Published in Cell Death Dis on January 15, 2015
Thiamine Deficiency and Neurodegeneration: the Interplay Among Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy. Mol Neurobiol (2016) 0.75
PKR deficiency alters E. coli-induced sickness behaviors but does not exacerbate neuroimmune responses or bacterial load. J Neuroinflammation (2015) 0.75
Suppression of adiponectin receptor 1 promotes memory dysfunction and Alzheimer's disease-like pathologies. Sci Rep (2017) 0.75
PKR involvement in Alzheimer's disease. Alzheimers Res Ther (2017) 0.75
A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94
Gene-specific regulation by general translation factors. Cell (2002) 6.05
Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res (2000) 4.82
Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action. Microbiol Mol Biol Rev (2006) 4.13
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell (2010) 4.01
A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Proc Natl Acad Sci U S A (1997) 3.88
The dsRNA protein kinase PKR: virus and cell control. Biochimie (2007) 3.67
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature (2012) 3.67
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron (2008) 2.99
eIF2 and the control of cell physiology. Semin Cell Dev Biol (2004) 2.67
The quantiative measurement of motor inco-ordination in naive mice using an acelerating rotarod. J Pharm Pharmacol (1968) 2.28
Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity. Mol Cell (2012) 2.14
The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin. EMBO J (2000) 1.98
Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition. Cell (2011) 1.89
Oxidative stress increases expression and activity of BACE in NT2 neurons. Neurobiol Dis (2002) 1.85
TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys. Cell Metab (2013) 1.74
PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR. J Biol Chem (2000) 1.72
Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease. Neuroreport (2002) 1.55
eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation. J Neurosci (2010) 1.34
Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region. EMBO Rep (2004) 1.27
Oxidative stress is associated with region-specific neuronal death during thiamine deficiency. J Neuropathol Exp Neurol (1999) 1.25
Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiol Aging (2008) 1.24
Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease. Diabetes (2014) 1.16
Neuronal loss in functional zones of the cerebellum of chronic alcoholics with and without Wernicke's encephalopathy. Neuroscience (1999) 1.14
Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degeneration. J Neurochem (2002) 1.11
Reversal of thiamine deficiency-induced neurodegeneration. J Neuropathol Exp Neurol (2003) 1.10
Interaction between RAX and PKR modulates the effect of ethanol on protein synthesis and survival of neurons. J Biol Chem (2006) 1.09
Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease. Neurochem Int (2005) 1.06
Translational regulation of BACE-1 expression in neuronal and non-neuronal cells. Nucleic Acids Res (2004) 1.05
Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway. Biochim Biophys Acta (2012) 1.05
Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism. Neurochem Int (2004) 1.05
Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region. Nucleic Acids Res (2007) 1.03
Activation of double-stranded RNA-activated protein kinase by mild impairment of oxidative metabolism in neurons. J Neurochem (2007) 1.01
Oxidative stress induces PKR-dependent apoptosis via IFN-gamma activation signaling in Jurkat T cells. Biochem Biophys Res Commun (2008) 1.00
Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Neurobiol Dis (2007) 0.99
Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease. Neuroscience (2006) 0.98
Thiamine deficiency increases β-secretase activity and accumulation of β-amyloid peptides. Neurobiol Aging (2009) 0.95
Pyrithiamine as a substrate for thiamine pyrophosphokinase. J Biol Chem (2005) 0.94
Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death. Cell Death Differ (2010) 0.93
Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease. Brain Pathol (2010) 0.92
Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism. J Neuropathol Exp Neurol (2000) 0.91
CD40-CD40L interactions promote neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism. Neurochem Int (2005) 0.90
Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression. PLoS One (2011) 0.90
Alterations of thiamine phosphorylation and of thiamine-dependent enzymes in Alzheimer's disease. Metab Brain Dis (1996) 0.89
Increased cerebrospinal fluid levels of double-stranded RNA-dependant protein kinase in Alzheimer's disease. Biol Psychiatry (2012) 0.88
Neuronal phosphorylated RNA-dependent protein kinase in Creutzfeldt-Jakob disease. J Neuropathol Exp Neurol (2009) 0.86
Exposure to pyrithiamine increases β-amyloid accumulation, Tau hyperphosphorylation, and glycogen synthase kinase-3 activity in the brain. Neurotox Res (2010) 0.85
Autophagy alleviates neurodegeneration caused by mild impairment of oxidative metabolism. J Neurochem (2013) 0.84
Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability. Neurochem Int (2007) 0.83
Cerebrospinal fluid PKR level predicts cognitive decline in Alzheimer's disease. PLoS One (2013) 0.83
The PKR activator PACT is induced by Aβ: involvement in Alzheimer's disease. Brain Pathol (2011) 0.81
Organization and morphology of thalamocortical neurons of mouse ventral lateral thalamus. Somatosens Mot Res (2010) 0.81
Thiamine deficiency caused by thiamine antagonists triggers upregulation of apoptosis inducing factor gene expression and leads to caspase 3-mediated apoptosis in neuronally differentiated rat PC-12 cells. Acta Biochim Pol (2007) 0.81
Proteostasis impairment: at the intersection between Alzheimer's disease and diabetes. Cell Metab (2013) 0.80
Nitro-oxidative stress after neuronal ischemia induces protein nitrotyrosination and cell death. Oxid Med Cell Longev (2013) 0.80
Automatic counting and positioning of 5-bromo-2-deoxyuridine (BrdU) positive cells in cortical layers of rat brain slices. Neurotoxicology (2014) 0.80