The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation.

PubWeight™: 0.77‹?›

🔗 View Article (PMC 4309453)

Published in PLoS One on January 28, 2015

Authors

Jin Hu1, Ting Lin2, Yuehong Gao3, Junyue Xu2, Chao Jiang2, Guanghui Wang2, Guojun Bu3, Huaxi Xu1, Haifeng Chen2, Yun-wu Zhang3

Author Affiliations

1: Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China; Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China.
2: Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
3: Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China.

Articles cited by this

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (2002) 49.51

Alzheimer's disease: the amyloid cascade hypothesis. Science (1992) 13.80

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science (1999) 13.19

Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov (2006) 11.77

Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature (1999) 5.77

Control of peripheral nerve myelination by the beta-secretase BACE1. Science (2006) 4.55

Isolation of microtubule protein from cultured mouse neuroblastoma cells. Proc Natl Acad Sci U S A (1970) 4.20

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol (2013) 4.16

Bace1 modulates myelination in the central and peripheral nervous system. Nat Neurosci (2006) 3.85

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci U S A (1999) 3.85

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J Biol Chem (1998) 3.83

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nat Med (2003) 3.78

Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci (1999) 3.77

Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res (1978) 3.51

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J Neurosci (2005) 3.23

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci U S A (2000) 2.96

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients. Proc Natl Acad Sci U S A (2004) 2.88

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice. J Biol Chem (2007) 2.22

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus. J Biol Chem (1996) 2.19

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. J Biol Chem (2005) 2.15

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem (2005) 2.03

APP processing in Alzheimer's disease. Mol Brain (2011) 2.02

Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener (2011) 1.58

Proteolytic processing of Alzheimer's β-amyloid precursor protein. J Neurochem (2011) 1.50

Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease. J Neurosci (2008) 1.39

Therapeutic potential of resveratrol in Alzheimer's disease. BMC Neurosci (2008) 1.19

Natural products as a source of Alzheimer's drug leads. Nat Prod Rep (2010) 1.13

Expression and activity of beta-site amyloid precursor protein cleaving enzyme in Alzheimer's disease. Biochem Soc Trans (2005) 1.02

Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations. J Neurosci Methods (2011) 1.00

Natural polyphenols against neurodegenerative disorders: potentials and pitfalls. Ageing Res Rev (2012) 0.98

γ-secretase-dependent cleavage initiates notch signaling from the plasma membrane. Traffic (2010) 0.95

Resveratrol oligomers isolated from Carex species inhibit growth of human colon tumorigenic cells mediated by cell cycle arrest. J Agric Food Chem (2011) 0.92

A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation. Neuron (2009) 0.91

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology. Mol Neurodegener (2012) 0.89

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing. Mol Neurodegener (2012) 0.88

Stilbene derivatives as human 5-HT(6) receptor antagonists from the root of Caragana sinica. Biol Pharm Bull (2010) 0.84

Anti-inflammatory effects of resveratrol and oligostilbenes from Vitis thunbergii var. taiwaniana against lipopolysaccharide-induced arthritis. J Agric Food Chem (2011) 0.83

Naturally occurring protein kinase C inhibitors; II. Isolation of oligomeric stilbenes from Caragana sinica. Planta Med (1995) 0.82

Neuroprotective activity of Vitis thunbergii var. taiwaniana extracts in vitro and in vivo. J Med Food (2010) 0.81

Evaluation of antitumor effects of two vine stalk oligomers of resveratrol on a panel of lymphoid and myeloid cell lines: comparison with resveratrol. Life Sci (2007) 0.81

Assessment of estrogenic activity of natural compounds using improved E-screen assay. Acta Pharmacol Sin (2002) 0.80

Antioxidative oligostilbenes from Caragana sinica. Bioorg Med Chem Lett (2011) 0.80

Bioactive stilbenes from Vitis vinifera grapevine shoots extracts. J Sci Food Agric (2013) 0.79

Ferritin light chain interacts with PEN-2 and affects γ-secretase activity. Neurosci Lett (2013) 0.79

Comparative analyses of stilbenoids in canes of major Vitis vinifera L. cultivars. J Agric Food Chem (2013) 0.78

[Inhibition of protein kinase C by stilbenoids]. Yao Xue Xue Bao (1994) 0.78

Two new oligostilbenes from the stem of Parthenocissus quinquefolia. J Asian Nat Prod Res (2014) 0.77

Stilbene oligomers in roots of Sophora davidii. Phytochemistry (2000) 0.76

Oligomeric stilbenes from the root of Caragana stenophylla. Chem Pharm Bull (Tokyo) (2004) 0.76

Identification and ecdysteroid antagonist activity of three oligostilbenes from the seeds of Carex pendula (Cyperaceae). Phytochemistry (2001) 0.76

Identification and determination of oligomeric stilbenes in the roots of Caragana species by capillary electrophoresis. Planta Med (2001) 0.76

[The binding sites of estrogen receptor for miyabenol C and kobophenol A]. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) (2003) 0.76