-1 alpha for an inflammatory response to viral infection. Science (1995) 4.55
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell (1995) 4.47
Hybridization of labeled RNA to DNA in agarose gels. Nucleic Acids Res (1975) 4.38
Tomato Prf is a member of the leucine-rich repeat class of plant disease resistance genes and lies embedded within the Pto kinase gene cluster. Cell (1996) 4.29
Altering genes in animals by gene targeting. Annu Rev Immunol (1992) 4.22
A history of the human fetal globin gene duplication. Cell (1981) 4.19
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell (1995) 4.17
Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA. Proc Natl Acad Sci U S A (1984) 4.16
A noninvasive computerized tail-cuff system for measuring blood pressure in mice. Hypertension (1995) 4.08
TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell (1993) 4.02
Antibacterial agents based on the cyclic D,L-alpha-peptide architecture. Nature (2001) 4.00
Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes of Escherichia coli. Nucleic Acids Res (1984) 3.94
Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest (1998) 3.71
Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension. Science (1995) 3.61
Antibiotic resistance mutations in ribosomal RNA genes of Escherichia coli. Methods Enzymol (1988) 3.60
Unexpected relationships between four large deletions in the human beta-globin gene cluster. Cell (1983) 3.57
Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci U S A (1995) 3.54
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc Natl Acad Sci U S A (1995) 3.53
Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci U S A (1995) 3.46
Evolution of sensory complexity recorded in a myxobacterial genome. Proc Natl Acad Sci U S A (2006) 3.35
Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature (1995) 3.23
Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene. Mol Endocrinol (1995) 3.21
Targeted mutation of the Hprt gene in mouse embryonic stem cells. Proc Natl Acad Sci U S A (1988) 3.20
Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc Natl Acad Sci U S A (1989) 3.07
Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nat Med (2001) 3.07
Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel. J Biol Chem (1992) 3.03
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc Natl Acad Sci U S A (1997) 2.99
A mouse alpha-globin-related pseudogene lacking intervening sequences. Nature (1980) 2.92
Single-copy transgenic mice with chosen-site integration. Proc Natl Acad Sci U S A (1996) 2.84
Different clinical features of aortic intramural hematoma versus dissection involving the ascending aorta. J Am Coll Cardiol (2001) 2.77
Identifying specific causes of kidney allograft loss. Am J Transplant (2008) 2.77
Initiation of protein synthesis at an unusual position in an immunoglobulin gene? Science (1972) 2.74
Mechanism of action of the antimicrobial peptide buforin II: buforin II kills microorganisms by penetrating the cell membrane and inhibiting cellular functions. Biochem Biophys Res Commun (1998) 2.67
Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci U S A (1989) 2.59
Reproductive and neonatal losses associated with possible encephalomyocarditis virus infection in pigs. Vet Rec (1990) 2.52
Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products. Mol Cell Biol (1992) 2.51
The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system. Proc Natl Acad Sci U S A (1999) 2.48
Idiopathic transverse myelitis: MR characteristics. AJNR Am J Neuroradiol (1996) 2.48
PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction. Kidney Int (2001) 2.41
Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses. Science (1998) 2.38
Antibody responses in bursa-deficient chickens. J Immunol (1966) 2.37
Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proc Natl Acad Sci U S A (1992) 2.37
Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis. Science (1992) 2.36
A coagulation factor IX-deficient mouse model for human hemophilia B. Blood (1997) 2.36
Double-strand gap repair in a mammalian gene targeting reaction. Mol Cell Biol (1991) 2.28
Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res (2000) 2.28
Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2. J Clin Invest (2000) 2.27
Cloning human fetal gamma globin and mouse alpha-type globin DNA: characterization and partial sequencing. Science (1978) 2.25
Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells. Mol Cell Biol (1991) 2.25
The evolution of multigene families: human haptoglobin genes. Annu Rev Genet (1986) 2.21
Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice. Proc Natl Acad Sci U S A (1994) 2.19
Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc Natl Acad Sci U S A (1998) 2.17
Bleeding Dieulafoy's lesions and the choice of endoscopic method: comparing the hemostatic efficacy of mechanical and injection methods. Gastrointest Endosc (2000) 2.16
Recombination and balanced chromosome polymorphism suggested by DNA sequences 5' to the human delta-globin gene. Proc Natl Acad Sci U S A (1983) 2.11
An indirect fluorescent antibody test for the detection of antibody to swine infertility and respiratory syndrome virus in swine sera. J Vet Diagn Invest (1992) 2.09
Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel. Nature (1991) 2.09
Duplication within the haptoglobin Hp2 gene. Nature (1984) 2.08
The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo. Nat Med (1999) 2.06
Prognostic factors and recurrence pattern in node-negative advanced gastric cancer. Eur J Surg Oncol (2012) 2.05
Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells. Proc Natl Acad Sci U S A (1991) 2.04
Induction of calcium currents by the expression of the alpha 1-subunit of the dihydropyridine receptor from skeletal muscle. Nature (1989) 2.04
Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. J Clin Invest (2001) 2.03
Nucleotide sequence of 16-kilobase pairs of DNA 5' to the human epsilon-globin gene. J Biol Chem (1985) 2.02
A mouse model for beta 0-thalassemia. Proc Natl Acad Sci U S A (1995) 2.01
Efficient transformation and frequent single-site, single-copy insertion of DNA can be obtained in mouse erythroleukemia cells transformed by electroporation. Exp Hematol (1986) 1.98
PhyloDraw: a phylogenetic tree drawing system. Bioinformatics (2000) 1.96
Electromyographic activity over facial muscle regions can differentiate the valence and intensity of affective reactions. J Pers Soc Psychol (1986) 1.95
Gene conversions and their relation to homologous chromosome pairing. Philos Trans R Soc Lond B Biol Sci (1986) 1.95
Accurate modification of a chromosomal plasmid by homologous recombination in human cells. Proc Natl Acad Sci U S A (1987) 1.93
Differential expression of angiotensin receptor 1A and 1B in mouse. Am J Physiol (1994) 1.91
RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney. Kidney Int (2006) 1.88
The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux disease: a nationwide multicentre prospective study in Korea. Aliment Pharmacol Ther (2007) 1.85
Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene. Proc Natl Acad Sci U S A (2001) 1.85
Cotransformation and gene targeting in mouse embryonic stem cells. Mol Cell Biol (1991) 1.84