Vaccine-induced Human Antibodies Specific for the Third Variable Region of HIV-1 gp120 Impose Immune Pressure on Infecting Viruses.

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Published in EBioMedicine on November 01, 2014

Authors

Susan Zolla-Pazner1, Paul T Edlefsen2, Morgane Rolland3, Xiang-Peng Kong4, Allan deCamp2, Raphael Gottardo2, Constance Williams4, Sodsai Tovanabutra3, Sandra Sharpe-Cohen4, James I Mullins5, Mark S deSouza6, Nicos Karasavvas7, Sorachai Nitayaphan7, Supachai Rerks-Ngarm8, Punnee Pitisuttihum9, Jaranit Kaewkungwal9, Robert J O'Connell7, Merlin L Robb10, Nelson L Michael10, Jerome H Kim10, Peter Gilbert2

Author Affiliations

1: New York Veterans Affairs Harbor Healthcare System, 423 East 23 Street, New York, NY 10010, USA ; New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
2: Vaccine and Infectious Disease Division, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M2-C200, Seattle, WA 98109, USA.
3: Department of Retrovirology, Walter Reed Army Institute of Research, Building 503, Silver Spring, MD 20910, USA.
4: New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
5: Department of Microbiology, University of Washington, 358B Rosen Building, Campus box 358070, Seattle, WA 98195.
6: Thai Red Cross AIDS Research Center 104, Tower 2, Rajdumari Rd. Pathumwan, Bangkok, Thailand, 10330.
7: Armed Forces Research Institute of Medical Science (AFRIMS) Department of Retrovirology Humoral Immunology and Assessment Laboratory, 315/6 Rajvithi Rd. Bangkok, 10400, Thailand.
8: Department of Disease Control, Ministry of Public Health, Nonthaburi, 11000, Thailand.
9: Department of Clinical Tropical Medicine, Mahidol University, 420/6 Ratchawithi Road, Ratchathewi, Bangkok 10400, Thailand.
10: U.S. Army Military HIV Research Program, 6720A Rockledge Dr., Suite 400, Bethesda MD, 20817.

Associated clinical trials:

HIV Vaccine Trial in Thai Adults | NCT00223080

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