Published in J Neurosci on February 17, 2010
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. J Neurosci (2012) 2.35
Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci (2013) 2.35
Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition. Cell (2011) 1.89
Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife (2013) 1.85
Systemic inflammation and delirium: important co-factors in the progression of dementia. Biochem Soc Trans (2011) 1.36
Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. Cell Rep (2012) 1.24
Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation. Proc Natl Acad Sci U S A (2011) 1.22
Translational control in synaptic plasticity and cognitive dysfunction. Annu Rev Neurosci (2014) 1.21
Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α. Nat Neurosci (2014) 1.08
Translational control mechanisms in long-lasting synaptic plasticity and memory. J Biol Chem (2010) 1.02
PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease. Neurobiol Aging (2014) 1.00
Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596. PLoS One (2010) 0.98
Acute D-serine treatment produces antidepressant-like effects in rodents. Int J Neuropsychopharmacol (2011) 0.90
Deletion of the eIF2α Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease. PLoS One (2013) 0.89
Review: Modulating the unfolded protein response to prevent neurodegeneration and enhance memory. Neuropathol Appl Neurobiol (2015) 0.88
Molecular mechanisms underlying formation of long-term reward memories and extinction memories in the honeybee (Apis mellifera). Learn Mem (2014) 0.87
Mechanisms of translational regulation in synaptic plasticity. Curr Opin Neurobiol (2010) 0.87
Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory. Neurobiol Learn Mem (2013) 0.86
The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression. Learn Mem (2014) 0.86
Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulation. Mol Brain (2011) 0.83
Ceftriaxone, a GLT-1 transporter activator, disrupts hippocampal learning in rats. Pharmacol Biochem Behav (2014) 0.82
Less translational control, more memory. Elife (2013) 0.81
Roles of eIF2α kinases in the pathogenesis of Alzheimer's disease. Front Mol Neurosci (2014) 0.81
Activating transcription factor 4 (ATF4) modulates post-synaptic development and dendritic spine morphology. Front Cell Neurosci (2014) 0.81
Unparalleled control of neural activity using orthogonal pharmacogenetics. ACS Chem Neurosci (2012) 0.80
PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model. Cell Death Dis (2015) 0.78
Trib3 is developmentally and nutritionally regulated in the brain but is dispensable for spatial memory, fear conditioning and sensing of amino acid-imbalanced diet. PLoS One (2014) 0.76
The Extracellular-Regulated Kinase Effector Lk6 is Required for Glutamate Receptor Localization at the Drosophila Neuromuscular Junction. J Exp Neurosci (2016) 0.75
Amphetamine elevates phosphorylation of eukaryotic initiation factor 2α (eIF2α) in the rat forebrain via activating dopamine D1 and D2 receptors. Brain Res (2016) 0.75
PKR involvement in Alzheimer's disease. Alzheimers Res Ther (2017) 0.75
Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury. Proc Natl Acad Sci U S A (2017) 0.75
Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell (2000) 17.44
Translational regulation of GCN4 and the general amino acid control of yeast. Annu Rev Microbiol (2005) 11.48
Subregion- and cell type-restricted gene knockout in mouse brain. Cell (1996) 8.02
Function and regulation of CREB family transcription factors in the nervous system. Neuron (2002) 7.99
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem (1999) 7.94
A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes. Histochemistry (1993) 7.78
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci U S A (2004) 7.03
Gene-specific regulation by general translation factors. Cell (2002) 6.05
The many faces of CREB. Trends Neurosci (2005) 5.58
Protein synthesis and memory: a review. Psychol Bull (1984) 5.26
Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron (1998) 5.05
Translational control of long-lasting synaptic plasticity and memory. Neuron (2009) 4.77
CREB and memory. Annu Rev Neurosci (1998) 4.76
Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron (2008) 3.97
Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc Natl Acad Sci U S A (1998) 3.88
Translational regulatory mechanisms in persistent forms of synaptic plasticity. Neuron (2004) 3.64
eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell (2007) 3.46
A multigene family encoding a diverse array of putative pheromone receptors in mammals. Cell (1997) 3.31
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron (2008) 2.99
Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast. Proc Natl Acad Sci U S A (1993) 2.90
Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampus-dependent spatial memory. Neuron (2002) 2.87
Identification of a signaling pathway involved in calcium regulation of BDNF expression. Neuron (1998) 2.82
Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change. Cell (1995) 2.75
Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature (2005) 2.67
Eukaryotic translation initiation factors and regulators. Curr Opin Struct Biol (2003) 2.63
Translational control of localized mRNAs: restricting protein synthesis in space and time. Nat Rev Mol Cell Biol (2008) 2.50
Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science (2006) 2.49
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia. Cell (1994) 2.42
Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization. Learn Mem (1999) 2.41
Postadolescent changes in regional cerebral protein synthesis: an in vivo study in the FMR1 null mouse. J Neurosci (2005) 2.40
NMDA receptor-mediated control of protein synthesis at developing synapses. Nat Neurosci (2000) 2.37
Structure and function of the protein kinase R. Curr Top Microbiol Immunol (2007) 2.34
Rapid and reversible chemical inactivation of synaptic transmission in genetically targeted neurons. Neuron (2005) 2.26
Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter. Mol Cell Biol (1989) 2.20
Spatial organization of direct hippocampal field CA1 axonal projections to the rest of the cerebral cortex. Brain Res Rev (2007) 2.20
BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci U S A (2008) 2.16
Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics. J Biol Chem (2002) 2.08
Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation. J Neurosci (2005) 2.00
Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element. Proc Natl Acad Sci U S A (1992) 1.97
Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches. Hippocampus (2002) 1.91
Age-dependent requirement of AKAP150-anchored PKA and GluR2-lacking AMPA receptors in LTP. EMBO J (2007) 1.88
Positive and negative regulatory mechanisms that mediate long-term memory storage. Brain Res Brain Res Rev (1998) 1.68
Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity. Proc Natl Acad Sci U S A (2007) 1.30
The influence of duration of protein synthesis inhibition on memory. Physiol Behav (1973) 1.29
The dsRNA-dependent protein kinase, PKR and cell death. Cell Death Differ (2005) 1.29
Granulocyte-macrophage colony-stimulating factor and interleukin-3 signaling pathways converge on the CREB-binding site in the human egr-1 promoter. Mol Cell Biol (1994) 1.14
CA3 NMDA receptors are crucial for rapid and automatic representation of context memory. Eur J Neurosci (2006) 1.12
An inbred 129SvEv GFPCre transgenic mouse that deletes loxP-flanked genes in all tissues. Nucleic Acids Res (2003) 0.96
Down-regulation of Bcl-2 and Bcl-xL expression with bispecific antisense treatment in glioblastoma cell lines induce cell death. J Neurochem (2003) 0.95
Recovery as a function of the degree of amnesia due to protein synthesis inhibition. Pharmacol Biochem Behav (1978) 0.94
Chemically inducible inactivation of protein synthesis in genetically targeted neurons. J Neurosci (2009) 0.86
Phosphorylation of translation initiation factor eIF2alpha in the brain during pilocarpine-induced status epilepticus in mice. Neurosci Lett (2004) 0.80
Importance of spatial location in active avoidance tasks. J Comp Physiol Psychol (1968) 0.78
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell (2003) 12.50
The state of US health, 1990-2010: burden of diseases, injuries, and risk factors. JAMA (2013) 10.43
SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A (2003) 6.80
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N Engl J Med (2014) 6.50
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature (2011) 6.08
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell (2007) 4.76
Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science (2004) 4.74
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes. Nat Neurosci (2009) 4.32
Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet (2016) 4.29
Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning. Neuron (2010) 4.14
National, regional, and global trends in adult overweight and obesity prevalences. Popul Health Metr (2012) 4.13
Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J Neurosci (2002) 4.01
New insights into BDNF function in depression and anxiety. Nat Neurosci (2007) 3.94
Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci U S A (2009) 3.89
NMDA receptor-dependent ocular dominance plasticity in adult visual cortex. Neuron (2003) 3.79
Distinct role of long 3' UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons. Cell (2008) 3.63
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat Neurosci (2005) 3.17
Krüppel-like factor 4 regulates macrophage polarization. J Clin Invest (2011) 3.08
BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol Learn Mem (2007) 2.96
Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis. Lancet Neurol (2012) 2.75
Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron (2005) 2.68
MRSA epidemic linked to a quickly spreading colonization and virulence determinant. Nat Med (2012) 2.61
Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature (2012) 2.59
Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons. Nat Neurosci (2005) 2.59
Lipid rafts mediate chemotropic guidance of nerve growth cones. Neuron (2004) 2.46
New insights in the biology of BDNF synthesis and release: implications in CNS function. J Neurosci (2009) 2.40
Postadolescent changes in regional cerebral protein synthesis: an in vivo study in the FMR1 null mouse. J Neurosci (2005) 2.40
Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron (2003) 2.37
A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. Nat Med (2009) 2.37
Neuronal release of proBDNF. Nat Neurosci (2009) 2.36
Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J Clin Invest (2010) 2.32
The global cardiovascular risk transition: associations of four metabolic risk factors with national income, urbanization, and Western diet in 1980 and 2008. Circulation (2013) 2.31
Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice. Gastroenterology (2012) 2.01
Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. J Neurosci (2010) 1.99
Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1. Neuron (2002) 1.96
Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology (2007) 1.91
Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis. Blood (2011) 1.86
A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development. PLoS Genet (2012) 1.72
Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase e. Neuron (2005) 1.69
Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons. Nat Neurosci (2010) 1.68
Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF. Ageing Res Rev (2004) 1.66
Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications. Trends Neurosci (2005) 1.65
Control of extracellular cleavage of ProBDNF by high frequency neuronal activity. Proc Natl Acad Sci U S A (2009) 1.64
Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. Neuron (2011) 1.57
GABAergic interneuron origin of schizophrenia pathophysiology. Neuropharmacology (2011) 1.55
Quantitative assessment of AKAP12 promoter methylation in colorectal cancer using methylation-sensitive high resolution melting: Correlation with Duke's stage. Cancer Biol Ther (2010) 1.50
Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia. Cell (2012) 1.48
Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice. J Clin Invest (2012) 1.46
Outbreak of infection caused by Enterobacter cloacae producing the novel VEB-3 beta-lactamase in China. J Clin Microbiol (2005) 1.46
Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex. Proc Natl Acad Sci U S A (2009) 1.46
Distinct 3'UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF). Proc Natl Acad Sci U S A (2010) 1.46
Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts. J Neurosci (2003) 1.45
Neurologic, gastric, and opthalmologic pathologies in a murine model of mucolipidosis type IV. Am J Hum Genet (2007) 1.44
Detection of extended-spectrum beta-lactamases in clinical isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother (2006) 1.38
BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts: roles in synaptic modulation. J Cell Biol (2004) 1.35
Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Sci Transl Med (2010) 1.35
Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity. Neuropharmacology (2002) 1.34
MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma. Acta Neuropathol (2011) 1.33
Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse. J Neurosci (2006) 1.32
Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome. Int J Neuropsychopharmacol (2010) 1.31
Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expression. Proc Natl Acad Sci U S A (2009) 1.31
Role of dysbindin in dopamine receptor trafficking and cortical GABA function. Proc Natl Acad Sci U S A (2009) 1.26
Human hepatocyte growth factor receptor is a cellular coreceptor for adeno-associated virus serotype 3. Hum Gene Ther (2010) 1.26
Neuropathology of the Mcoln1(-/-) knockout mouse model of mucolipidosis type IV. J Neuropathol Exp Neurol (2009) 1.26
Fibroblast growth factor receptor-1 is required for long-term potentiation, memory consolidation, and neurogenesis. Biol Psychiatry (2007) 1.25
The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts. J Mol Cell Cardiol (2008) 1.25
Increased rates of cerebral glucose metabolism in a mouse model of fragile X mental retardation. Proc Natl Acad Sci U S A (2002) 1.25
Molecular characterization of Staphylococcus epidermidis strains isolated from a teaching hospital in Shanghai, China. J Med Microbiol (2009) 1.24
Genetic neuroscience of mammalian learning and memory. Philos Trans R Soc Lond B Biol Sci (2003) 1.23
Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival. Mol Brain (2009) 1.22
Dissociation of social and nonsocial anxiety in a mouse model of fragile X syndrome. Neurosci Lett (2009) 1.22
Mutations in AKAP5 disrupt dendritic signaling complexes and lead to electrophysiological and behavioral phenotypes in mice. PLoS One (2010) 1.21
Quantitative study of salivary secretion in Parkinson's disease. Mov Disord (2006) 1.20
BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission. J Neurosci (2012) 1.20
Altered synapse formation in the adult somatosensory cortex of brain-derived neurotrophic factor heterozygote mice. J Neurosci (2004) 1.20
Krüppel-like factor 4 regulates pressure-induced cardiac hypertrophy. J Mol Cell Cardiol (2010) 1.19
CD45-positive blood cells give rise to uterine epithelial cells in mice. Stem Cells (2007) 1.17
NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis. Learn Mem (2006) 1.16
Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx. J Cell Biol (2003) 1.16
Hilar mossy cell degeneration causes transient dentate granule cell hyperexcitability and impaired pattern separation. Neuron (2012) 1.14
Klf15 orchestrates circadian nitrogen homeostasis. Cell Metab (2012) 1.14
Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression. Drug Metab Dispos (2004) 1.14
CA3 NMDA receptors are crucial for rapid and automatic representation of context memory. Eur J Neurosci (2006) 1.12
Regulation of cortical interneurons by neurotrophins: from development to cognitive disorders. Neuroscientist (2006) 1.12
Implication of geranylgeranyltransferase I in synapse formation. Neuron (2003) 1.11
TrkB as a potential synaptic and behavioral tag. J Neurosci (2011) 1.11
Ca2+ influx-independent synaptic potentiation mediated by mitochondrial Na(+)-Ca2+ exchanger and protein kinase C. J Cell Biol (2003) 1.11
GluN2B in corticostriatal circuits governs choice learning and choice shifting. Nat Neurosci (2013) 1.10
Multiple tumor types may originate from bone marrow-derived cells. Neoplasia (2006) 1.10