Distinct p21 requirements for regulating normal and self-reactive T cells through IFN-γ production.

PubWeight™: 0.77‹?›

🔗 View Article (PMC 4287747)

Published in Sci Rep on January 09, 2015

Authors

Lidia Daszkiewicz1, Cristina Vázquez-Mateo1, Gorjana Rackov1, André Ballesteros-Tato1, Kathrin Weber1, Adrián Madrigal-Avilés1, Mauro Di Pilato2, Arun Fotedar3, Rati Fotedar4, Juana M Flores5, Mariano Esteban2, Carlos Martínez-A1, Dimitrios Balomenos1

Author Affiliations

1: Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, UAM Campus de Cantoblanco, E-28049 Madrid, Spain.
2: Department of Cellular and Molecular Biology, Centro Nacional de Biotecnología/CSIC, UAM Campus de Cantoblanco, E-28049 Madrid, Spain.
3: Cancer Cell Biology Program, Sidney Kimmel Cancer Center, San Diego, CA, USA.
4: Sanford-Burnham Medical Research Institute, San Diego, CA, USA.
5: Animal Biology Department, School of Veterinary Medicine, Universidad Complutense, Madrid, Spain.

Articles cited by this

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell (1993) 33.20

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell (1995) 12.39

Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (1995) 8.53

IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB. Immunity (1997) 3.60

The enemy within: keeping self-reactive T cells at bay in the periphery. Nat Rev Immunol (2002) 3.47

Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines. J Exp Med (2004) 3.43

Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2. J Exp Med (1981) 3.27

Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J Clin Invest (1998) 2.60

Qualitative changes accompany memory T cell generation: faster, more effective responses at lower doses of antigen. J Immunol (2000) 2.23

An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome. Ann Intern Med (1999) 2.20

Roles of interferon-gamma and interleukin-4 in murine lupus. J Clin Invest (1997) 2.04

Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway. Ann Rheum Dis (2011) 1.91

Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1). Cancer Cell (2005) 1.78

The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity. Arthritis Res (2001) 1.74

CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21. J Clin Invest (2011) 1.71

Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice. PLoS Biol (2004) 1.68

Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. Genes Immun (2008) 1.59

Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice. J Immunol (2010) 1.54

Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Immunity (2002) 1.53

Human TCR-alpha beta+ CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype. J Immunol (2009) 1.52

The interferon signature in autoimmune diseases. Curr Opin Rheumatol (2013) 1.46

How signaling and gene transcription aberrations dictate the systemic lupus erythematosus T cell phenotype. Trends Immunol (2008) 1.44

The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development. Nat Med (2000) 1.43

Apoptosis, Fas and systemic autoimmunity: the MRL-lpr/lpr model. Curr Opin Immunol (1994) 1.40

The potential of CD4 T-cell memory. Immunology (2010) 1.40

Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease. J Exp Med (2008) 1.38

The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalance. J Immunol (1998) 1.29

The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells. Immunity (2012) 1.20

Interleukin-17-producing T cells in lupus. Curr Opin Rheumatol (2010) 1.19

p21CIP1/WAF1 controls proliferation of activated/memory T cells and affects homeostasis and memory T cell responses. J Immunol (2007) 1.13

Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity. J Exp Med (2004) 1.13

Polar opposites: Erk direction of CD4 T cell subsets. J Immunol (2012) 1.06

Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc Natl Acad Sci U S A (2010) 1.05

The CDK domain of p21 is a suppressor of IL-1beta-mediated inflammation in activated macrophages. Eur J Immunol (2009) 1.04

Mice thrive without Cdk4 and Cdk2. Mol Oncol (2007) 1.02

The proliferative in vivo activities of lpr double-negative T cells and the primary role of p59fyn in their activation and expansion. J Immunol (1997) 0.99

Autocrine production of IFN-gamma by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr mice. J Immunol (2002) 0.98

Effect of p21waf1/cip1 transgene on radiation induced apoptosis in T cells. Oncogene (1999) 0.98

IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells. J Immunol (2014) 0.98

The death receptor Fas (CD95/APO-1) mediates the deletion of T lymphocytes undergoing homeostatic proliferation. J Immunol (2005) 0.97

Cell-cycle regulation in immunity, tolerance and autoimmunity. Immunol Today (2000) 0.93

Cyclin-dependent kinase inhibitor p21, via its C-terminal domain, is essential for resolution of murine inflammatory arthritis. Arthritis Rheum (2012) 0.92

Regulation of macrophage activation and septic shock susceptibility via p21(WAF1/CIP1). Eur J Immunol (2009) 0.90

cAMP-responsive element modulator α (CREMα) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease. J Biol Chem (2013) 0.89

Development of lupus in BXSB mice is independent of IL-4. J Immunol (2000) 0.88

Advances in autoimmune lymphoproliferative syndromes. Eur J Haematol (2011) 0.87

p21(waf1/CIP1), a CDK inhibitor and a negative feedback system that controls macrophage activation. Eur J Immunol (2009) 0.85

B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency. J Exp Med (2008) 0.84

Cell cycle regulation by FasL and Apo2L/TRAIL in human T-cell blasts. Implications for autoimmune lymphoproliferative syndromes. J Leukoc Biol (2008) 0.81

p21(Cip1) up-regulated during histone deacetylase inhibitor-induced CD4(+) T-cell anergy selectively associates with mitogen-activated protein kinases. Immunology (2009) 0.81

CD69 guides CD4+ T cells to the seat of memory. Proc Natl Acad Sci U S A (2012) 0.81

Abnormal activation of the Akt-GSK3beta signaling pathway in peripheral blood T cells from patients with systemic lupus erythematosus. Cell Cycle (2009) 0.81

New vaccinia virus promoter as a potential candidate for future vaccines. J Gen Virol (2013) 0.80

The role of IL12 in helper T-cell differentiation. Res Immunol (1996) 0.76